Conserved Function of Caenorhabditis elegans UNC-30 and Mouse Pitx2 in Controlling GABAergic Neuron Differentiation

We are taking a cross-species approach to identify genes that are required for mammalian GABAergic neuron differentiation. On the basis of homeodomain similarity, the vertebrate Pitx genes appear to be orthologs of unc-30, a Caenorhabditis elegans gene necessary for differentiation of the GABAergic...

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Veröffentlicht in:	The Journal of neuroscience 2001-09, Vol.21 (17), p.6810-6819
Hauptverfasser:	Westmoreland, Joby J, McEwen, Jason, Moore, Billie A, Jin, Yishi, Condie, Brian G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - physiology Binding Sites - physiology Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Conserved Sequence - physiology gamma-Aminobutyric Acid - metabolism Gene Expression - drug effects Genes, Reporter Glutamate Decarboxylase - genetics Glutamate Decarboxylase - metabolism Helminth Proteins - genetics Helminth Proteins - metabolism Helminth Proteins - pharmacology Homeobox Protein PITX2 Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homeodomain Proteins - pharmacology Isoenzymes - genetics Isoenzymes - metabolism Mice Molecular Sequence Data Neuroblastoma - metabolism Neurons - cytology Neurons - drug effects Neurons - metabolism Nuclear Proteins Phenotype Pitx2 gene Promoter Regions, Genetic - physiology Protein Structure, Tertiary - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Sequence Homology, Nucleic Acid Substrate Specificity - genetics Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - pharmacology Transfection Transgenes Unc-30 gene
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