Analysis and Neuronal Modeling of the Nonlinear Characteristics of a Local Cardiac Reflex in the Rat
Previous experimental results have suggested the existence of a local cardiac reflex in the rat. In this study, the putative role of such a local reflex in cardiovascular regulation is quantitatively analyzed. A model for the local reflex is developed from anatomical experimental results and physiol...
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| Veröffentlicht in: | Neural computation 2001-10, Vol.13 (10), p.2239-2271 |
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| creator | Vadigepalli, Rajanikanth Doyle, Francis J. Schwaber, James S. |
| description | Previous experimental results have suggested the existence of a local cardiac reflex in the rat. In this study, the putative role of such a local reflex in cardiovascular regulation is quantitatively analyzed. A model for the local reflex is developed from anatomical experimental results and physiological data in the literature. Using this model, a systems-level analysis is conducted. Simulation results indicate that the neuromodulatory mechanism of the local reflex attenuates the nonlinearity of the relationship between cardiac vagal drive and arterial pressure. This behavior is characterized through coherence analysis. Furthermore, the modulation of phase-related characteristics of the cardiovascular system is suggested as a plausible mechanism for the nonlinear attenuation. Based on these results, it is plausible that the functional role of the local reflex is highly robust nonlinear compensation at the heart, which results in less complex dynamics in other parts of the reflex. |
| doi_str_mv | 10.1162/089976601750541796 |
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In this study, the putative role of such a local reflex in cardiovascular regulation is quantitatively analyzed. A model for the local reflex is developed from anatomical experimental results and physiological data in the literature. Using this model, a systems-level analysis is conducted. Simulation results indicate that the neuromodulatory mechanism of the local reflex attenuates the nonlinearity of the relationship between cardiac vagal drive and arterial pressure. This behavior is characterized through coherence analysis. Furthermore, the modulation of phase-related characteristics of the cardiovascular system is suggested as a plausible mechanism for the nonlinear attenuation. 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In this study, the putative role of such a local reflex in cardiovascular regulation is quantitatively analyzed. A model for the local reflex is developed from anatomical experimental results and physiological data in the literature. Using this model, a systems-level analysis is conducted. Simulation results indicate that the neuromodulatory mechanism of the local reflex attenuates the nonlinearity of the relationship between cardiac vagal drive and arterial pressure. This behavior is characterized through coherence analysis. Furthermore, the modulation of phase-related characteristics of the cardiovascular system is suggested as a plausible mechanism for the nonlinear attenuation. Based on these results, it is plausible that the functional role of the local reflex is highly robust nonlinear compensation at the heart, which results in less complex dynamics in other parts of the reflex.</description><subject>Analysis. Health state</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Computer Simulation</subject><subject>Dopamine - physiology</subject><subject>Epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects. Models. Methods</subject><subject>Heart - physiology</subject><subject>Heart Conduction System - physiology</subject><subject>Medical sciences</subject><subject>Models, Neurological</subject><subject>Neurons - physiology</subject><subject>nonlinear systems</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Rats - physiology</subject><subject>Reflex - physiology</subject><subject>Serotonin - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0899-7667</issn><issn>1530-888X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UtLHEEQB_BGInE1-QIeQl_ibUzXzvTrKIsv2ChIArkNNf2ILbPT2j0D7re3113wIOipqeL3r4YqQo6BnQKI-S-mtJZCMJCc8QakFntkBrxmlVLq3xcy24CqCHlADnN-YIwJYPwrOQDgkmmtZsSeDdivc8gUB0tv3JRiadDf0bo-DP9p9HS8d_QmDqV0mOjiHhOa0aWQx2DyBiBdRlNCC0w2oKF3zvfumYbhNXqH4zey77HP7vvuPSJ_L87_LK6q5e3l9eJsWZla67GqrbKItZYGPGhvrHSNdUr4uqt507HOimZujRSdRfAaS8PzRknFywasgPqInGznPqb4NLk8tquQjet7HFyccisBNOdQfwpBgeJcywLnW2hSzDk53z6msMK0boG1myO0749QQj9206du5exbZLf1An7uAOayOJ9wMCG_uYapRvONO926VRjbhzilcpr80c8vZPOb8w</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Vadigepalli, Rajanikanth</creator><creator>Doyle, Francis J.</creator><creator>Schwaber, James S.</creator><general>MIT Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Analysis and Neuronal Modeling of the Nonlinear Characteristics of a Local Cardiac Reflex in the Rat</title><author>Vadigepalli, Rajanikanth ; Doyle, Francis J. ; Schwaber, James S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-3d8daa397c1f19fcd7e4de86f3b354b0bd642dc76bda1f9a0bdf548785175d613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Analysis. Health state</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Computer Simulation</topic><topic>Dopamine - physiology</topic><topic>Epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects. Models. Methods</topic><topic>Heart - physiology</topic><topic>Heart Conduction System - physiology</topic><topic>Medical sciences</topic><topic>Models, Neurological</topic><topic>Neurons - physiology</topic><topic>nonlinear systems</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Rats - physiology</topic><topic>Reflex - physiology</topic><topic>Serotonin - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vadigepalli, Rajanikanth</creatorcontrib><creatorcontrib>Doyle, Francis J.</creatorcontrib><creatorcontrib>Schwaber, James S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neural computation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vadigepalli, Rajanikanth</au><au>Doyle, Francis J.</au><au>Schwaber, James S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis and Neuronal Modeling of the Nonlinear Characteristics of a Local Cardiac Reflex in the Rat</atitle><jtitle>Neural computation</jtitle><addtitle>Neural Comput</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>13</volume><issue>10</issue><spage>2239</spage><epage>2271</epage><pages>2239-2271</pages><issn>0899-7667</issn><eissn>1530-888X</eissn><abstract>Previous experimental results have suggested the existence of a local cardiac reflex in the rat. 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| subjects | Analysis. Health state Animals Biological and medical sciences Computer Simulation Dopamine - physiology Epidemiology Fundamental and applied biological sciences. Psychology General aspects General aspects. Models. Methods Heart - physiology Heart Conduction System - physiology Medical sciences Models, Neurological Neurons - physiology nonlinear systems Public health. Hygiene Public health. Hygiene-occupational medicine Rats - physiology Reflex - physiology Serotonin - physiology Vertebrates: nervous system and sense organs |
| title | Analysis and Neuronal Modeling of the Nonlinear Characteristics of a Local Cardiac Reflex in the Rat |
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