Possible effects of Phillyrea latifolia on weight loss in rats fed a high-energy diet
Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region in Turkey, is used as medicinal teas for weight loss and hyperglycaemia in folk medicine. Objective The study investigated the possible effects of P. latifolia leaves aqueous extract's on weight loss and bioch...
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| Veröffentlicht in: | Pharmaceutical biology 2016-10, Vol.54 (10), p.1991-1997 |
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| container_end_page | 1997 |
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| container_issue | 10 |
| container_start_page | 1991 |
| container_title | Pharmaceutical biology |
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| creator | Yazici-Tutunis, Secil Gurel-Gurevin, Ebru Ustunova, Savas Demirci-Tansel, Cihan Mericli, Filiz |
| description | Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region in Turkey, is used as medicinal teas for weight loss and hyperglycaemia in folk medicine.
Objective The study investigated the possible effects of P. latifolia leaves aqueous extract's on weight loss and biochemical-histological changes in the rats fed a high-energy diet (HED), also isolated and determined the main phenolic compounds.
Materials and methods Twenty-four male Wistar albino rats were divided into four equal groups such as the HED group fed a HED, the PLE group given only the extract of P. latifolia leaves (220 mg/kg), the HED + PLE group administrated with the extract of leaves (220 mg/kg) after being fed with HED and a control group fed with standard pellet diet.
Results PLE administration caused a remarkable decrement of body weight in the HED + PLE group (p |
| doi_str_mv | 10.3109/13880209.2015.1137952 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_1818337288</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1818337288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-bf20ec9108e27232f0deffeead6e2b2306ab18a8cde4b186edb76ab5af0843923</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMofv8EJUcvXSdJP9KbIn7BgnvQc0jbiRtJG026SP-9Kbt69JQh87wzw0PIBYOFYFBfMyElcKgXHFixYExUdcH3yDGr8jwrGCv3U52YbIaOyEmMHwBQCFEckiNeygJqgGPytvIx2sYhRWOwHSP1hq7W1rkpoKZOj9Z4ZzX1A_1G-74eqUsJagcadKINdlTTdWpkOGB4n2hncTwjB0a7iOe795S8Pdy_3j1ly5fH57vbZdaKshyzxnDAtmYgkVdccAPdfAXqrkTecAGlbpjUsu0wT0WJXVOlr0IbkLmouTglV9u5n8F_bTCOqrexRef0gH4TFZNMClFxKRNabNE2pPsDGvUZbK_DpBio2aj6Napmo2pnNOUudys2TY_dX-pXYQJutoAdjA-9_vbBdWrUk_PBBD20Ns7z_9vxAxj_hak</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1818337288</pqid></control><display><type>article</type><title>Possible effects of Phillyrea latifolia on weight loss in rats fed a high-energy diet</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yazici-Tutunis, Secil ; Gurel-Gurevin, Ebru ; Ustunova, Savas ; Demirci-Tansel, Cihan ; Mericli, Filiz</creator><creatorcontrib>Yazici-Tutunis, Secil ; Gurel-Gurevin, Ebru ; Ustunova, Savas ; Demirci-Tansel, Cihan ; Mericli, Filiz</creatorcontrib><description>Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region in Turkey, is used as medicinal teas for weight loss and hyperglycaemia in folk medicine.
Objective The study investigated the possible effects of P. latifolia leaves aqueous extract's on weight loss and biochemical-histological changes in the rats fed a high-energy diet (HED), also isolated and determined the main phenolic compounds.
Materials and methods Twenty-four male Wistar albino rats were divided into four equal groups such as the HED group fed a HED, the PLE group given only the extract of P. latifolia leaves (220 mg/kg), the HED + PLE group administrated with the extract of leaves (220 mg/kg) after being fed with HED and a control group fed with standard pellet diet.
Results PLE administration caused a remarkable decrement of body weight in the HED + PLE group (p < 0.05). PLE showed an improved effect on structural integrity and decreased leukocyte infiltration in liver and small intestinal tissues. The blood glucose (117.3 mmol/L), leptin (5.6 ng/mL), total cholesterol (61.8 mg/dL) and LDL (9.3 mmol/L) levels were significantly increased in the HED group. PLE administration in the HED group decreased these levels. The levels of HDL (26.8 mmol/L) in the HED + PLE group were higher than both control and HED groups. Chemical composition was investigated and luteolin 7-O-glucoside and chlorogenic acid were determined for the first time in Turkish sample from the EtOAc extract of leaves.
Discussion and conclusion Phillyrea latifolia leaves may have beneficial effects on obesity related cellular problems and may become a good source of antidiabetic medication.</description><identifier>ISSN: 1388-0209</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.3109/13880209.2015.1137952</identifier><identifier>PMID: 26850900</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject><![CDATA[Animals ; Anti-Obesity Agents - isolation & purification ; Anti-Obesity Agents - pharmacology ; Biomarkers - blood ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Chlorogenic Acid - isolation & purification ; Chlorogenic Acid - pharmacology ; Diet, High-Fat ; Disease Models, Animal ; Energy Intake ; Glucosides - isolation & purification ; Glucosides - pharmacology ; High-density lipoprotein ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - pharmacology ; Intestine, Small - drug effects ; Intestine, Small - pathology ; leptin ; Lipids - blood ; liver ; Liver - drug effects ; Liver - pathology ; low-density lipoprotein ; Luteolin - isolation & purification ; Luteolin - pharmacology ; Male ; obesity ; Obesity - blood ; Obesity - etiology ; Obesity - physiopathology ; Obesity - prevention & control ; Oleaceae - chemistry ; Phytotherapy ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Leaves ; Plants, Medicinal ; Rats, Wistar ; small intestine ; Time Factors ; total cholesterol ; Weight Loss - drug effects]]></subject><ispartof>Pharmaceutical biology, 2016-10, Vol.54 (10), p.1991-1997</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-bf20ec9108e27232f0deffeead6e2b2306ab18a8cde4b186edb76ab5af0843923</citedby><cites>FETCH-LOGICAL-c366t-bf20ec9108e27232f0deffeead6e2b2306ab18a8cde4b186edb76ab5af0843923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26850900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yazici-Tutunis, Secil</creatorcontrib><creatorcontrib>Gurel-Gurevin, Ebru</creatorcontrib><creatorcontrib>Ustunova, Savas</creatorcontrib><creatorcontrib>Demirci-Tansel, Cihan</creatorcontrib><creatorcontrib>Mericli, Filiz</creatorcontrib><title>Possible effects of Phillyrea latifolia on weight loss in rats fed a high-energy diet</title><title>Pharmaceutical biology</title><addtitle>Pharm Biol</addtitle><description>Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region in Turkey, is used as medicinal teas for weight loss and hyperglycaemia in folk medicine.
Objective The study investigated the possible effects of P. latifolia leaves aqueous extract's on weight loss and biochemical-histological changes in the rats fed a high-energy diet (HED), also isolated and determined the main phenolic compounds.
Materials and methods Twenty-four male Wistar albino rats were divided into four equal groups such as the HED group fed a HED, the PLE group given only the extract of P. latifolia leaves (220 mg/kg), the HED + PLE group administrated with the extract of leaves (220 mg/kg) after being fed with HED and a control group fed with standard pellet diet.
Results PLE administration caused a remarkable decrement of body weight in the HED + PLE group (p < 0.05). PLE showed an improved effect on structural integrity and decreased leukocyte infiltration in liver and small intestinal tissues. The blood glucose (117.3 mmol/L), leptin (5.6 ng/mL), total cholesterol (61.8 mg/dL) and LDL (9.3 mmol/L) levels were significantly increased in the HED group. PLE administration in the HED group decreased these levels. The levels of HDL (26.8 mmol/L) in the HED + PLE group were higher than both control and HED groups. Chemical composition was investigated and luteolin 7-O-glucoside and chlorogenic acid were determined for the first time in Turkish sample from the EtOAc extract of leaves.
Discussion and conclusion Phillyrea latifolia leaves may have beneficial effects on obesity related cellular problems and may become a good source of antidiabetic medication.</description><subject>Animals</subject><subject>Anti-Obesity Agents - isolation & purification</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Chlorogenic Acid - isolation & purification</subject><subject>Chlorogenic Acid - pharmacology</subject><subject>Diet, High-Fat</subject><subject>Disease Models, Animal</subject><subject>Energy Intake</subject><subject>Glucosides - isolation & purification</subject><subject>Glucosides - pharmacology</subject><subject>High-density lipoprotein</subject><subject>Hypoglycemic Agents - isolation & purification</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Intestine, Small - drug effects</subject><subject>Intestine, Small - pathology</subject><subject>leptin</subject><subject>Lipids - blood</subject><subject>liver</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>low-density lipoprotein</subject><subject>Luteolin - isolation & purification</subject><subject>Luteolin - pharmacology</subject><subject>Male</subject><subject>obesity</subject><subject>Obesity - blood</subject><subject>Obesity - etiology</subject><subject>Obesity - physiopathology</subject><subject>Obesity - prevention & control</subject><subject>Oleaceae - chemistry</subject><subject>Phytotherapy</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves</subject><subject>Plants, Medicinal</subject><subject>Rats, Wistar</subject><subject>small intestine</subject><subject>Time Factors</subject><subject>total cholesterol</subject><subject>Weight Loss - drug effects</subject><issn>1388-0209</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMofv8EJUcvXSdJP9KbIn7BgnvQc0jbiRtJG026SP-9Kbt69JQh87wzw0PIBYOFYFBfMyElcKgXHFixYExUdcH3yDGr8jwrGCv3U52YbIaOyEmMHwBQCFEckiNeygJqgGPytvIx2sYhRWOwHSP1hq7W1rkpoKZOj9Z4ZzX1A_1G-74eqUsJagcadKINdlTTdWpkOGB4n2hncTwjB0a7iOe795S8Pdy_3j1ly5fH57vbZdaKshyzxnDAtmYgkVdccAPdfAXqrkTecAGlbpjUsu0wT0WJXVOlr0IbkLmouTglV9u5n8F_bTCOqrexRef0gH4TFZNMClFxKRNabNE2pPsDGvUZbK_DpBio2aj6Napmo2pnNOUudys2TY_dX-pXYQJutoAdjA-9_vbBdWrUk_PBBD20Ns7z_9vxAxj_hak</recordid><startdate>20161002</startdate><enddate>20161002</enddate><creator>Yazici-Tutunis, Secil</creator><creator>Gurel-Gurevin, Ebru</creator><creator>Ustunova, Savas</creator><creator>Demirci-Tansel, Cihan</creator><creator>Mericli, Filiz</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161002</creationdate><title>Possible effects of Phillyrea latifolia on weight loss in rats fed a high-energy diet</title><author>Yazici-Tutunis, Secil ; Gurel-Gurevin, Ebru ; Ustunova, Savas ; Demirci-Tansel, Cihan ; Mericli, Filiz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-bf20ec9108e27232f0deffeead6e2b2306ab18a8cde4b186edb76ab5af0843923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anti-Obesity Agents - isolation & purification</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Chlorogenic Acid - isolation & purification</topic><topic>Chlorogenic Acid - pharmacology</topic><topic>Diet, High-Fat</topic><topic>Disease Models, Animal</topic><topic>Energy Intake</topic><topic>Glucosides - isolation & purification</topic><topic>Glucosides - pharmacology</topic><topic>High-density lipoprotein</topic><topic>Hypoglycemic Agents - isolation & purification</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Intestine, Small - drug effects</topic><topic>Intestine, Small - pathology</topic><topic>leptin</topic><topic>Lipids - blood</topic><topic>liver</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>low-density lipoprotein</topic><topic>Luteolin - isolation & purification</topic><topic>Luteolin - pharmacology</topic><topic>Male</topic><topic>obesity</topic><topic>Obesity - blood</topic><topic>Obesity - etiology</topic><topic>Obesity - physiopathology</topic><topic>Obesity - prevention & control</topic><topic>Oleaceae - chemistry</topic><topic>Phytotherapy</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves</topic><topic>Plants, Medicinal</topic><topic>Rats, Wistar</topic><topic>small intestine</topic><topic>Time Factors</topic><topic>total cholesterol</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yazici-Tutunis, Secil</creatorcontrib><creatorcontrib>Gurel-Gurevin, Ebru</creatorcontrib><creatorcontrib>Ustunova, Savas</creatorcontrib><creatorcontrib>Demirci-Tansel, Cihan</creatorcontrib><creatorcontrib>Mericli, Filiz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yazici-Tutunis, Secil</au><au>Gurel-Gurevin, Ebru</au><au>Ustunova, Savas</au><au>Demirci-Tansel, Cihan</au><au>Mericli, Filiz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible effects of Phillyrea latifolia on weight loss in rats fed a high-energy diet</atitle><jtitle>Pharmaceutical biology</jtitle><addtitle>Pharm Biol</addtitle><date>2016-10-02</date><risdate>2016</risdate><volume>54</volume><issue>10</issue><spage>1991</spage><epage>1997</epage><pages>1991-1997</pages><issn>1388-0209</issn><eissn>1744-5116</eissn><abstract>Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region in Turkey, is used as medicinal teas for weight loss and hyperglycaemia in folk medicine.
Objective The study investigated the possible effects of P. latifolia leaves aqueous extract's on weight loss and biochemical-histological changes in the rats fed a high-energy diet (HED), also isolated and determined the main phenolic compounds.
Materials and methods Twenty-four male Wistar albino rats were divided into four equal groups such as the HED group fed a HED, the PLE group given only the extract of P. latifolia leaves (220 mg/kg), the HED + PLE group administrated with the extract of leaves (220 mg/kg) after being fed with HED and a control group fed with standard pellet diet.
Results PLE administration caused a remarkable decrement of body weight in the HED + PLE group (p < 0.05). PLE showed an improved effect on structural integrity and decreased leukocyte infiltration in liver and small intestinal tissues. The blood glucose (117.3 mmol/L), leptin (5.6 ng/mL), total cholesterol (61.8 mg/dL) and LDL (9.3 mmol/L) levels were significantly increased in the HED group. PLE administration in the HED group decreased these levels. The levels of HDL (26.8 mmol/L) in the HED + PLE group were higher than both control and HED groups. Chemical composition was investigated and luteolin 7-O-glucoside and chlorogenic acid were determined for the first time in Turkish sample from the EtOAc extract of leaves.
Discussion and conclusion Phillyrea latifolia leaves may have beneficial effects on obesity related cellular problems and may become a good source of antidiabetic medication.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>26850900</pmid><doi>10.3109/13880209.2015.1137952</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Anti-Obesity Agents - isolation & purification Anti-Obesity Agents - pharmacology Biomarkers - blood Blood Glucose - drug effects Blood Glucose - metabolism Chlorogenic Acid - isolation & purification Chlorogenic Acid - pharmacology Diet, High-Fat Disease Models, Animal Energy Intake Glucosides - isolation & purification Glucosides - pharmacology High-density lipoprotein Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Intestine, Small - drug effects Intestine, Small - pathology leptin Lipids - blood liver Liver - drug effects Liver - pathology low-density lipoprotein Luteolin - isolation & purification Luteolin - pharmacology Male obesity Obesity - blood Obesity - etiology Obesity - physiopathology Obesity - prevention & control Oleaceae - chemistry Phytotherapy Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves Plants, Medicinal Rats, Wistar small intestine Time Factors total cholesterol Weight Loss - drug effects |
| title | Possible effects of Phillyrea latifolia on weight loss in rats fed a high-energy diet |
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