Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3β inhibition and in neurons

Muscarinic agonists alter the metabolism of amyloid precursor protein, leading to an increase in alpha -secretase cleavage and a decreased production of amyloidogenic peptides; suggesting that these compounds might modify the Alzheimer's disease process. A second therapeutic target in AD is the...

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Veröffentlicht in:	Journal of Neural Transmission 2000-10, Vol.107 (10), p.1201-1212
Hauptverfasser:	FORLENZA, O. V, SPINK, J. M, DAYANANDAN, R, ANDERTON, B. H, OLESEN, O. F, LOVESTONE, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases glycogen synthase kinase 3^b Medical sciences Neurology
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