Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A₂-IIA

Platelets are anucleated blood elements highly potent at generating extracellular vesicles (EVs) called microparticles (MPs). Whereas EVs are accepted as an important means of intercellular communication, the mechanisms underlying platelet MP internalization in recipient cells are poorly understood....

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-07, Vol.112 (27), p.E3564-E3573
Hauptverfasser:	Duchez, Anne-Claire, Boudreau, Luc H., Naika, Gajendra S., Bollinger, James, Belleannée, Clémence, Cloutier, Nathalie, Laffont, Benoit, Mendoza-Villarroel, Raifish E., Lévesque, Tania, Rollet-Labelle, Emmanuelle, Rousseau, Matthieu, Allaeys, Isabelle, Tremblay, Jacques J., Poubelle, Patrice E., Lambeau, Gérard, Pouliot, Marc, Provost, Patrick, Soulet, Denis, Gelb, Michael H., Boilard, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - metabolism Animals Arachidonate 12-Lipoxygenase - genetics Arachidonate 12-Lipoxygenase - metabolism arthritis Arthritis, Experimental - genetics Arthritis, Experimental - metabolism Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Biological Sciences Blood Platelets - enzymology Blood Platelets - metabolism cell communication Cell Line Cell-Derived Microparticles - enzymology Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - ultrastructure Cells, Cultured Endocytosis endomembrane system Group II Phospholipases A2 - genetics Group II Phospholipases A2 - metabolism Humans Immunoblotting inflammation mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microscopy, Confocal Microscopy, Electron mitochondria Mitochondria - metabolism Mitochondria - ultrastructure neutrophils Neutrophils - metabolism Neutrophils - ultrastructure nucleic acids patients PNAS Plus Reverse Transcriptase Polymerase Chain Reaction RNA - genetics RNA - metabolism Synovial Fluid - metabolism transcription factors transgenic animals
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