Multiple Xanthogranulomas in an Adult: Known Entity, New Association
Background: Multiple xanthogranulomas (XGs) in adults are rare, although an increasing number of case reports are being published. The most frequent association is hematologic malignancies, but the majority of cases remain idiopathic, with occasional spontaneous resolution. Objective: The aims of th...
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| Veröffentlicht in: | Journal of cutaneous medicine and surgery 2016-09, Vol.20 (5), p.474-477 |
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| container_title | Journal of cutaneous medicine and surgery |
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| creator | Vadeboncoeur, Sophie Provost, Nathalie |
| description | Background:
Multiple xanthogranulomas (XGs) in adults are rare, although an increasing number of case reports are being published. The most frequent association is hematologic malignancies, but the majority of cases remain idiopathic, with occasional spontaneous resolution.
Objective:
The aims of this report are to describe a case of eruptive XG in a woman with a solid neoplasia who was receiving imatinib and to review the literature.
Methods and Results:
This 33-year-old woman had a gastrointestinal stromal tumor. After undergoing surgical removal and being on imatinib for 1 year, the patient developed multiple slightly erythematous papules with an orange hue on the axillary region, trunk, abdomen, and thighs. A biopsy confirmed the diagnosis of XG.
Conclusion:
This is to the investigators’ knowledge the first case of eruptive XG in the setting of a solid neoplasia. The possibility of drug-induced XG lesions due to imatinib cannot be excluded. This presentation could be added to the list of associations of adult XG. |
| doi_str_mv | 10.1177/1203475416640795 |
| format | Article |
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Multiple xanthogranulomas (XGs) in adults are rare, although an increasing number of case reports are being published. The most frequent association is hematologic malignancies, but the majority of cases remain idiopathic, with occasional spontaneous resolution.
Objective:
The aims of this report are to describe a case of eruptive XG in a woman with a solid neoplasia who was receiving imatinib and to review the literature.
Methods and Results:
This 33-year-old woman had a gastrointestinal stromal tumor. After undergoing surgical removal and being on imatinib for 1 year, the patient developed multiple slightly erythematous papules with an orange hue on the axillary region, trunk, abdomen, and thighs. A biopsy confirmed the diagnosis of XG.
Conclusion:
This is to the investigators’ knowledge the first case of eruptive XG in the setting of a solid neoplasia. The possibility of drug-induced XG lesions due to imatinib cannot be excluded. This presentation could be added to the list of associations of adult XG.</description><identifier>ISSN: 1203-4754</identifier><identifier>EISSN: 1615-7109</identifier><identifier>DOI: 10.1177/1203475416640795</identifier><identifier>PMID: 27006313</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Antineoplastic Agents - adverse effects ; Chemotherapy, Adjuvant - adverse effects ; Drug Eruptions - etiology ; Drug Eruptions - pathology ; Female ; Gastrointestinal Stromal Tumors - drug therapy ; Gastrointestinal Stromal Tumors - surgery ; Granuloma - chemically induced ; Granuloma - pathology ; Histiocytosis, Non-Langerhans-Cell - chemically induced ; Histiocytosis, Non-Langerhans-Cell - pathology ; Humans ; Imatinib Mesylate - adverse effects ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - surgery ; Xanthomatosis - chemically induced ; Xanthomatosis - pathology</subject><ispartof>Journal of cutaneous medicine and surgery, 2016-09, Vol.20 (5), p.474-477</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c360t-8a3403392d486a39e5ede630ddf24ed3178c925b346e082cd79949937729cfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1203475416640795$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1203475416640795$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,782,786,21828,27933,27934,43630,43631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27006313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vadeboncoeur, Sophie</creatorcontrib><creatorcontrib>Provost, Nathalie</creatorcontrib><title>Multiple Xanthogranulomas in an Adult: Known Entity, New Association</title><title>Journal of cutaneous medicine and surgery</title><addtitle>J Cutan Med Surg</addtitle><description>Background:
Multiple xanthogranulomas (XGs) in adults are rare, although an increasing number of case reports are being published. The most frequent association is hematologic malignancies, but the majority of cases remain idiopathic, with occasional spontaneous resolution.
Objective:
The aims of this report are to describe a case of eruptive XG in a woman with a solid neoplasia who was receiving imatinib and to review the literature.
Methods and Results:
This 33-year-old woman had a gastrointestinal stromal tumor. After undergoing surgical removal and being on imatinib for 1 year, the patient developed multiple slightly erythematous papules with an orange hue on the axillary region, trunk, abdomen, and thighs. A biopsy confirmed the diagnosis of XG.
Conclusion:
This is to the investigators’ knowledge the first case of eruptive XG in the setting of a solid neoplasia. The possibility of drug-induced XG lesions due to imatinib cannot be excluded. This presentation could be added to the list of associations of adult XG.</description><subject>Adult</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Chemotherapy, Adjuvant - adverse effects</subject><subject>Drug Eruptions - etiology</subject><subject>Drug Eruptions - pathology</subject><subject>Female</subject><subject>Gastrointestinal Stromal Tumors - drug therapy</subject><subject>Gastrointestinal Stromal Tumors - surgery</subject><subject>Granuloma - chemically induced</subject><subject>Granuloma - pathology</subject><subject>Histiocytosis, Non-Langerhans-Cell - chemically induced</subject><subject>Histiocytosis, Non-Langerhans-Cell - pathology</subject><subject>Humans</subject><subject>Imatinib Mesylate - adverse effects</subject><subject>Stomach Neoplasms - drug therapy</subject><subject>Stomach Neoplasms - surgery</subject><subject>Xanthomatosis - chemically induced</subject><subject>Xanthomatosis - pathology</subject><issn>1203-4754</issn><issn>1615-7109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqWwM6EsSCyBu5xjx2NV8SUVsXRgs9zYKanyUexk4N_jqsCAxHQn3fM-0r2MXSLcIkp5hxkQlzlHIThIlR-xKQrMU4mgjuMez-n-PmFnIWwBADHnp2ySSQBBSFN2_TI2Q71rXPJmuuG933jTjU3fmpDUXWK6ZG4jcM5OKtMEd_E9Z2z1cL9aPKXL18fnxXyZliRgSAtDHIhUZnkhDCmXO-sEgbVVxp0llEWpsnxNXDgostJKpbhSJGWmysrSjN0ctDvff4wuDLqtQ-maxnSuH4PGIho4LzhFFA5o6fsQvKv0ztet8Z8aQe-70X-7iZGrb_u4bp39DfyUEYH0AASzcXrbj76Lz_4v_AKBPmj4</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Vadeboncoeur, Sophie</creator><creator>Provost, Nathalie</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Multiple Xanthogranulomas in an Adult</title><author>Vadeboncoeur, Sophie ; Provost, Nathalie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-8a3403392d486a39e5ede630ddf24ed3178c925b346e082cd79949937729cfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Chemotherapy, Adjuvant - adverse effects</topic><topic>Drug Eruptions - etiology</topic><topic>Drug Eruptions - pathology</topic><topic>Female</topic><topic>Gastrointestinal Stromal Tumors - drug therapy</topic><topic>Gastrointestinal Stromal Tumors - surgery</topic><topic>Granuloma - chemically induced</topic><topic>Granuloma - pathology</topic><topic>Histiocytosis, Non-Langerhans-Cell - chemically induced</topic><topic>Histiocytosis, Non-Langerhans-Cell - pathology</topic><topic>Humans</topic><topic>Imatinib Mesylate - adverse effects</topic><topic>Stomach Neoplasms - drug therapy</topic><topic>Stomach Neoplasms - surgery</topic><topic>Xanthomatosis - chemically induced</topic><topic>Xanthomatosis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vadeboncoeur, Sophie</creatorcontrib><creatorcontrib>Provost, Nathalie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vadeboncoeur, Sophie</au><au>Provost, Nathalie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple Xanthogranulomas in an Adult: Known Entity, New Association</atitle><jtitle>Journal of cutaneous medicine and surgery</jtitle><addtitle>J Cutan Med Surg</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>20</volume><issue>5</issue><spage>474</spage><epage>477</epage><pages>474-477</pages><issn>1203-4754</issn><eissn>1615-7109</eissn><abstract>Background:
Multiple xanthogranulomas (XGs) in adults are rare, although an increasing number of case reports are being published. The most frequent association is hematologic malignancies, but the majority of cases remain idiopathic, with occasional spontaneous resolution.
Objective:
The aims of this report are to describe a case of eruptive XG in a woman with a solid neoplasia who was receiving imatinib and to review the literature.
Methods and Results:
This 33-year-old woman had a gastrointestinal stromal tumor. After undergoing surgical removal and being on imatinib for 1 year, the patient developed multiple slightly erythematous papules with an orange hue on the axillary region, trunk, abdomen, and thighs. A biopsy confirmed the diagnosis of XG.
Conclusion:
This is to the investigators’ knowledge the first case of eruptive XG in the setting of a solid neoplasia. The possibility of drug-induced XG lesions due to imatinib cannot be excluded. This presentation could be added to the list of associations of adult XG.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>27006313</pmid><doi>10.1177/1203475416640795</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| subjects | Adult Antineoplastic Agents - adverse effects Chemotherapy, Adjuvant - adverse effects Drug Eruptions - etiology Drug Eruptions - pathology Female Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - surgery Granuloma - chemically induced Granuloma - pathology Histiocytosis, Non-Langerhans-Cell - chemically induced Histiocytosis, Non-Langerhans-Cell - pathology Humans Imatinib Mesylate - adverse effects Stomach Neoplasms - drug therapy Stomach Neoplasms - surgery Xanthomatosis - chemically induced Xanthomatosis - pathology |
| title | Multiple Xanthogranulomas in an Adult: Known Entity, New Association |
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