Effect of mitochondrial calcium uniporter blocking on human spermatozoa

Summary Calcium (Ca2+) regulates a number of essential processes in spermatozoa. Ca2+ is taken up by mitochondria via the mitochondrial calcium uniporter (mCU). Oxygen‐bridged dinuclear ruthenium amine complex (Ru360) has been used to study mCU because it is a potent and specific inhibitor of this c...

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Veröffentlicht in:	Andrologia 2015-08, Vol.47 (6), p.662-668
Hauptverfasser:	Bravo, A., Treulen, F., Uribe, P., Boguen, R., Felmer, R., Villegas, J. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Calcium Calcium Channel Blockers - pharmacology Calcium Channels - drug effects Calcium Channels - physiology Flow Cytometry human sperm function Humans Infertility Male Membrane Potential, Mitochondrial - drug effects mitochondrial calcium uniporter Motility Reactive Oxygen Species - metabolism Ru360 Ruthenium Compounds Sperm Sperm Capacitation - drug effects Sperm Motility - drug effects Spermatozoa - drug effects Spermatozoa - physiology
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