Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion

Microglial phenotype alternation is a potential novel pathogenic mechanism for cerebral ischemia. Cerebral ischemia induced autophagy aggravates inflammation and neural injury. However, the effect of autophagy in the modulation of microglial phenotype is still unknown. In this study, we investigated...

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Veröffentlicht in:	International immunopharmacology 2016-10, Vol.39, p.140-148
Hauptverfasser:	Xia, Cong-Yuan, Zhang, Shuai, Chu, Shi-Feng, Wang, Zhen-Zhen, Song, Xiu-Yun, Zuo, Wei, Gao, Yan, Yang, Peng-Fei, Chen, Nai-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Chloride - pharmacology Animals Autophagy Autophagy - drug effects Brain Ischemia - immunology Cell Line CREB Cyclic AMP Response Element-Binding Protein - metabolism Mice Microglia - drug effects Microglia - physiology Microglial phenotype Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism NF-kappa B - metabolism NF-κB Nitric Oxide Synthase Type II - metabolism Phenotype Reperfusion Injury - immunology Stroke Transcription Factors - genetics Transcription Factors - metabolism Tumor Necrosis Factor-alpha - metabolism
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