Does the preclinical evidence for functional remyelination following myelinating cell engraftment into the injured spinal cord support progression to clinical trials?

This article reviews all historical literature in which rodent-derived myelinating cells have been engrafted into the contused adult rodent spinal cord. From 2500 initial PubMed citations identified, human cells grafts, bone mesenchymal stem cells, olfactory ensheathing cells, non-myelinating cell g...

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Veröffentlicht in:	Experimental neurology 2016-09, Vol.283 (Pt B), p.560-572
Hauptverfasser:	Myers, Scott A., Bankston, Andrew N., Burke, Darlene A., Ohri, Sujata Saraswat, Whittemore, Scott R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clinical Trials as Topic Disease Models, Animal Humans Myelin Sheath - physiology Myelin Sheath - transplantation Neural precursor cells Neural stem progenitor cells Oligodendrocytes Remyelination Schwann cells Spinal Cord Injuries - surgery Spinal cord injury Transplantation
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