Oral cancer In vivo gene expression profiling assisted by laser capture microdissection and microarray analysis

Large scale gene expression profiling was carried out on laser capture microdissected (LCM) tumor and normal oral epithelial cells and analysed on high-density oligonucleotide microarrays. About 600 genes were found to be oral cancer associated. These oral cancer associated genes include oncogenes,...

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Veröffentlicht in:	Oncogene 2001-09, Vol.20 (43), p.6196-6204
Hauptverfasser:	ALEVIZOS, Ilias, MAHADEVAPPA, Mamatha, KENT, Ralph, DONOFF, R. Bruce, TODD, Randy, CHOU MING YUNG, WARRINGTON, Janet A, WONG, David T. W, ZHANG, Xue, OHYAMA, Hiroe, KOHNO, Yohko, POSNER, Marshall, GALLAGHER, George T, VARVARES, Mark, COHEN, Donald, KIM, Dae
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Carcinogenesis Cathepsin L Cathepsins - biosynthesis Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Collagenases - biosynthesis Cysteine Endopeptidases Databases, Factual DNA microarrays DNA, Complementary - metabolism Down-Regulation Epithelial cells Epithelial Cells - pathology Female Fundamental and applied biological sciences. Psychology Gene expression Humans Hybridization Lasers Male Metastases Metastasis microarrays Middle Aged Models, Biological Molecular and cellular biology Mouth Mucosa - pathology Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Multigene Family Oligonucleotide Array Sequence Analysis Oligonucleotides Oral cancer Reverse Transcriptase Polymerase Chain Reaction RNA polymerase Software Transcription factors Tumors Up-Regulation Urokinase-Type Plasminogen Activator - biosynthesis
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