Green tea polyphenol (–)‐epigallocatechin‐3‐gallate prevents N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced dopaminergic neurodegeneration

In the present study we demonstrate neuroprotective property of green tea extract and (–)‐epigallocatechin‐3‐gallate in N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine mice model of Parkinson's disease. N‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine neurotoxin caused dopamine neuron loss in substant...

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Veröffentlicht in:	Journal of neurochemistry 2001-09, Vol.78 (5), p.1073-1082
Hauptverfasser:	Levites, Yona, Weinreb, Orly, Maor, Gila, Youdim, Moussa B. H., Mandel, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	(–)‐epigallocatechin‐3‐gallate 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Biological and medical sciences Catalase - metabolism Catechin - analogs & derivatives Catechin - pharmacology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - physiology Dopamine Agents epigallocatechin gallate Flavonoids Free Radical Scavengers - pharmacology Immunohistochemistry Medical sciences Mice Mice, Inbred C57BL Monoamine Oxidase - metabolism MPTP Poisoning - drug therapy MPTP Poisoning - metabolism Nerve Degeneration - chemically induced Nerve Degeneration - drug therapy Nerve Degeneration - metabolism neurodegenerative diseases Neurology Neurons - drug effects Neurons - enzymology N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine oxidative stress Oxidative Stress - drug effects Parkinson's disease Phenols - pharmacology Polymers - pharmacology polyphenols Rats Superoxide Dismutase - metabolism Tea - chemistry Tyrosine 3-Monooxygenase - analysis
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