Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India
Gastric cancer is one of the most common malignancies in India. DNA repair gene or xenobiotic pathway gene polymorphisms have recently been shown to affect individual susceptibility to gastric cancer. Here, the possible interaction between common polymorphisms in X-ray repair cross complementing gro...
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| Veröffentlicht in: | Tumor biology 2016-07, Vol.37 (7), p.9139-9149 |
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| creator | Ghosh, Soumee Ghosh, Sudakshina Bankura, Biswabandhu Saha, Makhan Lal Maji, Suvendu Ghatak, Souvik Pattanayak, Arup Kumar Sadhukhan, Susanta Guha, Manalee Nachimuthu, Senthil Kumar Panda, Chinmay Kumar Maity, Biswanath Das, Madhusudan |
| description | Gastric cancer is one of the most common malignancies in India. DNA repair gene or xenobiotic pathway gene polymorphisms have recently been shown to affect individual susceptibility to gastric cancer. Here, the possible interaction between common polymorphisms in X-ray repair cross complementing group I (
XRCC1
) gene and glutathione
S
-transferase (
GST
) genes (
GSTM1
,
GSTT1
and
GSTP1
), smoking and alcohol consumption and overall survival in gastric cancer patients were evaluated. In this population-based case control study, 70 gastric cancer patients and 82 healthy controls were enrolled. The epidemiological data were collected by a standard questionnaire, and blood samples were collected from each individual.
XRCC1
Arg194Trp, Arg280His and Arg399Gln polymorphisms were determined by polymerase chain reaction and direct DNA sequencing.
GSTM1
and
GSTT1
null polymorphisms and
GSTP1
Ile105Val polymorphism were identified by multiplex polymerase chain reaction and restriction fragment length polymorphism (RFLP), respectively. The risk of gastric cancer was significantly elevated in individuals with
XRCC1
Arg/Gln +Gln/Gln (
p =
0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07–5.06) and
GSTP1
Val/Val genotype (
p =
0.009; odds ratio = 8.64; 95 % CI 1.84–40.55). An elevated risk for GC was observed in smokers and alcohol consumers carrying
GSTP1
Ile/Val +Val/Val genotype (
p =
0.041; odds ratio = 3.71; 95 % CI 0.98–14.12;
p
= 0.002; odds ratio = 12.31; 95 % CI 1.71–88.59). These findings suggest that
XRCC1
rs25487 and
GSTP1
rs1695 can be considered as a risk factor associated with gastric cancer and might be used as a molecular marker for evaluating the susceptibility of the disease. |
| doi_str_mv | 10.1007/s13277-015-4780-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1819147196</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4151112451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-c8e937bca55098386482d0cdcb3fe61c907ced223ae6df72d7f215afd55ca0713</originalsourceid><addsrcrecordid>eNqNkctu1DAUhiMEoqXwAGyQJTYsCBzb8SXLablVqmADYmk5tjPjKrGD7ajMW_DIeDoFISQkVrZ8vvOfY31N8xTDKwwgXmdMiRAtYNZ2QkLL7jWnuCO0BSrhfr0DhrYjkp40j3K-hgr2PX_YnBAuuOQYnzY_NjlH43XxMaA4ojcfNyi5RfuEdLDouwtx8LF4gxZddjd6j7YuOLTEaT_HtOx8njO68WV3-37g8pqNW4of_OTLHpWItjqXVCtGB-PSIci7UDLyAX11uaBzF7Z6eokug_X6cfNg1FN2T-7Os-bLu7efLz60V5_eX15srlrTASutka6nYjCaMegllbyTxIKxZqCj49j0IIyzhFDtuB0FsWIkmOnRMmY0CEzPmhfH3CXFb2tdQ82-Lj5NOri4ZoUl7nEncM__ByVSCs66ij7_C72Oawr1I7cUBSaAVgofKZNizsmNakl-1mmvMKiDWXU0q6owdTCrWO15dpe8DrOzvzt-qawAOQK5lsLWpT9G_zP1J6X6r_M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1812305703</pqid></control><display><type>article</type><title>Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Ghosh, Soumee ; Ghosh, Sudakshina ; Bankura, Biswabandhu ; Saha, Makhan Lal ; Maji, Suvendu ; Ghatak, Souvik ; Pattanayak, Arup Kumar ; Sadhukhan, Susanta ; Guha, Manalee ; Nachimuthu, Senthil Kumar ; Panda, Chinmay Kumar ; Maity, Biswanath ; Das, Madhusudan</creator><creatorcontrib>Ghosh, Soumee ; Ghosh, Sudakshina ; Bankura, Biswabandhu ; Saha, Makhan Lal ; Maji, Suvendu ; Ghatak, Souvik ; Pattanayak, Arup Kumar ; Sadhukhan, Susanta ; Guha, Manalee ; Nachimuthu, Senthil Kumar ; Panda, Chinmay Kumar ; Maity, Biswanath ; Das, Madhusudan</creatorcontrib><description>Gastric cancer is one of the most common malignancies in India. DNA repair gene or xenobiotic pathway gene polymorphisms have recently been shown to affect individual susceptibility to gastric cancer. Here, the possible interaction between common polymorphisms in X-ray repair cross complementing group I (
XRCC1
) gene and glutathione
S
-transferase (
GST
) genes (
GSTM1
,
GSTT1
and
GSTP1
), smoking and alcohol consumption and overall survival in gastric cancer patients were evaluated. In this population-based case control study, 70 gastric cancer patients and 82 healthy controls were enrolled. The epidemiological data were collected by a standard questionnaire, and blood samples were collected from each individual.
XRCC1
Arg194Trp, Arg280His and Arg399Gln polymorphisms were determined by polymerase chain reaction and direct DNA sequencing.
GSTM1
and
GSTT1
null polymorphisms and
GSTP1
Ile105Val polymorphism were identified by multiplex polymerase chain reaction and restriction fragment length polymorphism (RFLP), respectively. The risk of gastric cancer was significantly elevated in individuals with
XRCC1
Arg/Gln +Gln/Gln (
p =
0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07–5.06) and
GSTP1
Val/Val genotype (
p =
0.009; odds ratio = 8.64; 95 % CI 1.84–40.55). An elevated risk for GC was observed in smokers and alcohol consumers carrying
GSTP1
Ile/Val +Val/Val genotype (
p =
0.041; odds ratio = 3.71; 95 % CI 0.98–14.12;
p
= 0.002; odds ratio = 12.31; 95 % CI 1.71–88.59). These findings suggest that
XRCC1
rs25487 and
GSTP1
rs1695 can be considered as a risk factor associated with gastric cancer and might be used as a molecular marker for evaluating the susceptibility of the disease.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-015-4780-5</identifier><identifier>PMID: 26768611</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Case-Control Studies ; DNA repair ; DNA Repair - genetics ; DNA-Binding Proteins - genetics ; Female ; Gastric cancer ; Genetic Predisposition to Disease - genetics ; Genotype ; Genotype & phenotype ; Glutathione S-Transferase pi - genetics ; Glutathione Transferase - genetics ; Humans ; India ; Male ; Middle Aged ; Original Article ; Polymorphism ; Polymorphism, Genetic - genetics ; Polymorphism, Restriction Fragment Length - genetics ; Population genetics ; Risk Factors ; Stomach Neoplasms - genetics ; X-ray Repair Cross Complementing Protein 1</subject><ispartof>Tumor biology, 2016-07, Vol.37 (7), p.9139-9149</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-c8e937bca55098386482d0cdcb3fe61c907ced223ae6df72d7f215afd55ca0713</citedby><cites>FETCH-LOGICAL-c405t-c8e937bca55098386482d0cdcb3fe61c907ced223ae6df72d7f215afd55ca0713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-015-4780-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-015-4780-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26768611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghosh, Soumee</creatorcontrib><creatorcontrib>Ghosh, Sudakshina</creatorcontrib><creatorcontrib>Bankura, Biswabandhu</creatorcontrib><creatorcontrib>Saha, Makhan Lal</creatorcontrib><creatorcontrib>Maji, Suvendu</creatorcontrib><creatorcontrib>Ghatak, Souvik</creatorcontrib><creatorcontrib>Pattanayak, Arup Kumar</creatorcontrib><creatorcontrib>Sadhukhan, Susanta</creatorcontrib><creatorcontrib>Guha, Manalee</creatorcontrib><creatorcontrib>Nachimuthu, Senthil Kumar</creatorcontrib><creatorcontrib>Panda, Chinmay Kumar</creatorcontrib><creatorcontrib>Maity, Biswanath</creatorcontrib><creatorcontrib>Das, Madhusudan</creatorcontrib><title>Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>Gastric cancer is one of the most common malignancies in India. DNA repair gene or xenobiotic pathway gene polymorphisms have recently been shown to affect individual susceptibility to gastric cancer. Here, the possible interaction between common polymorphisms in X-ray repair cross complementing group I (
XRCC1
) gene and glutathione
S
-transferase (
GST
) genes (
GSTM1
,
GSTT1
and
GSTP1
), smoking and alcohol consumption and overall survival in gastric cancer patients were evaluated. In this population-based case control study, 70 gastric cancer patients and 82 healthy controls were enrolled. The epidemiological data were collected by a standard questionnaire, and blood samples were collected from each individual.
XRCC1
Arg194Trp, Arg280His and Arg399Gln polymorphisms were determined by polymerase chain reaction and direct DNA sequencing.
GSTM1
and
GSTT1
null polymorphisms and
GSTP1
Ile105Val polymorphism were identified by multiplex polymerase chain reaction and restriction fragment length polymorphism (RFLP), respectively. The risk of gastric cancer was significantly elevated in individuals with
XRCC1
Arg/Gln +Gln/Gln (
p =
0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07–5.06) and
GSTP1
Val/Val genotype (
p =
0.009; odds ratio = 8.64; 95 % CI 1.84–40.55). An elevated risk for GC was observed in smokers and alcohol consumers carrying
GSTP1
Ile/Val +Val/Val genotype (
p =
0.041; odds ratio = 3.71; 95 % CI 0.98–14.12;
p
= 0.002; odds ratio = 12.31; 95 % CI 1.71–88.59). These findings suggest that
XRCC1
rs25487 and
GSTP1
rs1695 can be considered as a risk factor associated with gastric cancer and might be used as a molecular marker for evaluating the susceptibility of the disease.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>DNA repair</subject><subject>DNA Repair - genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Glutathione S-Transferase pi - genetics</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>India</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Polymorphism, Restriction Fragment Length - genetics</subject><subject>Population genetics</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - genetics</subject><subject>X-ray Repair Cross Complementing Protein 1</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhiMEoqXwAGyQJTYsCBzb8SXLablVqmADYmk5tjPjKrGD7ajMW_DIeDoFISQkVrZ8vvOfY31N8xTDKwwgXmdMiRAtYNZ2QkLL7jWnuCO0BSrhfr0DhrYjkp40j3K-hgr2PX_YnBAuuOQYnzY_NjlH43XxMaA4ojcfNyi5RfuEdLDouwtx8LF4gxZddjd6j7YuOLTEaT_HtOx8njO68WV3-37g8pqNW4of_OTLHpWItjqXVCtGB-PSIci7UDLyAX11uaBzF7Z6eokug_X6cfNg1FN2T-7Os-bLu7efLz60V5_eX15srlrTASutka6nYjCaMegllbyTxIKxZqCj49j0IIyzhFDtuB0FsWIkmOnRMmY0CEzPmhfH3CXFb2tdQ82-Lj5NOri4ZoUl7nEncM__ByVSCs66ij7_C72Oawr1I7cUBSaAVgofKZNizsmNakl-1mmvMKiDWXU0q6owdTCrWO15dpe8DrOzvzt-qawAOQK5lsLWpT9G_zP1J6X6r_M</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Ghosh, Soumee</creator><creator>Ghosh, Sudakshina</creator><creator>Bankura, Biswabandhu</creator><creator>Saha, Makhan Lal</creator><creator>Maji, Suvendu</creator><creator>Ghatak, Souvik</creator><creator>Pattanayak, Arup Kumar</creator><creator>Sadhukhan, Susanta</creator><creator>Guha, Manalee</creator><creator>Nachimuthu, Senthil Kumar</creator><creator>Panda, Chinmay Kumar</creator><creator>Maity, Biswanath</creator><creator>Das, Madhusudan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20160701</creationdate><title>Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India</title><author>Ghosh, Soumee ; Ghosh, Sudakshina ; Bankura, Biswabandhu ; Saha, Makhan Lal ; Maji, Suvendu ; Ghatak, Souvik ; Pattanayak, Arup Kumar ; Sadhukhan, Susanta ; Guha, Manalee ; Nachimuthu, Senthil Kumar ; Panda, Chinmay Kumar ; Maity, Biswanath ; Das, Madhusudan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-c8e937bca55098386482d0cdcb3fe61c907ced223ae6df72d7f215afd55ca0713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>DNA repair</topic><topic>DNA Repair - genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Glutathione S-Transferase pi - genetics</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>India</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Polymorphism, Restriction Fragment Length - genetics</topic><topic>Population genetics</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - genetics</topic><topic>X-ray Repair Cross Complementing Protein 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghosh, Soumee</creatorcontrib><creatorcontrib>Ghosh, Sudakshina</creatorcontrib><creatorcontrib>Bankura, Biswabandhu</creatorcontrib><creatorcontrib>Saha, Makhan Lal</creatorcontrib><creatorcontrib>Maji, Suvendu</creatorcontrib><creatorcontrib>Ghatak, Souvik</creatorcontrib><creatorcontrib>Pattanayak, Arup Kumar</creatorcontrib><creatorcontrib>Sadhukhan, Susanta</creatorcontrib><creatorcontrib>Guha, Manalee</creatorcontrib><creatorcontrib>Nachimuthu, Senthil Kumar</creatorcontrib><creatorcontrib>Panda, Chinmay Kumar</creatorcontrib><creatorcontrib>Maity, Biswanath</creatorcontrib><creatorcontrib>Das, Madhusudan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghosh, Soumee</au><au>Ghosh, Sudakshina</au><au>Bankura, Biswabandhu</au><au>Saha, Makhan Lal</au><au>Maji, Suvendu</au><au>Ghatak, Souvik</au><au>Pattanayak, Arup Kumar</au><au>Sadhukhan, Susanta</au><au>Guha, Manalee</au><au>Nachimuthu, Senthil Kumar</au><au>Panda, Chinmay Kumar</au><au>Maity, Biswanath</au><au>Das, Madhusudan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>37</volume><issue>7</issue><spage>9139</spage><epage>9149</epage><pages>9139-9149</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>Gastric cancer is one of the most common malignancies in India. DNA repair gene or xenobiotic pathway gene polymorphisms have recently been shown to affect individual susceptibility to gastric cancer. Here, the possible interaction between common polymorphisms in X-ray repair cross complementing group I (
XRCC1
) gene and glutathione
S
-transferase (
GST
) genes (
GSTM1
,
GSTT1
and
GSTP1
), smoking and alcohol consumption and overall survival in gastric cancer patients were evaluated. In this population-based case control study, 70 gastric cancer patients and 82 healthy controls were enrolled. The epidemiological data were collected by a standard questionnaire, and blood samples were collected from each individual.
XRCC1
Arg194Trp, Arg280His and Arg399Gln polymorphisms were determined by polymerase chain reaction and direct DNA sequencing.
GSTM1
and
GSTT1
null polymorphisms and
GSTP1
Ile105Val polymorphism were identified by multiplex polymerase chain reaction and restriction fragment length polymorphism (RFLP), respectively. The risk of gastric cancer was significantly elevated in individuals with
XRCC1
Arg/Gln +Gln/Gln (
p =
0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07–5.06) and
GSTP1
Val/Val genotype (
p =
0.009; odds ratio = 8.64; 95 % CI 1.84–40.55). An elevated risk for GC was observed in smokers and alcohol consumers carrying
GSTP1
Ile/Val +Val/Val genotype (
p =
0.041; odds ratio = 3.71; 95 % CI 0.98–14.12;
p
= 0.002; odds ratio = 12.31; 95 % CI 1.71–88.59). These findings suggest that
XRCC1
rs25487 and
GSTP1
rs1695 can be considered as a risk factor associated with gastric cancer and might be used as a molecular marker for evaluating the susceptibility of the disease.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26768611</pmid><doi>10.1007/s13277-015-4780-5</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1010-4283 |
| ispartof | Tumor biology, 2016-07, Vol.37 (7), p.9139-9149 |
| issn | 1010-4283 1423-0380 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1819147196 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Female Gastric cancer Genetic Predisposition to Disease - genetics Genotype Genotype & phenotype Glutathione S-Transferase pi - genetics Glutathione Transferase - genetics Humans India Male Middle Aged Original Article Polymorphism Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length - genetics Population genetics Risk Factors Stomach Neoplasms - genetics X-ray Repair Cross Complementing Protein 1 |
| title | Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India |
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