Effectiveness of subarachnoid drug infusion for pediatric tumor‐related pain
Although the effectiveness of subarachnoid continuous drug infusion has been established in cancer pain management, its clinical use in children is rare. A 14‐year‐old girl with neurofibromatosis type I complained of right leg pain stemming from a growing tumor on her right buttock. Continuous and b...
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| Veröffentlicht in: | Pediatrics international 2016-08, Vol.58 (8), p.760-763 |
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| creator | Higuchi, Tsukasa Shimada, Kazuhiro Cho, Yoshiaki Minami, Kisei Takeuchi, Kouichi Sakamoto, Akiyuki |
| description | Although the effectiveness of subarachnoid continuous drug infusion has been established in cancer pain management, its clinical use in children is rare. A 14‐year‐old girl with neurofibromatosis type I complained of right leg pain stemming from a growing tumor on her right buttock. Continuous and breakthrough right leg pain were unbearable, even at high doses of systemic opioids that caused severe constipation and deep sedation. Subsequent continuous infusion of bupivacaine and morphine through a subarachnoid catheter effectively relieved the girl's pain. The corresponding decrease in systemic opioid also improved her activities of daily living. The patient eventually died of cachexia due to the rapidly growing buttock lesion that was pathologically confirmed post‐mortem as a malignant peripheral nerve sheath tumor. Subarachnoid continuous drug infusion may be very useful in controlling severe pain with few side‐effects, even in the field of pediatric palliative care. |
| doi_str_mv | 10.1111/ped.12952 |
| format | Article |
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A 14‐year‐old girl with neurofibromatosis type I complained of right leg pain stemming from a growing tumor on her right buttock. Continuous and breakthrough right leg pain were unbearable, even at high doses of systemic opioids that caused severe constipation and deep sedation. Subsequent continuous infusion of bupivacaine and morphine through a subarachnoid catheter effectively relieved the girl's pain. The corresponding decrease in systemic opioid also improved her activities of daily living. The patient eventually died of cachexia due to the rapidly growing buttock lesion that was pathologically confirmed post‐mortem as a malignant peripheral nerve sheath tumor. Subarachnoid continuous drug infusion may be very useful in controlling severe pain with few side‐effects, even in the field of pediatric palliative care.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.12952</identifier><identifier>PMID: 27273434</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Activities of daily living ; Adolescent ; Analgesics, Opioid - administration & dosage ; Animal behavior ; Bupivacaine ; Cachexia ; Cancer ; Cancer Pain - diagnosis ; Cancer Pain - drug therapy ; Cancer Pain - etiology ; Children ; Constipation ; Female ; Follow-Up Studies ; Heroin ; Humans ; Injections, Spinal ; Leg ; malignancy ; Medical instruments ; Morphine ; Narcotics ; Neurofibromatosis ; neuropathic pain ; Opioids ; Pain ; Pain Measurement ; Palliative care ; Pediatrics ; Pelvic Neoplasms - complications ; subarachnoid ; Subarachnoid Space</subject><ispartof>Pediatrics international, 2016-08, Vol.58 (8), p.760-763</ispartof><rights>2016 Japan Pediatric Society</rights><rights>2016 Japan Pediatric Society.</rights><rights>Copyright © 2016 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4312-26dc270f0cec6a43d46ed1568fa1fb30248f698d676c5f10e05ff14b470643193</citedby><cites>FETCH-LOGICAL-c4312-26dc270f0cec6a43d46ed1568fa1fb30248f698d676c5f10e05ff14b470643193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.12952$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.12952$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27273434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higuchi, Tsukasa</creatorcontrib><creatorcontrib>Shimada, Kazuhiro</creatorcontrib><creatorcontrib>Cho, Yoshiaki</creatorcontrib><creatorcontrib>Minami, Kisei</creatorcontrib><creatorcontrib>Takeuchi, Kouichi</creatorcontrib><creatorcontrib>Sakamoto, Akiyuki</creatorcontrib><title>Effectiveness of subarachnoid drug infusion for pediatric tumor‐related pain</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Although the effectiveness of subarachnoid continuous drug infusion has been established in cancer pain management, its clinical use in children is rare. A 14‐year‐old girl with neurofibromatosis type I complained of right leg pain stemming from a growing tumor on her right buttock. Continuous and breakthrough right leg pain were unbearable, even at high doses of systemic opioids that caused severe constipation and deep sedation. Subsequent continuous infusion of bupivacaine and morphine through a subarachnoid catheter effectively relieved the girl's pain. The corresponding decrease in systemic opioid also improved her activities of daily living. The patient eventually died of cachexia due to the rapidly growing buttock lesion that was pathologically confirmed post‐mortem as a malignant peripheral nerve sheath tumor. Subarachnoid continuous drug infusion may be very useful in controlling severe pain with few side‐effects, even in the field of pediatric palliative care.</description><subject>Activities of daily living</subject><subject>Adolescent</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Animal behavior</subject><subject>Bupivacaine</subject><subject>Cachexia</subject><subject>Cancer</subject><subject>Cancer Pain - diagnosis</subject><subject>Cancer Pain - drug therapy</subject><subject>Cancer Pain - etiology</subject><subject>Children</subject><subject>Constipation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heroin</subject><subject>Humans</subject><subject>Injections, Spinal</subject><subject>Leg</subject><subject>malignancy</subject><subject>Medical instruments</subject><subject>Morphine</subject><subject>Narcotics</subject><subject>Neurofibromatosis</subject><subject>neuropathic pain</subject><subject>Opioids</subject><subject>Pain</subject><subject>Pain Measurement</subject><subject>Palliative care</subject><subject>Pediatrics</subject><subject>Pelvic Neoplasms - complications</subject><subject>subarachnoid</subject><subject>Subarachnoid Space</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtKBDEQQIMo_hdeQBrc6GLGyqeT9FLG8QODulBwFzLpRCM9nTHpVtx5BM_oSYyObgStTRXF41VRhdAOhiHOcTi39RCTqiRLaB0zRgYE4HY515TIgQQu1tBGSg8AIIVkq2iNCCIoo2wdXYyds6bzT7a1KRXBFamf6qjNfRt8XdSxvyt86_rkQ1u4EIs8y-suelN0_SzE99e3aBvd2bqYa99uoRWnm2S3v_MmujkZX4_OBpPL0_PR0WRgGMV5P14bIsCBsYZrRmvGbY1LLp3GbkqBMOl4JWsuuCkdBgulc5hNmQCeBRXdRPsL7zyGx96mTs18MrZpdGtDnxSWuMJUQAUZ3fuFPoQ-tnk7RTDPUQIV_1HZRWlVgZCZOlhQJoaUonVqHv1MxxeFQX2-QuXzqK9XZHb329hPZ7n7Q_7cPgOHC-DZN_blb5O6Gh8vlB8vSJHE</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Higuchi, Tsukasa</creator><creator>Shimada, Kazuhiro</creator><creator>Cho, Yoshiaki</creator><creator>Minami, Kisei</creator><creator>Takeuchi, Kouichi</creator><creator>Sakamoto, Akiyuki</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>201608</creationdate><title>Effectiveness of subarachnoid drug infusion for pediatric tumor‐related pain</title><author>Higuchi, Tsukasa ; Shimada, Kazuhiro ; Cho, Yoshiaki ; Minami, Kisei ; Takeuchi, Kouichi ; Sakamoto, Akiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4312-26dc270f0cec6a43d46ed1568fa1fb30248f698d676c5f10e05ff14b470643193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Activities of daily living</topic><topic>Adolescent</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Animal behavior</topic><topic>Bupivacaine</topic><topic>Cachexia</topic><topic>Cancer</topic><topic>Cancer Pain - diagnosis</topic><topic>Cancer Pain - drug therapy</topic><topic>Cancer Pain - etiology</topic><topic>Children</topic><topic>Constipation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heroin</topic><topic>Humans</topic><topic>Injections, Spinal</topic><topic>Leg</topic><topic>malignancy</topic><topic>Medical instruments</topic><topic>Morphine</topic><topic>Narcotics</topic><topic>Neurofibromatosis</topic><topic>neuropathic pain</topic><topic>Opioids</topic><topic>Pain</topic><topic>Pain Measurement</topic><topic>Palliative care</topic><topic>Pediatrics</topic><topic>Pelvic Neoplasms - complications</topic><topic>subarachnoid</topic><topic>Subarachnoid Space</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higuchi, Tsukasa</creatorcontrib><creatorcontrib>Shimada, Kazuhiro</creatorcontrib><creatorcontrib>Cho, Yoshiaki</creatorcontrib><creatorcontrib>Minami, Kisei</creatorcontrib><creatorcontrib>Takeuchi, Kouichi</creatorcontrib><creatorcontrib>Sakamoto, Akiyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higuchi, Tsukasa</au><au>Shimada, Kazuhiro</au><au>Cho, Yoshiaki</au><au>Minami, Kisei</au><au>Takeuchi, Kouichi</au><au>Sakamoto, Akiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of subarachnoid drug infusion for pediatric tumor‐related pain</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2016-08</date><risdate>2016</risdate><volume>58</volume><issue>8</issue><spage>760</spage><epage>763</epage><pages>760-763</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Although the effectiveness of subarachnoid continuous drug infusion has been established in cancer pain management, its clinical use in children is rare. A 14‐year‐old girl with neurofibromatosis type I complained of right leg pain stemming from a growing tumor on her right buttock. Continuous and breakthrough right leg pain were unbearable, even at high doses of systemic opioids that caused severe constipation and deep sedation. Subsequent continuous infusion of bupivacaine and morphine through a subarachnoid catheter effectively relieved the girl's pain. The corresponding decrease in systemic opioid also improved her activities of daily living. The patient eventually died of cachexia due to the rapidly growing buttock lesion that was pathologically confirmed post‐mortem as a malignant peripheral nerve sheath tumor. Subarachnoid continuous drug infusion may be very useful in controlling severe pain with few side‐effects, even in the field of pediatric palliative care.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>27273434</pmid><doi>10.1111/ped.12952</doi><tpages>4</tpages></addata></record> |
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| subjects | Activities of daily living Adolescent Analgesics, Opioid - administration & dosage Animal behavior Bupivacaine Cachexia Cancer Cancer Pain - diagnosis Cancer Pain - drug therapy Cancer Pain - etiology Children Constipation Female Follow-Up Studies Heroin Humans Injections, Spinal Leg malignancy Medical instruments Morphine Narcotics Neurofibromatosis neuropathic pain Opioids Pain Pain Measurement Palliative care Pediatrics Pelvic Neoplasms - complications subarachnoid Subarachnoid Space |
| title | Effectiveness of subarachnoid drug infusion for pediatric tumor‐related pain |
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