Long-term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations
Nanoparticles are environmental contaminants of emerging concern. Exposure to engineered nanoparticles has been shown to have detrimental effects on aquatic organisms. The authors synthesized gold nanoparticles (18.1 ± 3.5 nm) and tested their effects on time to and weight at metamorphosis in wood f...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2016-09, Vol.35 (9), p.2304-2310 |
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| container_title | Environmental toxicology and chemistry |
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| creator | Fong, Peter P. Thompson, Lucas B. Carfagno, Gerardo L.F. Sitton, Andrea J. |
| description | Nanoparticles are environmental contaminants of emerging concern. Exposure to engineered nanoparticles has been shown to have detrimental effects on aquatic organisms. The authors synthesized gold nanoparticles (18.1 ± 3.5 nm) and tested their effects on time to and weight at metamorphosis in wood frog (Lithobates sylvaticus) tadpoles, a species known to be sensitive to environmental stressors. Continuous exposure to all concentrations of gold nanoparticles (0.05 pM, 0.5 pM, and 5 pM in particles) for up to 55 d significantly reduced time to metamorphosis by as much as an average of 3 d (p |
| doi_str_mv | 10.1002/etc.3396 |
| format | Article |
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Exposure to engineered nanoparticles has been shown to have detrimental effects on aquatic organisms. The authors synthesized gold nanoparticles (18.1 ± 3.5 nm) and tested their effects on time to and weight at metamorphosis in wood frog (Lithobates sylvaticus) tadpoles, a species known to be sensitive to environmental stressors. Continuous exposure to all concentrations of gold nanoparticles (0.05 pM, 0.5 pM, and 5 pM in particles) for up to 55 d significantly reduced time to metamorphosis by as much as an average of 3 d (p < 0.05). However, exposure to gold nanoparticles had no effect on tadpole mass at metamorphosis. The approximately 18‐nm gold nanoparticles used were metastable in dechlorinated tap water, resulting in a change in surface charge and aggregation over time, leading to negatively charged aggregates that were on the order of 60 nm to 110 nm. Nanoparticle aggregation could exacerbate the effect on time to metamorphosis. To the authors' knowledge, the present study is the first report on the effect of engineered nanoparticles of any kind on life‐history variables in an amphibian, a taxonomic group that has been declining globally for at least 25 yr. Environ Toxicol Chem 2016;35:2304–2310. © 2016 SETAC</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.3396</identifier><identifier>PMID: 26873819</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Amphibians ; Animals ; Anura ; Aquatic ; Aquatic organisms ; Contaminants ; Dose-Response Relationship, Drug ; Drinking water ; Ecotoxicology ; Environmental stress ; Frogs ; Gold - chemistry ; Gold - toxicity ; Larva - drug effects ; Life history ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - toxicity ; Metamorphosis ; Metamorphosis, Biological - drug effects ; Nanomaterials ; Nanoparticles ; Particle Size ; Ranidae ; Surface Properties ; Tadpoles ; Time Factors ; Toxicity ; Water Pollutants, Chemical - chemistry ; Water Pollutants, Chemical - toxicity</subject><ispartof>Environmental toxicology and chemistry, 2016-09, Vol.35 (9), p.2304-2310</ispartof><rights>2016 SETAC</rights><rights>2016 SETAC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5276-78d4eb347c992c837897797b5f91e9127bf8e8eaf5263d0d132632c3f7dd5f53</citedby><cites>FETCH-LOGICAL-c5276-78d4eb347c992c837897797b5f91e9127bf8e8eaf5263d0d132632c3f7dd5f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.3396$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.3396$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26873819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fong, Peter P.</creatorcontrib><creatorcontrib>Thompson, Lucas B.</creatorcontrib><creatorcontrib>Carfagno, Gerardo L.F.</creatorcontrib><creatorcontrib>Sitton, Andrea J.</creatorcontrib><title>Long-term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations</title><title>Environmental toxicology and chemistry</title><addtitle>Environ Toxicol Chem</addtitle><description>Nanoparticles are environmental contaminants of emerging concern. Exposure to engineered nanoparticles has been shown to have detrimental effects on aquatic organisms. The authors synthesized gold nanoparticles (18.1 ± 3.5 nm) and tested their effects on time to and weight at metamorphosis in wood frog (Lithobates sylvaticus) tadpoles, a species known to be sensitive to environmental stressors. Continuous exposure to all concentrations of gold nanoparticles (0.05 pM, 0.5 pM, and 5 pM in particles) for up to 55 d significantly reduced time to metamorphosis by as much as an average of 3 d (p < 0.05). However, exposure to gold nanoparticles had no effect on tadpole mass at metamorphosis. The approximately 18‐nm gold nanoparticles used were metastable in dechlorinated tap water, resulting in a change in surface charge and aggregation over time, leading to negatively charged aggregates that were on the order of 60 nm to 110 nm. Nanoparticle aggregation could exacerbate the effect on time to metamorphosis. To the authors' knowledge, the present study is the first report on the effect of engineered nanoparticles of any kind on life‐history variables in an amphibian, a taxonomic group that has been declining globally for at least 25 yr. Environ Toxicol Chem 2016;35:2304–2310. © 2016 SETAC</description><subject>Amphibians</subject><subject>Animals</subject><subject>Anura</subject><subject>Aquatic</subject><subject>Aquatic organisms</subject><subject>Contaminants</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking water</subject><subject>Ecotoxicology</subject><subject>Environmental stress</subject><subject>Frogs</subject><subject>Gold - chemistry</subject><subject>Gold - toxicity</subject><subject>Larva - drug effects</subject><subject>Life history</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - toxicity</subject><subject>Metamorphosis</subject><subject>Metamorphosis, Biological - drug effects</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Particle Size</subject><subject>Ranidae</subject><subject>Surface Properties</subject><subject>Tadpoles</subject><subject>Time Factors</subject><subject>Toxicity</subject><subject>Water Pollutants, Chemical - chemistry</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVFrFDEQx4Mo9qyCn0ACvtSHrZvkdrN5lENb4VDEoo8hm51cU7PJmmTveh-r39CcPSsIPs0w_PjNMH-EXpL6nNQ1fQtZnzMm2kdoQZqGVl1LusdoUXNWV5y23Ql6ltJNXZNWCPEUnZQRZx0RC3S3Dn5TZYgjhtsppDkCzgFvghuwVz5MKmarHSSstAYHUeXSOxW3yuERshpDnK5DsgnvbL4Oc8bKGNDZ-g0eVUrYerwLYcAmhk3CZ-sD1f-2pL3bqmKf0xusMga_tTH4EXxWzu1xLOu2ymesg9dlWFbb4NNz9MQol-DFsZ6iqw_vr1aX1frzxcfVu3WlG8rbinfDEnq25FoIqjvGO8G54H1jBAFBKO9NBx0o09CWDfVAWKlUM8OHoTENO0Vn99ophp8zpCxHm8oHnPIQ5iRJeR9hTduIgr7-B70Jc_TluAPFKOH1kvwV6hhSimDkFO2o4l6SWh5SlCVFeUixoK-OwrkfYXgA_8RWgOoe2FkH-_-KZGGOwiNvU4bbB17FH7LljDfy-6cL-ZXQZbv6xuQX9gu7M7nQ</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Fong, Peter P.</creator><creator>Thompson, Lucas B.</creator><creator>Carfagno, Gerardo L.F.</creator><creator>Sitton, Andrea J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope></search><sort><creationdate>201609</creationdate><title>Long-term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations</title><author>Fong, Peter P. ; Thompson, Lucas B. ; Carfagno, Gerardo L.F. ; Sitton, Andrea J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5276-78d4eb347c992c837897797b5f91e9127bf8e8eaf5263d0d132632c3f7dd5f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amphibians</topic><topic>Animals</topic><topic>Anura</topic><topic>Aquatic</topic><topic>Aquatic organisms</topic><topic>Contaminants</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drinking water</topic><topic>Ecotoxicology</topic><topic>Environmental stress</topic><topic>Frogs</topic><topic>Gold - chemistry</topic><topic>Gold - toxicity</topic><topic>Larva - drug effects</topic><topic>Life history</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - toxicity</topic><topic>Metamorphosis</topic><topic>Metamorphosis, Biological - drug effects</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Particle Size</topic><topic>Ranidae</topic><topic>Surface Properties</topic><topic>Tadpoles</topic><topic>Time Factors</topic><topic>Toxicity</topic><topic>Water Pollutants, Chemical - chemistry</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fong, Peter P.</creatorcontrib><creatorcontrib>Thompson, Lucas B.</creatorcontrib><creatorcontrib>Carfagno, Gerardo L.F.</creatorcontrib><creatorcontrib>Sitton, Andrea J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fong, Peter P.</au><au>Thompson, Lucas B.</au><au>Carfagno, Gerardo L.F.</au><au>Sitton, Andrea J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environ Toxicol Chem</addtitle><date>2016-09</date><risdate>2016</risdate><volume>35</volume><issue>9</issue><spage>2304</spage><epage>2310</epage><pages>2304-2310</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><abstract>Nanoparticles are environmental contaminants of emerging concern. Exposure to engineered nanoparticles has been shown to have detrimental effects on aquatic organisms. The authors synthesized gold nanoparticles (18.1 ± 3.5 nm) and tested their effects on time to and weight at metamorphosis in wood frog (Lithobates sylvaticus) tadpoles, a species known to be sensitive to environmental stressors. Continuous exposure to all concentrations of gold nanoparticles (0.05 pM, 0.5 pM, and 5 pM in particles) for up to 55 d significantly reduced time to metamorphosis by as much as an average of 3 d (p < 0.05). However, exposure to gold nanoparticles had no effect on tadpole mass at metamorphosis. The approximately 18‐nm gold nanoparticles used were metastable in dechlorinated tap water, resulting in a change in surface charge and aggregation over time, leading to negatively charged aggregates that were on the order of 60 nm to 110 nm. Nanoparticle aggregation could exacerbate the effect on time to metamorphosis. To the authors' knowledge, the present study is the first report on the effect of engineered nanoparticles of any kind on life‐history variables in an amphibian, a taxonomic group that has been declining globally for at least 25 yr. Environ Toxicol Chem 2016;35:2304–2310. © 2016 SETAC</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26873819</pmid><doi>10.1002/etc.3396</doi><tpages>7</tpages></addata></record> |
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| subjects | Amphibians Animals Anura Aquatic Aquatic organisms Contaminants Dose-Response Relationship, Drug Drinking water Ecotoxicology Environmental stress Frogs Gold - chemistry Gold - toxicity Larva - drug effects Life history Metal Nanoparticles - chemistry Metal Nanoparticles - toxicity Metamorphosis Metamorphosis, Biological - drug effects Nanomaterials Nanoparticles Particle Size Ranidae Surface Properties Tadpoles Time Factors Toxicity Water Pollutants, Chemical - chemistry Water Pollutants, Chemical - toxicity |
| title | Long-term exposure to gold nanoparticles accelerates larval metamorphosis without affecting mass in wood frogs (Lithobates sylvaticus) at environmentally relevant concentrations |
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