Fertility in premenopausal women post autologous stem cell transplant with BEAM conditioning
There is currently minimal data on fertility outcomes in premenopausal women undergoing autologous stem cell transplant (ASCT) with carmustine, etoposide, cytarabine and melphalan (BEAM) conditioning. A retrospective analysis of fertility outcomes in premenopausal females aged between 18 and 40 yr w...
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| Veröffentlicht in: | European journal of haematology 2016-10, Vol.97 (4), p.348-352 |
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| creator | Lasica, Masa Taylor, Emma Bhattacharyya, Puja Bennett, Ashwini Cooke, Rachel E. Stern, Catharyn Agresta, Franca Ayton, Rosemary Grigg, Andrew |
| description | There is currently minimal data on fertility outcomes in premenopausal women undergoing autologous stem cell transplant (ASCT) with carmustine, etoposide, cytarabine and melphalan (BEAM) conditioning. A retrospective analysis of fertility outcomes in premenopausal females aged between 18 and 40 yr who underwent BEAM/ASCT for lymphoma between 1995 and 2011 was performed at four transplant centres. Of 41 premenopausal women who underwent BEAM conditioning, 25 met the inclusion criteria with the main exclusion criterion being inadequate documentation. Eighteen had Hodgkin lymphoma, and seven had non‐Hodgkin lymphoma. Median number of chemotherapy regimens pretransplant was 2 (1–3). Seventeen women (68%) with a median age at transplant of 25 yr (range 17–33) recovered their menses. The comparative group without recovery was older with a median age of 34 yr (range 20–40) (P = 0.007). Ten patients, with a median age at transplant of 22 yr (range 17–30), had 15 naturally conceived pregnancies. Chemotherapy regimens and lymphoma type did not obviously influence the incidence of menses recovery or conception. The incidence of recovery of menses and fertility in premenopausal women undergoing BEAM/ASCT for lymphoma is substantial. Younger age at transplant correlates with superior fertility outcomes. |
| doi_str_mv | 10.1111/ejh.12737 |
| format | Article |
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A retrospective analysis of fertility outcomes in premenopausal females aged between 18 and 40 yr who underwent BEAM/ASCT for lymphoma between 1995 and 2011 was performed at four transplant centres. Of 41 premenopausal women who underwent BEAM conditioning, 25 met the inclusion criteria with the main exclusion criterion being inadequate documentation. Eighteen had Hodgkin lymphoma, and seven had non‐Hodgkin lymphoma. Median number of chemotherapy regimens pretransplant was 2 (1–3). Seventeen women (68%) with a median age at transplant of 25 yr (range 17–33) recovered their menses. The comparative group without recovery was older with a median age of 34 yr (range 20–40) (P = 0.007). Ten patients, with a median age at transplant of 22 yr (range 17–30), had 15 naturally conceived pregnancies. Chemotherapy regimens and lymphoma type did not obviously influence the incidence of menses recovery or conception. The incidence of recovery of menses and fertility in premenopausal women undergoing BEAM/ASCT for lymphoma is substantial. Younger age at transplant correlates with superior fertility outcomes.</description><identifier>ISSN: 0902-4441</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1111/ejh.12737</identifier><identifier>PMID: 26773518</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; autologous stem cell transplant ; BEAM ; Carmustine - adverse effects ; Carmustine - therapeutic use ; Cytarabine - adverse effects ; Cytarabine - therapeutic use ; Female ; fertility ; Fertility - drug effects ; Hematopoietic Stem Cell Transplantation ; Humans ; lymphoma ; Lymphoma - therapy ; Melphalan - adverse effects ; Melphalan - therapeutic use ; menopause ; Podophyllotoxin - adverse effects ; Podophyllotoxin - therapeutic use ; Premenopause ; Retrospective Studies ; Transplantation Conditioning - adverse effects ; Young Adult</subject><ispartof>European journal of haematology, 2016-10, Vol.97 (4), p.348-352</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4337-4d2717efbb9e2f93f035dec5ad9a3e56cfa76e3beaf84cc07945943129ebf2163</citedby><cites>FETCH-LOGICAL-c4337-4d2717efbb9e2f93f035dec5ad9a3e56cfa76e3beaf84cc07945943129ebf2163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejh.12737$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejh.12737$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26773518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lasica, Masa</creatorcontrib><creatorcontrib>Taylor, Emma</creatorcontrib><creatorcontrib>Bhattacharyya, Puja</creatorcontrib><creatorcontrib>Bennett, Ashwini</creatorcontrib><creatorcontrib>Cooke, Rachel E.</creatorcontrib><creatorcontrib>Stern, Catharyn</creatorcontrib><creatorcontrib>Agresta, Franca</creatorcontrib><creatorcontrib>Ayton, Rosemary</creatorcontrib><creatorcontrib>Grigg, Andrew</creatorcontrib><title>Fertility in premenopausal women post autologous stem cell transplant with BEAM conditioning</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>There is currently minimal data on fertility outcomes in premenopausal women undergoing autologous stem cell transplant (ASCT) with carmustine, etoposide, cytarabine and melphalan (BEAM) conditioning. A retrospective analysis of fertility outcomes in premenopausal females aged between 18 and 40 yr who underwent BEAM/ASCT for lymphoma between 1995 and 2011 was performed at four transplant centres. Of 41 premenopausal women who underwent BEAM conditioning, 25 met the inclusion criteria with the main exclusion criterion being inadequate documentation. Eighteen had Hodgkin lymphoma, and seven had non‐Hodgkin lymphoma. Median number of chemotherapy regimens pretransplant was 2 (1–3). Seventeen women (68%) with a median age at transplant of 25 yr (range 17–33) recovered their menses. The comparative group without recovery was older with a median age of 34 yr (range 20–40) (P = 0.007). Ten patients, with a median age at transplant of 22 yr (range 17–30), had 15 naturally conceived pregnancies. Chemotherapy regimens and lymphoma type did not obviously influence the incidence of menses recovery or conception. The incidence of recovery of menses and fertility in premenopausal women undergoing BEAM/ASCT for lymphoma is substantial. Younger age at transplant correlates with superior fertility outcomes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>autologous stem cell transplant</subject><subject>BEAM</subject><subject>Carmustine - adverse effects</subject><subject>Carmustine - therapeutic use</subject><subject>Cytarabine - adverse effects</subject><subject>Cytarabine - therapeutic use</subject><subject>Female</subject><subject>fertility</subject><subject>Fertility - drug effects</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>lymphoma</subject><subject>Lymphoma - therapy</subject><subject>Melphalan - adverse effects</subject><subject>Melphalan - therapeutic use</subject><subject>menopause</subject><subject>Podophyllotoxin - adverse effects</subject><subject>Podophyllotoxin - therapeutic use</subject><subject>Premenopause</subject><subject>Retrospective Studies</subject><subject>Transplantation Conditioning - adverse effects</subject><subject>Young Adult</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhi1EBQvlwB9APsIh4K_E6yOgZQFRkKAICSFZTjIBQxIH29F2_31NF7h1LqPRPPNq9CC0S8khTXUEry-HlEku19CEFoRkpCBqHU2IIiwTQtBNtBXCKyGEKSo30CYrpOQ5nU7Q0xn4aFsbl9j2ePDQQe8GMwbT4oVLAx5ciNiM0bXu2Y0BhwgdrqBtcfSmD0Nr-ogXNr7gk9nxL1y5vrbRut72zz_Rj8a0AXY--za6P5v9Pj3Prm7mF6fHV1klOJeZqJmkEpqyVMAaxRvC8xqq3NTKcMiLqjGyAF6CaaaiqohUIleCU6agbBgt-DbaX-UO3r2PEKLubPh40fSQXtZ0SqdcUFaQhB6s0Mq7EDw0evC2M36pKdEfMnWSqf_JTOzeZ-xYdlB_k1_2EnC0Aha2heX_k_Ts8vwrMltd2KTxz_eF8W-6SPtcP1zPNblTj3cn81t9y_8CNe2O8g</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Lasica, Masa</creator><creator>Taylor, Emma</creator><creator>Bhattacharyya, Puja</creator><creator>Bennett, Ashwini</creator><creator>Cooke, Rachel E.</creator><creator>Stern, Catharyn</creator><creator>Agresta, Franca</creator><creator>Ayton, Rosemary</creator><creator>Grigg, Andrew</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>Fertility in premenopausal women post autologous stem cell transplant with BEAM conditioning</title><author>Lasica, Masa ; Taylor, Emma ; Bhattacharyya, Puja ; Bennett, Ashwini ; Cooke, Rachel E. ; Stern, Catharyn ; Agresta, Franca ; Ayton, Rosemary ; Grigg, Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4337-4d2717efbb9e2f93f035dec5ad9a3e56cfa76e3beaf84cc07945943129ebf2163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>autologous stem cell transplant</topic><topic>BEAM</topic><topic>Carmustine - adverse effects</topic><topic>Carmustine - therapeutic use</topic><topic>Cytarabine - adverse effects</topic><topic>Cytarabine - therapeutic use</topic><topic>Female</topic><topic>fertility</topic><topic>Fertility - drug effects</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>lymphoma</topic><topic>Lymphoma - therapy</topic><topic>Melphalan - adverse effects</topic><topic>Melphalan - therapeutic use</topic><topic>menopause</topic><topic>Podophyllotoxin - adverse effects</topic><topic>Podophyllotoxin - therapeutic use</topic><topic>Premenopause</topic><topic>Retrospective Studies</topic><topic>Transplantation Conditioning - adverse effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lasica, Masa</creatorcontrib><creatorcontrib>Taylor, Emma</creatorcontrib><creatorcontrib>Bhattacharyya, Puja</creatorcontrib><creatorcontrib>Bennett, Ashwini</creatorcontrib><creatorcontrib>Cooke, Rachel E.</creatorcontrib><creatorcontrib>Stern, Catharyn</creatorcontrib><creatorcontrib>Agresta, Franca</creatorcontrib><creatorcontrib>Ayton, Rosemary</creatorcontrib><creatorcontrib>Grigg, Andrew</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lasica, Masa</au><au>Taylor, Emma</au><au>Bhattacharyya, Puja</au><au>Bennett, Ashwini</au><au>Cooke, Rachel E.</au><au>Stern, Catharyn</au><au>Agresta, Franca</au><au>Ayton, Rosemary</au><au>Grigg, Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fertility in premenopausal women post autologous stem cell transplant with BEAM conditioning</atitle><jtitle>European journal of haematology</jtitle><addtitle>Eur J Haematol</addtitle><date>2016-10</date><risdate>2016</risdate><volume>97</volume><issue>4</issue><spage>348</spage><epage>352</epage><pages>348-352</pages><issn>0902-4441</issn><eissn>1600-0609</eissn><abstract>There is currently minimal data on fertility outcomes in premenopausal women undergoing autologous stem cell transplant (ASCT) with carmustine, etoposide, cytarabine and melphalan (BEAM) conditioning. A retrospective analysis of fertility outcomes in premenopausal females aged between 18 and 40 yr who underwent BEAM/ASCT for lymphoma between 1995 and 2011 was performed at four transplant centres. Of 41 premenopausal women who underwent BEAM conditioning, 25 met the inclusion criteria with the main exclusion criterion being inadequate documentation. Eighteen had Hodgkin lymphoma, and seven had non‐Hodgkin lymphoma. Median number of chemotherapy regimens pretransplant was 2 (1–3). Seventeen women (68%) with a median age at transplant of 25 yr (range 17–33) recovered their menses. The comparative group without recovery was older with a median age of 34 yr (range 20–40) (P = 0.007). Ten patients, with a median age at transplant of 22 yr (range 17–30), had 15 naturally conceived pregnancies. Chemotherapy regimens and lymphoma type did not obviously influence the incidence of menses recovery or conception. The incidence of recovery of menses and fertility in premenopausal women undergoing BEAM/ASCT for lymphoma is substantial. Younger age at transplant correlates with superior fertility outcomes.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26773518</pmid><doi>10.1111/ejh.12737</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use autologous stem cell transplant BEAM Carmustine - adverse effects Carmustine - therapeutic use Cytarabine - adverse effects Cytarabine - therapeutic use Female fertility Fertility - drug effects Hematopoietic Stem Cell Transplantation Humans lymphoma Lymphoma - therapy Melphalan - adverse effects Melphalan - therapeutic use menopause Podophyllotoxin - adverse effects Podophyllotoxin - therapeutic use Premenopause Retrospective Studies Transplantation Conditioning - adverse effects Young Adult |
| title | Fertility in premenopausal women post autologous stem cell transplant with BEAM conditioning |
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