Genome-wide methylation analysis of DNMT3B gene isoforms revealed specific methylation profiles in breast cell lines

The goal of this study is to characterize the specific methylation profile triggered by DNMT3B protein isoforms expressed at different levels in breast cell lines. Microarray DNA methylation data were analyzed and associated with functional genome annotation data. A large spectrum of DNMT3B3/DNMT3B2...

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Veröffentlicht in:	Epigenomics 2016-09, Vol.8 (9), p.1209-1226
Hauptverfasser:	Plourde, Karine V, Labrie, Yvan, Ouellette, Geneviève, Pouliot, Marie-Christine, Durocher, Francine
Format:	Artikel
Sprache:	eng
Schlagworte:	Annotations Biotechnology Breast Breast cancer Cell culture Cell lines Cell Proliferation Cluster analysis Clustering CpG Islands Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation DNA Methyltransferase 3B DNA microarrays DNMT3B gene Epigenesis, Genetic Epigenetics Gene expression Gene Expression Regulation, Neoplastic Genomes HEK293 Cells Humans Isoforms MCF-7 Cells Metastasis Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Stem cells Tumorigenesis
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