Influence of Coronary Artery Diameter on Intracoronary Transluminal Attenuation Gradient During CT Angiography
Abstract Objectives The goal of this study was to assess the effect of coronary artery diameter on luminal attenuation and the correlation between the transluminal attenuation gradient (TAG) and transluminal diameter gradient (TDG) on computed tomography (CT) coronary angiography. Background Recent...
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| Veröffentlicht in: | JACC. Cardiovascular imaging 2016-09, Vol.9 (9), p.1074-1083 |
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| creator | Park, Eun-Ah, MD, PhD Lee, Whal, MD, PhD Park, Sang Joon, PhD Kim, Yeo Koon, MD Hwang, Ho Young, MD, PhD |
| description | Abstract Objectives The goal of this study was to assess the effect of coronary artery diameter on luminal attenuation and the correlation between the transluminal attenuation gradient (TAG) and transluminal diameter gradient (TDG) on computed tomography (CT) coronary angiography. Background Recent studies have reported promising results of TAG in detecting significant stenosis. However, because of the intrinsic nature of CT reconstruction algorithms, luminal attenuation may be affected by vessel diameter. Methods In this 3-part study, phantom simulating vessels of various diameters immersed in different contrast mixtures were scanned, and intraluminal attenuations were measured. In addition, dynamic volume CT scanning was performed in 3 mongrel dogs (untreated, a stenosis model, and an occlusion model) using 320-row area detector computed tomography and intraluminal attenuations, and TAGs were calculated at each temporal scan and compared. In a separate clinical study, TAGs and TDGs of 152 coronary arteries from 62 patients who underwent 320-row area detector computed tomography coronary angiography and invasive angiography were measured and compared. Results Intraluminal attenuation of phantom vessels gradually decreased along with a decrease in diameter. Animal studies revealed that the peak attenuation of distal smaller coronary arteries did not reach that of proximal larger coronary arteries: 55.2% to 78.1% peak attenuation of proximal coronary arteries. No differences in TAG were found between stenotic and normal left circumflex arteries at temporal scans (all, p > 0.05). The clinical study demonstrated significant correlation between TAG and TDG (r = 0.580; p < 0.0001). Conclusions Intraluminal attenuation was shown to decrease with diminution of vessel diameters. In addition, TAG exhibited a significant correlation with TDG, implying that TAG may be a secondary result because of differences in diameters. |
| doi_str_mv | 10.1016/j.jcmg.2015.10.028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1818338524</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1936878X16302546</els_id><sourcerecordid>1818338524</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-6ea776fadebc238facda0863b014a00f7fd5c569f45c43aa2c339f112a9497753</originalsourceid><addsrcrecordid>eNp9kc2L1EAQxYMo7of7D3iQHL1k7I-kOwERhll3HVjw4Ah7a2o61WPHpHvs7gjz39thdj148FRF8d6D96uieEvJihIqPgyrQU-HFSO0yYcVYe2L4pK2UlSy6ejLvHdcVK1sHy-KqxgHQgQRtXxdXDDJZbbJy8JtnRlndBpLb8qND95BOJXrkDCPWwsT5q30rty6FEA_C3YBXBznyToYy3VK6GZINsvuA_QWXSpv52DdodzsyrU7WH8IcPxxelO8MjBGvHma18X3u8-7zZfq4ev9drN-qHTDaKoEgpTCQI97zXhrQPdAWsH3hNZAiJGmb3QjOlM3uuYATHPeGUoZdHUnZcOvi_fn3GPwv2aMSU02ahxHcOjnqGhLW87bhtVZys5SHXyMAY06BjvljooStXBWg1o4q4Xzcsucs-ndU_68n7D_a3kGmwUfzwLMLX9bDCpqu2DubUCdVO_t__M__WPXo3VWw_gTTxgHP4cMPvdQkSmivi2fXh5NBSesqQX_AxEYpXk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1818338524</pqid></control><display><type>article</type><title>Influence of Coronary Artery Diameter on Intracoronary Transluminal Attenuation Gradient During CT Angiography</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Park, Eun-Ah, MD, PhD ; Lee, Whal, MD, PhD ; Park, Sang Joon, PhD ; Kim, Yeo Koon, MD ; Hwang, Ho Young, MD, PhD</creator><creatorcontrib>Park, Eun-Ah, MD, PhD ; Lee, Whal, MD, PhD ; Park, Sang Joon, PhD ; Kim, Yeo Koon, MD ; Hwang, Ho Young, MD, PhD</creatorcontrib><description>Abstract Objectives The goal of this study was to assess the effect of coronary artery diameter on luminal attenuation and the correlation between the transluminal attenuation gradient (TAG) and transluminal diameter gradient (TDG) on computed tomography (CT) coronary angiography. Background Recent studies have reported promising results of TAG in detecting significant stenosis. However, because of the intrinsic nature of CT reconstruction algorithms, luminal attenuation may be affected by vessel diameter. Methods In this 3-part study, phantom simulating vessels of various diameters immersed in different contrast mixtures were scanned, and intraluminal attenuations were measured. In addition, dynamic volume CT scanning was performed in 3 mongrel dogs (untreated, a stenosis model, and an occlusion model) using 320-row area detector computed tomography and intraluminal attenuations, and TAGs were calculated at each temporal scan and compared. In a separate clinical study, TAGs and TDGs of 152 coronary arteries from 62 patients who underwent 320-row area detector computed tomography coronary angiography and invasive angiography were measured and compared. Results Intraluminal attenuation of phantom vessels gradually decreased along with a decrease in diameter. Animal studies revealed that the peak attenuation of distal smaller coronary arteries did not reach that of proximal larger coronary arteries: 55.2% to 78.1% peak attenuation of proximal coronary arteries. No differences in TAG were found between stenotic and normal left circumflex arteries at temporal scans (all, p > 0.05). The clinical study demonstrated significant correlation between TAG and TDG (r = 0.580; p < 0.0001). Conclusions Intraluminal attenuation was shown to decrease with diminution of vessel diameters. In addition, TAG exhibited a significant correlation with TDG, implying that TAG may be a secondary result because of differences in diameters.</description><identifier>ISSN: 1936-878X</identifier><identifier>EISSN: 1876-7591</identifier><identifier>DOI: 10.1016/j.jcmg.2015.10.028</identifier><identifier>PMID: 27372017</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>320-row area detector CT ; Algorithms ; Animals ; Cardiovascular ; Computed Tomography Angiography - instrumentation ; Coronary Angiography - instrumentation ; Coronary Angiography - methods ; coronary artery disease ; Coronary Artery Disease - diagnostic imaging ; coronary artery stenosis ; Coronary Vessels - diagnostic imaging ; Disease Models, Animal ; Dogs ; Humans ; Multidetector Computed Tomography ; Phantoms, Imaging ; Predictive Value of Tests ; Radiographic Image Interpretation, Computer-Assisted ; Retrospective Studies</subject><ispartof>JACC. Cardiovascular imaging, 2016-09, Vol.9 (9), p.1074-1083</ispartof><rights>American College of Cardiology Foundation</rights><rights>2016 American College of Cardiology Foundation</rights><rights>Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-6ea776fadebc238facda0863b014a00f7fd5c569f45c43aa2c339f112a9497753</citedby><cites>FETCH-LOGICAL-c521t-6ea776fadebc238facda0863b014a00f7fd5c569f45c43aa2c339f112a9497753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcmg.2015.10.028$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27372017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Eun-Ah, MD, PhD</creatorcontrib><creatorcontrib>Lee, Whal, MD, PhD</creatorcontrib><creatorcontrib>Park, Sang Joon, PhD</creatorcontrib><creatorcontrib>Kim, Yeo Koon, MD</creatorcontrib><creatorcontrib>Hwang, Ho Young, MD, PhD</creatorcontrib><title>Influence of Coronary Artery Diameter on Intracoronary Transluminal Attenuation Gradient During CT Angiography</title><title>JACC. Cardiovascular imaging</title><addtitle>JACC Cardiovasc Imaging</addtitle><description>Abstract Objectives The goal of this study was to assess the effect of coronary artery diameter on luminal attenuation and the correlation between the transluminal attenuation gradient (TAG) and transluminal diameter gradient (TDG) on computed tomography (CT) coronary angiography. Background Recent studies have reported promising results of TAG in detecting significant stenosis. However, because of the intrinsic nature of CT reconstruction algorithms, luminal attenuation may be affected by vessel diameter. Methods In this 3-part study, phantom simulating vessels of various diameters immersed in different contrast mixtures were scanned, and intraluminal attenuations were measured. In addition, dynamic volume CT scanning was performed in 3 mongrel dogs (untreated, a stenosis model, and an occlusion model) using 320-row area detector computed tomography and intraluminal attenuations, and TAGs were calculated at each temporal scan and compared. In a separate clinical study, TAGs and TDGs of 152 coronary arteries from 62 patients who underwent 320-row area detector computed tomography coronary angiography and invasive angiography were measured and compared. Results Intraluminal attenuation of phantom vessels gradually decreased along with a decrease in diameter. Animal studies revealed that the peak attenuation of distal smaller coronary arteries did not reach that of proximal larger coronary arteries: 55.2% to 78.1% peak attenuation of proximal coronary arteries. No differences in TAG were found between stenotic and normal left circumflex arteries at temporal scans (all, p > 0.05). The clinical study demonstrated significant correlation between TAG and TDG (r = 0.580; p < 0.0001). Conclusions Intraluminal attenuation was shown to decrease with diminution of vessel diameters. In addition, TAG exhibited a significant correlation with TDG, implying that TAG may be a secondary result because of differences in diameters.</description><subject>320-row area detector CT</subject><subject>Algorithms</subject><subject>Animals</subject><subject>Cardiovascular</subject><subject>Computed Tomography Angiography - instrumentation</subject><subject>Coronary Angiography - instrumentation</subject><subject>Coronary Angiography - methods</subject><subject>coronary artery disease</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>coronary artery stenosis</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Humans</subject><subject>Multidetector Computed Tomography</subject><subject>Phantoms, Imaging</subject><subject>Predictive Value of Tests</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Retrospective Studies</subject><issn>1936-878X</issn><issn>1876-7591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2L1EAQxYMo7of7D3iQHL1k7I-kOwERhll3HVjw4Ah7a2o61WPHpHvs7gjz39thdj148FRF8d6D96uieEvJihIqPgyrQU-HFSO0yYcVYe2L4pK2UlSy6ejLvHdcVK1sHy-KqxgHQgQRtXxdXDDJZbbJy8JtnRlndBpLb8qND95BOJXrkDCPWwsT5q30rty6FEA_C3YBXBznyToYy3VK6GZINsvuA_QWXSpv52DdodzsyrU7WH8IcPxxelO8MjBGvHma18X3u8-7zZfq4ev9drN-qHTDaKoEgpTCQI97zXhrQPdAWsH3hNZAiJGmb3QjOlM3uuYATHPeGUoZdHUnZcOvi_fn3GPwv2aMSU02ahxHcOjnqGhLW87bhtVZys5SHXyMAY06BjvljooStXBWg1o4q4Xzcsucs-ndU_68n7D_a3kGmwUfzwLMLX9bDCpqu2DubUCdVO_t__M__WPXo3VWw_gTTxgHP4cMPvdQkSmivi2fXh5NBSesqQX_AxEYpXk</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Park, Eun-Ah, MD, PhD</creator><creator>Lee, Whal, MD, PhD</creator><creator>Park, Sang Joon, PhD</creator><creator>Kim, Yeo Koon, MD</creator><creator>Hwang, Ho Young, MD, PhD</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Influence of Coronary Artery Diameter on Intracoronary Transluminal Attenuation Gradient During CT Angiography</title><author>Park, Eun-Ah, MD, PhD ; Lee, Whal, MD, PhD ; Park, Sang Joon, PhD ; Kim, Yeo Koon, MD ; Hwang, Ho Young, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-6ea776fadebc238facda0863b014a00f7fd5c569f45c43aa2c339f112a9497753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>320-row area detector CT</topic><topic>Algorithms</topic><topic>Animals</topic><topic>Cardiovascular</topic><topic>Computed Tomography Angiography - instrumentation</topic><topic>Coronary Angiography - instrumentation</topic><topic>Coronary Angiography - methods</topic><topic>coronary artery disease</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>coronary artery stenosis</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Humans</topic><topic>Multidetector Computed Tomography</topic><topic>Phantoms, Imaging</topic><topic>Predictive Value of Tests</topic><topic>Radiographic Image Interpretation, Computer-Assisted</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Eun-Ah, MD, PhD</creatorcontrib><creatorcontrib>Lee, Whal, MD, PhD</creatorcontrib><creatorcontrib>Park, Sang Joon, PhD</creatorcontrib><creatorcontrib>Kim, Yeo Koon, MD</creatorcontrib><creatorcontrib>Hwang, Ho Young, MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JACC. Cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Eun-Ah, MD, PhD</au><au>Lee, Whal, MD, PhD</au><au>Park, Sang Joon, PhD</au><au>Kim, Yeo Koon, MD</au><au>Hwang, Ho Young, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Coronary Artery Diameter on Intracoronary Transluminal Attenuation Gradient During CT Angiography</atitle><jtitle>JACC. Cardiovascular imaging</jtitle><addtitle>JACC Cardiovasc Imaging</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>9</volume><issue>9</issue><spage>1074</spage><epage>1083</epage><pages>1074-1083</pages><issn>1936-878X</issn><eissn>1876-7591</eissn><abstract>Abstract Objectives The goal of this study was to assess the effect of coronary artery diameter on luminal attenuation and the correlation between the transluminal attenuation gradient (TAG) and transluminal diameter gradient (TDG) on computed tomography (CT) coronary angiography. Background Recent studies have reported promising results of TAG in detecting significant stenosis. However, because of the intrinsic nature of CT reconstruction algorithms, luminal attenuation may be affected by vessel diameter. Methods In this 3-part study, phantom simulating vessels of various diameters immersed in different contrast mixtures were scanned, and intraluminal attenuations were measured. In addition, dynamic volume CT scanning was performed in 3 mongrel dogs (untreated, a stenosis model, and an occlusion model) using 320-row area detector computed tomography and intraluminal attenuations, and TAGs were calculated at each temporal scan and compared. In a separate clinical study, TAGs and TDGs of 152 coronary arteries from 62 patients who underwent 320-row area detector computed tomography coronary angiography and invasive angiography were measured and compared. Results Intraluminal attenuation of phantom vessels gradually decreased along with a decrease in diameter. Animal studies revealed that the peak attenuation of distal smaller coronary arteries did not reach that of proximal larger coronary arteries: 55.2% to 78.1% peak attenuation of proximal coronary arteries. No differences in TAG were found between stenotic and normal left circumflex arteries at temporal scans (all, p > 0.05). The clinical study demonstrated significant correlation between TAG and TDG (r = 0.580; p < 0.0001). Conclusions Intraluminal attenuation was shown to decrease with diminution of vessel diameters. In addition, TAG exhibited a significant correlation with TDG, implying that TAG may be a secondary result because of differences in diameters.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27372017</pmid><doi>10.1016/j.jcmg.2015.10.028</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 320-row area detector CT Algorithms Animals Cardiovascular Computed Tomography Angiography - instrumentation Coronary Angiography - instrumentation Coronary Angiography - methods coronary artery disease Coronary Artery Disease - diagnostic imaging coronary artery stenosis Coronary Vessels - diagnostic imaging Disease Models, Animal Dogs Humans Multidetector Computed Tomography Phantoms, Imaging Predictive Value of Tests Radiographic Image Interpretation, Computer-Assisted Retrospective Studies |
| title | Influence of Coronary Artery Diameter on Intracoronary Transluminal Attenuation Gradient During CT Angiography |
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