Exploring the glycan interaction in vivo: Future prospects of neo-glycoproteins for diagnostics
Herein the biodistributions and in vivo kinetics of chemically prepared neoglycoproteins are reviewed. Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introd...
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| Veröffentlicht in: | Glycobiology (Oxford) 2016-08, Vol.26 (8), p.804-812 |
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| container_title | Glycobiology (Oxford) |
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| creator | Ogura, Akihiro Kurbangalieva, Almira Tanaka, Katsunori |
| description | Herein the biodistributions and in vivo kinetics of chemically prepared neoglycoproteins are reviewed. Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introduced through intravenous injections, have been analyzed using conventional dissection studies as well as noninvasive methods such as single photon emission computed tomography, positron emission tomography and fluorescence imaging. These studies suggest that glycan-dependent protein distribution kinetics may be useful for pharmacological and diagnostic applications. |
| doi_str_mv | 10.1093/glycob/cww038 |
| format | Article |
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Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introduced through intravenous injections, have been analyzed using conventional dissection studies as well as noninvasive methods such as single photon emission computed tomography, positron emission tomography and fluorescence imaging. These studies suggest that glycan-dependent protein distribution kinetics may be useful for pharmacological and diagnostic applications.</description><subject>Amination</subject><subject>Animals</subject><subject>Carbohydrate Sequence</subject><subject>Cysteine - chemistry</subject><subject>Glycoconjugates - chemistry</subject><subject>Glycoconjugates - metabolism</subject><subject>Glycoconjugates - pharmacokinetics</subject><subject>Glycoproteins - chemistry</subject><subject>Glycoproteins - metabolism</subject><subject>Glycoproteins - pharmacokinetics</subject><subject>Glycosylation</subject><subject>Injections, Intravenous</subject><subject>Lysine - chemistry</subject><subject>Mice</subject><subject>Monosaccharides - chemistry</subject><subject>Monosaccharides - metabolism</subject><subject>Oligosaccharides - chemistry</subject><subject>Oligosaccharides - metabolism</subject><subject>Optical Imaging - methods</subject><subject>Oxidation-Reduction</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Single Photon Emission Computed Tomography Computed Tomography - methods</subject><issn>0959-6658</issn><issn>1460-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDFPwzAQRi0EoqUwsiKPLKF2HDsXNoRaQKrEArPlOE4xSuNgOy3996SkMN3p9PTpu4fQNSV3lBRsvm722pVzvdsRBidoSjNBkjRL2SmakoIXiRAcJugihE9CqKDAz9EkFQWQLCNTJBffXeO8bdc4fhh8SFMttm00Xulo3WHHW7t193jZx94b3HkXOqNjwK7GrXHJb4PhGo1tA66dx5VV69aFaHW4RGe1aoK5Os4Zel8u3h6fk9Xr08vjwyrRrICYpBQqAEWKNAdaEc2YyUTFSM1SBQR4VtbUaJNnFZSl0ZxxTThNTaHrUgAjbIZux9yhyFdvQpQbG7RpGjVU7IOkQEHkwPNsQJMR1cMnwZtadt5ulN9LSuTBqRydytHpwN8co_tyY6p_-k8i-wG9P3Yx</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Ogura, Akihiro</creator><creator>Kurbangalieva, Almira</creator><creator>Tanaka, Katsunori</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Exploring the glycan interaction in vivo: Future prospects of neo-glycoproteins for diagnostics</title><author>Ogura, Akihiro ; Kurbangalieva, Almira ; Tanaka, Katsunori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-218d88a092781d0c33e46d30f32a80854bf1ece74d8bbec535c0512e9cfb68303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amination</topic><topic>Animals</topic><topic>Carbohydrate Sequence</topic><topic>Cysteine - chemistry</topic><topic>Glycoconjugates - chemistry</topic><topic>Glycoconjugates - metabolism</topic><topic>Glycoconjugates - pharmacokinetics</topic><topic>Glycoproteins - chemistry</topic><topic>Glycoproteins - metabolism</topic><topic>Glycoproteins - pharmacokinetics</topic><topic>Glycosylation</topic><topic>Injections, Intravenous</topic><topic>Lysine - chemistry</topic><topic>Mice</topic><topic>Monosaccharides - chemistry</topic><topic>Monosaccharides - metabolism</topic><topic>Oligosaccharides - chemistry</topic><topic>Oligosaccharides - metabolism</topic><topic>Optical Imaging - methods</topic><topic>Oxidation-Reduction</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Single Photon Emission Computed Tomography Computed Tomography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogura, Akihiro</creatorcontrib><creatorcontrib>Kurbangalieva, Almira</creatorcontrib><creatorcontrib>Tanaka, Katsunori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Glycobiology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogura, Akihiro</au><au>Kurbangalieva, Almira</au><au>Tanaka, Katsunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring the glycan interaction in vivo: Future prospects of neo-glycoproteins for diagnostics</atitle><jtitle>Glycobiology (Oxford)</jtitle><addtitle>Glycobiology</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>26</volume><issue>8</issue><spage>804</spage><epage>812</epage><pages>804-812</pages><issn>0959-6658</issn><eissn>1460-2423</eissn><abstract>Herein the biodistributions and in vivo kinetics of chemically prepared neoglycoproteins are reviewed. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amination Animals Carbohydrate Sequence Cysteine - chemistry Glycoconjugates - chemistry Glycoconjugates - metabolism Glycoconjugates - pharmacokinetics Glycoproteins - chemistry Glycoproteins - metabolism Glycoproteins - pharmacokinetics Glycosylation Injections, Intravenous Lysine - chemistry Mice Monosaccharides - chemistry Monosaccharides - metabolism Oligosaccharides - chemistry Oligosaccharides - metabolism Optical Imaging - methods Oxidation-Reduction Positron Emission Tomography Computed Tomography - methods Single Photon Emission Computed Tomography Computed Tomography - methods |
| title | Exploring the glycan interaction in vivo: Future prospects of neo-glycoproteins for diagnostics |
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