Sorption and toxicity reduction of pharmaceutically active compounds and endocrine disrupting chemicals in the presence of colloidal humic acid
This study investigated the toxicity changes and sorption of pharmaceuticals and endocrine disrupters in the presence of humic acid (HA). For the sorption experiment, a dead end filtration (DEF) system was used to separate bound and free-form target compounds. An algae growth inhibition test and E-s...
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| Veröffentlicht in: | Water science and technology 2016-08, Vol.74 (4), p.904-913 |
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| creator | Kim, Injeong Kim, Hyo-Dong Jeong, Tae-Yong Kim, Sang Don |
| description | This study investigated the toxicity changes and sorption of pharmaceuticals and endocrine disrupters in the presence of humic acid (HA). For the sorption experiment, a dead end filtration (DEF) system was used to separate bound and free-form target compounds. An algae growth inhibition test and E-screen assay were conducted to estimate the toxic effect of pharmaceutically active compounds (PhACs) and endocrine disrupting chemicals (EDCs), respectively. The permeate concentration was confirmed using liquid chromatography-mass spectrometry. In the sorption test, we observed significant sorption of PhACs and EDCs on colloidal HA, except for sulfamethoxazole (SMX). The values of log KCOC derived from DEF determinations ranged from 4.40 to 5.03. The removal efficiency varied with the HA concentration and the target chemical properties. Tetracycline and 4-octylphenol showed the highest sorption or removal efficiency (≈50%), even at 5 mg C/L HA. The algal growth inhibition of PhACs and the estrogenic effects of EDCs were significantly decreased in proportion to HA concentrations, except for SMX. In addition, the chemical analysis results showed a positive relationship with the bioassay results. Consequently, the sorption of PhACs and EDCs onto colloidal HA should be emphasized in natural environments because it significantly reduces bioavailable concentrations and toxicity to aquatic organisms. |
| doi_str_mv | 10.2166/wst.2016.270 |
| format | Article |
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For the sorption experiment, a dead end filtration (DEF) system was used to separate bound and free-form target compounds. An algae growth inhibition test and E-screen assay were conducted to estimate the toxic effect of pharmaceutically active compounds (PhACs) and endocrine disrupting chemicals (EDCs), respectively. The permeate concentration was confirmed using liquid chromatography-mass spectrometry. In the sorption test, we observed significant sorption of PhACs and EDCs on colloidal HA, except for sulfamethoxazole (SMX). The values of log KCOC derived from DEF determinations ranged from 4.40 to 5.03. The removal efficiency varied with the HA concentration and the target chemical properties. Tetracycline and 4-octylphenol showed the highest sorption or removal efficiency (≈50%), even at 5 mg C/L HA. The algal growth inhibition of PhACs and the estrogenic effects of EDCs were significantly decreased in proportion to HA concentrations, except for SMX. In addition, the chemical analysis results showed a positive relationship with the bioassay results. Consequently, the sorption of PhACs and EDCs onto colloidal HA should be emphasized in natural environments because it significantly reduces bioavailable concentrations and toxicity to aquatic organisms.</description><identifier>ISSN: 0273-1223</identifier><identifier>EISSN: 1996-9732</identifier><identifier>DOI: 10.2166/wst.2016.270</identifier><identifier>PMID: 27533865</identifier><language>eng</language><publisher>England: IWA Publishing</publisher><subject>Acids ; Algae ; Algal growth ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Aquatic organisms ; Bio-assays ; Bioassays ; Bioavailability ; Biological Assay ; Chemical analysis ; Chemical properties ; Chemicals ; Chemicophysical properties ; Chemistry ; Colloid chemistry ; Colloids ; Disruption ; Endocrine disruptors ; Endocrine Disruptors - chemistry ; Endocrine Disruptors - pharmacokinetics ; Endocrine Disruptors - toxicity ; Environmental science ; Filtration ; Growth inhibition test ; Humic acids ; Humic Substances - analysis ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; Methods ; Natural environment ; Octylphenol ; Pharmaceuticals ; Phenols - chemistry ; Phenols - toxicity ; Pollutants ; Removal ; Sorption ; Sulfamethoxazole ; Toxicity ; Water Pollutants, Chemical - chemistry ; Xenoestrogens</subject><ispartof>Water science and technology, 2016-08, Vol.74 (4), p.904-913</ispartof><rights>Copyright IWA Publishing Aug 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-e88113fb98d929d46014c9abafb0773cf6359b0e523d5a28779a438ac486e1d83</citedby><cites>FETCH-LOGICAL-c390t-e88113fb98d929d46014c9abafb0773cf6359b0e523d5a28779a438ac486e1d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27533865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Injeong</creatorcontrib><creatorcontrib>Kim, Hyo-Dong</creatorcontrib><creatorcontrib>Jeong, Tae-Yong</creatorcontrib><creatorcontrib>Kim, Sang Don</creatorcontrib><title>Sorption and toxicity reduction of pharmaceutically active compounds and endocrine disrupting chemicals in the presence of colloidal humic acid</title><title>Water science and technology</title><addtitle>Water Sci Technol</addtitle><description>This study investigated the toxicity changes and sorption of pharmaceuticals and endocrine disrupters in the presence of humic acid (HA). For the sorption experiment, a dead end filtration (DEF) system was used to separate bound and free-form target compounds. An algae growth inhibition test and E-screen assay were conducted to estimate the toxic effect of pharmaceutically active compounds (PhACs) and endocrine disrupting chemicals (EDCs), respectively. The permeate concentration was confirmed using liquid chromatography-mass spectrometry. In the sorption test, we observed significant sorption of PhACs and EDCs on colloidal HA, except for sulfamethoxazole (SMX). The values of log KCOC derived from DEF determinations ranged from 4.40 to 5.03. The removal efficiency varied with the HA concentration and the target chemical properties. Tetracycline and 4-octylphenol showed the highest sorption or removal efficiency (≈50%), even at 5 mg C/L HA. The algal growth inhibition of PhACs and the estrogenic effects of EDCs were significantly decreased in proportion to HA concentrations, except for SMX. In addition, the chemical analysis results showed a positive relationship with the bioassay results. Consequently, the sorption of PhACs and EDCs onto colloidal HA should be emphasized in natural environments because it significantly reduces bioavailable concentrations and toxicity to aquatic organisms.</description><subject>Acids</subject><subject>Algae</subject><subject>Algal growth</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Aquatic organisms</subject><subject>Bio-assays</subject><subject>Bioassays</subject><subject>Bioavailability</subject><subject>Biological Assay</subject><subject>Chemical analysis</subject><subject>Chemical properties</subject><subject>Chemicals</subject><subject>Chemicophysical properties</subject><subject>Chemistry</subject><subject>Colloid chemistry</subject><subject>Colloids</subject><subject>Disruption</subject><subject>Endocrine disruptors</subject><subject>Endocrine Disruptors - chemistry</subject><subject>Endocrine Disruptors - pharmacokinetics</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Environmental science</subject><subject>Filtration</subject><subject>Growth inhibition test</subject><subject>Humic acids</subject><subject>Humic Substances - analysis</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Methods</subject><subject>Natural environment</subject><subject>Octylphenol</subject><subject>Pharmaceuticals</subject><subject>Phenols - chemistry</subject><subject>Phenols - toxicity</subject><subject>Pollutants</subject><subject>Removal</subject><subject>Sorption</subject><subject>Sulfamethoxazole</subject><subject>Toxicity</subject><subject>Water Pollutants, Chemical - chemistry</subject><subject>Xenoestrogens</subject><issn>0273-1223</issn><issn>1996-9732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkTtv1TAUgC0EoreFjRlZYmFoLn4kfoyo4iVVYmiZI8c-4bpK7GDHwP0V_OU6bWFg6mTp-DufdPQh9IqSPaNCvPuV1z0jVOyZJE_QjmotGi05e4p2hEneUMb4CTrN-YYQInlLnqMTJjvOleh26M9VTMvqY8AmOLzG39769YgTuGLvxnHEy8Gk2Vgoq7dmmo7Y1K-fgG2cl1iCy3e7EFy0yQfAzudUqjR8x_YA87aUsQ94PQBeEmQIFjavjdMUvTMTPpRKVa13L9CzseLw8uE9Q98-fri--Nxcfv305eL9ZWO5JmsDSlHKx0Erp5l2rSC0tdoMZhyIlNyOgnd6INAx7jrDlJTatFwZ2yoB1Cl-ht7ee5cUfxTIaz_7bGGaTIBYck8V1ZQrTtljUKaUZIRU9M1_6E0sKdRDeqpZJwVt-Uad31M2xZwTjP2S_GzSsaek35r2tWm_Ne1r04q_fpCWYQb3D_4bkd8C3SGe1A</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Kim, Injeong</creator><creator>Kim, Hyo-Dong</creator><creator>Jeong, Tae-Yong</creator><creator>Kim, Sang Don</creator><general>IWA Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H96</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><scope>7ST</scope><scope>7TV</scope><scope>SOI</scope></search><sort><creationdate>20160801</creationdate><title>Sorption and toxicity reduction of pharmaceutically active compounds and endocrine disrupting chemicals in the presence of colloidal humic acid</title><author>Kim, Injeong ; Kim, Hyo-Dong ; Jeong, Tae-Yong ; Kim, Sang Don</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-e88113fb98d929d46014c9abafb0773cf6359b0e523d5a28779a438ac486e1d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acids</topic><topic>Algae</topic><topic>Algal growth</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Aquatic organisms</topic><topic>Bio-assays</topic><topic>Bioassays</topic><topic>Bioavailability</topic><topic>Biological Assay</topic><topic>Chemical analysis</topic><topic>Chemical properties</topic><topic>Chemicals</topic><topic>Chemicophysical properties</topic><topic>Chemistry</topic><topic>Colloid chemistry</topic><topic>Colloids</topic><topic>Disruption</topic><topic>Endocrine disruptors</topic><topic>Endocrine Disruptors - chemistry</topic><topic>Endocrine Disruptors - pharmacokinetics</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Environmental science</topic><topic>Filtration</topic><topic>Growth inhibition test</topic><topic>Humic acids</topic><topic>Humic Substances - analysis</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Methods</topic><topic>Natural environment</topic><topic>Octylphenol</topic><topic>Pharmaceuticals</topic><topic>Phenols - chemistry</topic><topic>Phenols - toxicity</topic><topic>Pollutants</topic><topic>Removal</topic><topic>Sorption</topic><topic>Sulfamethoxazole</topic><topic>Toxicity</topic><topic>Water Pollutants, Chemical - chemistry</topic><topic>Xenoestrogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Injeong</creatorcontrib><creatorcontrib>Kim, Hyo-Dong</creatorcontrib><creatorcontrib>Jeong, Tae-Yong</creatorcontrib><creatorcontrib>Kim, Sang Don</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy & Non-Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Engineering Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Water science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Injeong</au><au>Kim, Hyo-Dong</au><au>Jeong, Tae-Yong</au><au>Kim, Sang Don</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sorption and toxicity reduction of pharmaceutically active compounds and endocrine disrupting chemicals in the presence of colloidal humic acid</atitle><jtitle>Water science and technology</jtitle><addtitle>Water Sci Technol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>74</volume><issue>4</issue><spage>904</spage><epage>913</epage><pages>904-913</pages><issn>0273-1223</issn><eissn>1996-9732</eissn><abstract>This study investigated the toxicity changes and sorption of pharmaceuticals and endocrine disrupters in the presence of humic acid (HA). For the sorption experiment, a dead end filtration (DEF) system was used to separate bound and free-form target compounds. An algae growth inhibition test and E-screen assay were conducted to estimate the toxic effect of pharmaceutically active compounds (PhACs) and endocrine disrupting chemicals (EDCs), respectively. The permeate concentration was confirmed using liquid chromatography-mass spectrometry. In the sorption test, we observed significant sorption of PhACs and EDCs on colloidal HA, except for sulfamethoxazole (SMX). The values of log KCOC derived from DEF determinations ranged from 4.40 to 5.03. The removal efficiency varied with the HA concentration and the target chemical properties. Tetracycline and 4-octylphenol showed the highest sorption or removal efficiency (≈50%), even at 5 mg C/L HA. The algal growth inhibition of PhACs and the estrogenic effects of EDCs were significantly decreased in proportion to HA concentrations, except for SMX. In addition, the chemical analysis results showed a positive relationship with the bioassay results. Consequently, the sorption of PhACs and EDCs onto colloidal HA should be emphasized in natural environments because it significantly reduces bioavailable concentrations and toxicity to aquatic organisms.</abstract><cop>England</cop><pub>IWA Publishing</pub><pmid>27533865</pmid><doi>10.2166/wst.2016.270</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Water science and technology, 2016-08, Vol.74 (4), p.904-913 |
| issn | 0273-1223 1996-9732 |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Acids Algae Algal growth Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Aquatic organisms Bio-assays Bioassays Bioavailability Biological Assay Chemical analysis Chemical properties Chemicals Chemicophysical properties Chemistry Colloid chemistry Colloids Disruption Endocrine disruptors Endocrine Disruptors - chemistry Endocrine Disruptors - pharmacokinetics Endocrine Disruptors - toxicity Environmental science Filtration Growth inhibition test Humic acids Humic Substances - analysis Liquid chromatography Mass spectrometry Mass spectroscopy Methods Natural environment Octylphenol Pharmaceuticals Phenols - chemistry Phenols - toxicity Pollutants Removal Sorption Sulfamethoxazole Toxicity Water Pollutants, Chemical - chemistry Xenoestrogens |
| title | Sorption and toxicity reduction of pharmaceutically active compounds and endocrine disrupting chemicals in the presence of colloidal humic acid |
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