Age‐related hypermethylation of the hMLH1 promoter in gastric cancers
To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestina...
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| Veröffentlicht in: | International journal of cancer 2001-10, Vol.94 (2), p.208-211 |
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| container_title | International journal of cancer |
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| creator | Nakajima, Tomoko Akiyama, Yoshimitsu Shiraishi, Junichi Arai, Tomio Yanagisawa, Yuka Ara, Miyuki Fukuda, Yoshiharu Sawabe, Motoji Saitoh, Kiyoshi Kamiyama, Ryuichi Hirokawa, Katsuiku Yuasa, Yasuhito |
| description | To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestinal metaplastic tissues adjacent to cancers with hypermethylation did not exhibit any hMLH1 methylation, indicating that it may be specific to gastric cancers. The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people. © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.1454 |
| format | Article |
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Normal and intestinal metaplastic tissues adjacent to cancers with hypermethylation did not exhibit any hMLH1 methylation, indicating that it may be specific to gastric cancers. The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people. © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.1454</identifier><identifier>PMID: 11668499</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adaptor Proteins, Signal Transducing ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; aging ; Biological and medical sciences ; Carrier Proteins ; DNA Methylation ; Female ; gastric cancer ; Gastroenterology. Liver. Pancreas. Abdomen ; hMLH1 ; Humans ; Male ; Medical sciences ; methylation ; Middle Aged ; MLHI gene ; MutL Protein Homolog 1 ; Neoplasm Proteins - genetics ; Nuclear Proteins ; Promoter Regions, Genetic ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>International journal of cancer, 2001-10, Vol.94 (2), p.208-211</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.1454$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.1454$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14129064$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11668499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakajima, Tomoko</creatorcontrib><creatorcontrib>Akiyama, Yoshimitsu</creatorcontrib><creatorcontrib>Shiraishi, Junichi</creatorcontrib><creatorcontrib>Arai, Tomio</creatorcontrib><creatorcontrib>Yanagisawa, Yuka</creatorcontrib><creatorcontrib>Ara, Miyuki</creatorcontrib><creatorcontrib>Fukuda, Yoshiharu</creatorcontrib><creatorcontrib>Sawabe, Motoji</creatorcontrib><creatorcontrib>Saitoh, Kiyoshi</creatorcontrib><creatorcontrib>Kamiyama, Ryuichi</creatorcontrib><creatorcontrib>Hirokawa, Katsuiku</creatorcontrib><creatorcontrib>Yuasa, Yasuhito</creatorcontrib><title>Age‐related hypermethylation of the hMLH1 promoter in gastric cancers</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestinal metaplastic tissues adjacent to cancers with hypermethylation did not exhibit any hMLH1 methylation, indicating that it may be specific to gastric cancers. The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people. © 2001 Wiley‐Liss, Inc.</description><subject>Adaptor Proteins, Signal Transducing</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aging</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>gastric cancer</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>hMLH1</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>methylation</subject><subject>Middle Aged</subject><subject>MLHI gene</subject><subject>MutL Protein Homolog 1</subject><subject>Neoplasm Proteins - genetics</subject><subject>Nuclear Proteins</subject><subject>Promoter Regions, Genetic</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1OwzAQhS0EoqUgcQKUDexSPLFjJ8uqgraoiA2sIyeZNK7yh50KZccROCMnwVWLunqaeZ9G8x4ht0CnQGnwqLfZFHjIz8gYaCx9GkB4TsbOor4EJkbkytotpQAh5ZdkBCBExON4TBazDf5-_xisVI-5Vw4dmhr7cnCzbhuvLby-RK98XS_B60xbtz0aTzfeRtne6MzLVJOhsdfkolCVxZujTsjH89P7fOmv3xar-Wztd4wK7jMlFeOZVFkBmMoIUMo8KIqYMok8L_KIKiUoYyyQoWBhymlYYCokl0K4JZuQh8Nd98vnDm2f1NpmWFWqwXZnE4gghlhKB94dwV1aY550RtfKDMl_dAfcHwFlM1UVxgXR9sRxCGL3suP8A_elKxxOPk321Seu-mRffbJ6me-V_QEX8nTH</recordid><startdate>20011015</startdate><enddate>20011015</enddate><creator>Nakajima, Tomoko</creator><creator>Akiyama, Yoshimitsu</creator><creator>Shiraishi, Junichi</creator><creator>Arai, Tomio</creator><creator>Yanagisawa, Yuka</creator><creator>Ara, Miyuki</creator><creator>Fukuda, Yoshiharu</creator><creator>Sawabe, Motoji</creator><creator>Saitoh, Kiyoshi</creator><creator>Kamiyama, Ryuichi</creator><creator>Hirokawa, Katsuiku</creator><creator>Yuasa, Yasuhito</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20011015</creationdate><title>Age‐related hypermethylation of the hMLH1 promoter in gastric cancers</title><author>Nakajima, Tomoko ; Akiyama, Yoshimitsu ; Shiraishi, Junichi ; Arai, Tomio ; Yanagisawa, Yuka ; Ara, Miyuki ; Fukuda, Yoshiharu ; Sawabe, Motoji ; Saitoh, Kiyoshi ; Kamiyama, Ryuichi ; Hirokawa, Katsuiku ; Yuasa, Yasuhito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3064-3a7a34c7acf1eb781e77d2ff9037e4dfd80aa60333275635b405feb6747663323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adaptor Proteins, Signal Transducing</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aging</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>gastric cancer</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>hMLH1</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>methylation</topic><topic>Middle Aged</topic><topic>MLHI gene</topic><topic>MutL Protein Homolog 1</topic><topic>Neoplasm Proteins - genetics</topic><topic>Nuclear Proteins</topic><topic>Promoter Regions, Genetic</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Normal and intestinal metaplastic tissues adjacent to cancers with hypermethylation did not exhibit any hMLH1 methylation, indicating that it may be specific to gastric cancers. The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people. © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11668499</pmid><doi>10.1002/ijc.1454</doi><tpages>4</tpages></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing Adult Age Factors Aged Aged, 80 and over aging Biological and medical sciences Carrier Proteins DNA Methylation Female gastric cancer Gastroenterology. Liver. Pancreas. Abdomen hMLH1 Humans Male Medical sciences methylation Middle Aged MLHI gene MutL Protein Homolog 1 Neoplasm Proteins - genetics Nuclear Proteins Promoter Regions, Genetic Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Age‐related hypermethylation of the hMLH1 promoter in gastric cancers |
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