Direct Cytoplasmic Delivery and Nuclear Targeting Delivery of HPMA-MT Conjugates in a Microtubules Dependent Fashion

As the hearts of tumor cells, the nucleus is the ultimate target of many chemotherapeutic agents and genes. However, nuclear drug delivery is always hampered by multiple intracellular obstacles, such as low efficiency of lysosome escape and insufficient nuclear trafficking. Herein, an N-(2-hydroxypr...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular pharmaceutics 2016-09, Vol.13 (9), p.3069-3079
Hauptverfasser:	Zhong, Jiaju, Zhu, Xi, Luo, Kui, Li, Lian, Tang, Manlin, Liu, Yanxi, Zhou, Zhou, Huang, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Apoptosis - physiology Cytoplasm - metabolism Fluorescence Recovery After Photobleaching HeLa Cells Humans Methacrylates - chemistry Microtubules - chemistry Microtubules - metabolism Polymers - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!