Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1

Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that belongs to the family of microtubule-associated proteins. Originally identified for its role in neurogenesis, DCLK1 has recently been shown to regulate biological processes outside of the CNS. DCLK1 is among the 15 most common puta...

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Veröffentlicht in:	Structure (London) 2016-09, Vol.24 (9), p.1550-1561
Hauptverfasser:	Patel, Onisha, Dai, Weiwen, Mentzel, Mareike, Griffin, Michael D.W., Serindoux, Juliette, Gay, Yoann, Fischer, Stefanie, Sterle, Shoukat, Kropp, Ashleigh, Burns, Christopher J., Ernst, Matthias, Buchert, Michael, Lucet, Isabelle S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Amino Acid Motifs Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzodiazepinones - chemistry Benzodiazepinones - pharmacology Binding Sites Crystallography, X-Ray Gene Expression HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Microtubules - drug effects Microtubules - metabolism Microtubules - ultrastructure Models, Molecular Mutation Protein Binding Protein Domains Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Structure, Secondary Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Pyrimidines - chemistry Pyrimidines - pharmacology Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Stomach Neoplasms - drug therapy Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - pathology Substrate Specificity Tubulin Modulators - chemistry Tubulin Modulators - pharmacology Xenograft Model Antitumor Assays
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