Aging increases the susceptiblity to methamphetamine‐induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia

Methamphetamine (METH) produces dopaminergic neurotoxicity by the production of reactive oxygen (ROS) and nitrogen (RNS) species. The role of free radicals has also been implicated in the process of aging. The present study was designed to evaluate whether METH‐induced dopaminergic neurotoxicity and...

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Veröffentlicht in:	Journal of neurochemistry 2001-09, Vol.78 (5), p.952-959
Hauptverfasser:	Imam, Syed Z., Ali, Syed F.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism aging Aging - metabolism Animals Biological and medical sciences Brain Chemistry - drug effects Brain Chemistry - physiology Central Nervous System Stimulants - toxicity Corpus Striatum - metabolism dopamine Dopamine - metabolism Dose-Response Relationship, Drug Drug addictions Fever - metabolism Homovanillic Acid - metabolism Male Medical sciences methamphetamine Methamphetamine - toxicity Nitrates - metabolism oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology peroxynitrite Rats Rats, Sprague-Dawley reactive nitrogen species Toxicology Tyrosine - analogs & derivatives Tyrosine - metabolism Tyrosine - pharmacology
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