Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation

Orphanin FQ/nociceptin (OFQ/N) has been shown to modulate nociception, responses to stress and anxiety. We investigated OFQ/N function in human immune cells. We find that monocytic U937, T lymphocytic CEM, and MOLT-4 cell lines express OFQ/N binding sites at levels comparable to that of human SH-SY5...

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Veröffentlicht in:	Brain research bulletin 2001-04, Vol.54 (6), p.655-660
Hauptverfasser:	Peluso, Jean, Gavériaux-Ruff, Claire, Matthes, Hans W.D, Filliol, Dominique, Kieffer, Brigitte L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Binding Sites - drug effects Binding Sites - physiology Biological and medical sciences Cell cycle, cell proliferation Cell Division - drug effects Cell Division - physiology Cell Line - cytology Cell Line - drug effects Cell Line - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Cell physiology CHO Cells - drug effects CHO Cells - metabolism Cricetinae Fundamental and applied biological sciences. Psychology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacokinetics Human Humans Immune cells Immune System - cytology Immune System - drug effects Immune System - metabolism Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Molecular and cellular biology Neuroblastoma Nociceptin Nociceptin Receptor Opioid Peptides - immunology Opioid Peptides - metabolism Opioid Peptides - pharmacology ORL-1 receptor ORL1 protein Orphanin FQ/nociceptin Phytohemagglutinins - pharmacology Proliferation Radioligand Assay Receptors, Opioid - drug effects Receptors, Opioid - immunology Receptors, Opioid - metabolism Sulfur Radioisotopes - pharmacology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
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