Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation

Notch signaling pathways have recently been implicated in the pathogenesis of metabolic diseases. However, the role of hepatic Notch signaling in glucose and lipid metabolism remains unclear and needs further investigation as it might be a candidate therapeutic target in metabolic diseases such as n...

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Veröffentlicht in:	Laboratory investigation 2016-09, Vol.96 (9), p.972-980
Hauptverfasser:	Bernsmeier, Christine, Dill, Michael T, Provenzano, Angela, Makowska, Zuzanna, Krol, Ilona, Muscogiuri, Giovanna, Semela, David, Tornillo, Luigi, Marra, Fabio, Heim, Markus H, Duong, François H T
Format:	Artikel
Sprache:	eng
Schlagworte:	38/77 631/80 692/163 82/80 Animals Diabetes Mellitus - etiology Diabetes Mellitus - genetics Diet, High-Fat - adverse effects Fatty Liver - etiology Fatty Liver - genetics Gene Expression Profiling - methods Genetic Predisposition to Disease - genetics Glucose-6-Phosphatase - genetics Hepatocytes - metabolism Humans Immunoblotting Laboratory Medicine Liver - metabolism Liver - pathology Medicine Medicine & Public Health Mice, Inbred C57BL Mice, Knockout Non-alcoholic Fatty Liver Disease - genetics Pathology Perilipin-1 - genetics Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptor, Notch1 - deficiency Receptor, Notch1 - genetics research-article Reverse Transcriptase Polymerase Chain Reaction Up-Regulation
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