Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial
Background The present study investigated the effectiveness of a Pimpinella anisum–based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single‐blinded randomized trial. Methods Patients with CRS without nasal polyps were random...
Gespeichert in:
| Veröffentlicht in: | International forum of allergy & rhinology 2016-09, Vol.6 (9), p.943-949 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 949 |
|---|---|
| container_issue | 9 |
| container_start_page | 943 |
| container_title | International forum of allergy & rhinology |
| container_volume | 6 |
| creator | Vazifehkah, Shima Shams-Ardekani, Mohammad Reza Kamalinejad, Mohammad Saderhossein, Seyed Mousa Hosseini, Hamed Shams, Seyed Mohammad Abbassi, Shirin Eghtesad, Sareh Saedi, Babak |
| description | Background
The present study investigated the effectiveness of a Pimpinella anisum–based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single‐blinded randomized trial.
Methods
Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops of a P. anisum–based herbal medicine (Sinupim) in each nostril every 12 hours, while those in the second group (n = 22) received 2 puffs of fluticasone nasal spray in each nostril every 12 hours. Both groups used their designated treatments for 4 weeks. Patients were evaluated by the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) at the start of the trial and after the completion of their treatment.
Results
Although both treatments were effective in reducing patients’ symptoms, there were significantly better results in the Sinupim group based on the SNOT‐22 evaluation. Mean changes in computed tomography (CT) scan scoring in Sinupim and fluticasone groups before and after treatment were 2.22 ± 2.94 and 0.76 ± 1.39, respectively, which was significant within both groups (p < 0.05). Postnasal drip and nasal obstruction were more significantly improved in the Sinupim group.
Conclusion
A P. anisum–based herbal medicine may be an effective treatment for sinusitis without polyps. However, its wide acceptance needs further investigation. |
| doi_str_mv | 10.1002/alr.21785 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1817054199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4170587031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4615-55206c08f1a8ad225f5043be48f7ecfe46d16261a81517272ee0982f2def995c3</originalsourceid><addsrcrecordid>eNp1kU9rFDEYh4MottQe_AIS8KKHaZPs5M94K7WtwqJQFL2F7MwbNzWTjEmmdT350c267R4Ec0kgz-_hffkh9JySE0oIOzU-nTAqFX-EDhlpWSM61T7ev6U4QMc535B6OOWcyqfogElGFVP8EP2-uDV-NsXFgKPFBod4Cx4HU-ZkPB5SnLCNCZcEpowQypbq1ykG1-O0diFmF-bsisv4zpV1nEsN5xqdot9M-U1VVuKbB7zyLgw4mTDE0f2CoTqd8c_QE2t8huP7-wh9vrz4dP6uWX68en9-tmz6VlDecM6I6Imy1CgzMMYtJ-1iBa2yEnoLrRioYKL-0rpi3Q-AdIpZNoDtOt4vjtCrnXdK8ccMuejR5R68NwHinDVVVBLe0q6r6Mt_0Js4p1Cn21JCUCKVqtTrHdWnmHMCq6fkRpM2mhK9bUbXZvTfZir74t44r0YY9uRDDxU43QF3zsPm_yZ9trx-UDa7hMsFfu4TJn3XQi4k118-XOll-_Xy7TVnWi7-ACEDp5E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1816610788</pqid></control><display><type>article</type><title>Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Vazifehkah, Shima ; Shams-Ardekani, Mohammad Reza ; Kamalinejad, Mohammad ; Saderhossein, Seyed Mousa ; Hosseini, Hamed ; Shams, Seyed Mohammad ; Abbassi, Shirin ; Eghtesad, Sareh ; Saedi, Babak</creator><creatorcontrib>Vazifehkah, Shima ; Shams-Ardekani, Mohammad Reza ; Kamalinejad, Mohammad ; Saderhossein, Seyed Mousa ; Hosseini, Hamed ; Shams, Seyed Mohammad ; Abbassi, Shirin ; Eghtesad, Sareh ; Saedi, Babak</creatorcontrib><description>Background
The present study investigated the effectiveness of a Pimpinella anisum–based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single‐blinded randomized trial.
Methods
Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops of a P. anisum–based herbal medicine (Sinupim) in each nostril every 12 hours, while those in the second group (n = 22) received 2 puffs of fluticasone nasal spray in each nostril every 12 hours. Both groups used their designated treatments for 4 weeks. Patients were evaluated by the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) at the start of the trial and after the completion of their treatment.
Results
Although both treatments were effective in reducing patients’ symptoms, there were significantly better results in the Sinupim group based on the SNOT‐22 evaluation. Mean changes in computed tomography (CT) scan scoring in Sinupim and fluticasone groups before and after treatment were 2.22 ± 2.94 and 0.76 ± 1.39, respectively, which was significant within both groups (p < 0.05). Postnasal drip and nasal obstruction were more significantly improved in the Sinupim group.
Conclusion
A P. anisum–based herbal medicine may be an effective treatment for sinusitis without polyps. However, its wide acceptance needs further investigation.</description><identifier>ISSN: 2042-6976</identifier><identifier>EISSN: 2042-6984</identifier><identifier>DOI: 10.1002/alr.21785</identifier><identifier>PMID: 27218285</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Chronic Disease ; clinical trial ; Female ; Fluticasone - therapeutic use ; herbal medicine ; Humans ; Iran ; Male ; Medicine, Traditional ; Middle Aged ; Paranasal Sinuses - diagnostic imaging ; Pimpinella ; Pimpinella anisum ; Plant Extracts - adverse effects ; Plant Extracts - therapeutic use ; Plant Oils - adverse effects ; Plant Oils - therapeutic use ; Rhinitis - diagnostic imaging ; Rhinitis - drug therapy ; Seeds ; Single-Blind Method ; sinusitis ; Sinusitis - diagnostic imaging ; Sinusitis - drug therapy ; SNOT-22 ; Tomography, X-Ray Computed ; treatment ; Treatment Outcome ; Young Adult</subject><ispartof>International forum of allergy & rhinology, 2016-09, Vol.6 (9), p.943-949</ispartof><rights>2016 ARS‐AAOA, LLC</rights><rights>2016 ARS-AAOA, LLC.</rights><rights>2016 ARS-AAOA, LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4615-55206c08f1a8ad225f5043be48f7ecfe46d16261a81517272ee0982f2def995c3</citedby><cites>FETCH-LOGICAL-c4615-55206c08f1a8ad225f5043be48f7ecfe46d16261a81517272ee0982f2def995c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falr.21785$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falr.21785$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27218285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vazifehkah, Shima</creatorcontrib><creatorcontrib>Shams-Ardekani, Mohammad Reza</creatorcontrib><creatorcontrib>Kamalinejad, Mohammad</creatorcontrib><creatorcontrib>Saderhossein, Seyed Mousa</creatorcontrib><creatorcontrib>Hosseini, Hamed</creatorcontrib><creatorcontrib>Shams, Seyed Mohammad</creatorcontrib><creatorcontrib>Abbassi, Shirin</creatorcontrib><creatorcontrib>Eghtesad, Sareh</creatorcontrib><creatorcontrib>Saedi, Babak</creatorcontrib><title>Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial</title><title>International forum of allergy & rhinology</title><addtitle>Int Forum Allergy Rhinol</addtitle><description>Background
The present study investigated the effectiveness of a Pimpinella anisum–based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single‐blinded randomized trial.
Methods
Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops of a P. anisum–based herbal medicine (Sinupim) in each nostril every 12 hours, while those in the second group (n = 22) received 2 puffs of fluticasone nasal spray in each nostril every 12 hours. Both groups used their designated treatments for 4 weeks. Patients were evaluated by the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) at the start of the trial and after the completion of their treatment.
Results
Although both treatments were effective in reducing patients’ symptoms, there were significantly better results in the Sinupim group based on the SNOT‐22 evaluation. Mean changes in computed tomography (CT) scan scoring in Sinupim and fluticasone groups before and after treatment were 2.22 ± 2.94 and 0.76 ± 1.39, respectively, which was significant within both groups (p < 0.05). Postnasal drip and nasal obstruction were more significantly improved in the Sinupim group.
Conclusion
A P. anisum–based herbal medicine may be an effective treatment for sinusitis without polyps. However, its wide acceptance needs further investigation.</description><subject>Adult</subject><subject>Chronic Disease</subject><subject>clinical trial</subject><subject>Female</subject><subject>Fluticasone - therapeutic use</subject><subject>herbal medicine</subject><subject>Humans</subject><subject>Iran</subject><subject>Male</subject><subject>Medicine, Traditional</subject><subject>Middle Aged</subject><subject>Paranasal Sinuses - diagnostic imaging</subject><subject>Pimpinella</subject><subject>Pimpinella anisum</subject><subject>Plant Extracts - adverse effects</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Oils - adverse effects</subject><subject>Plant Oils - therapeutic use</subject><subject>Rhinitis - diagnostic imaging</subject><subject>Rhinitis - drug therapy</subject><subject>Seeds</subject><subject>Single-Blind Method</subject><subject>sinusitis</subject><subject>Sinusitis - diagnostic imaging</subject><subject>Sinusitis - drug therapy</subject><subject>SNOT-22</subject><subject>Tomography, X-Ray Computed</subject><subject>treatment</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>2042-6976</issn><issn>2042-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9rFDEYh4MottQe_AIS8KKHaZPs5M94K7WtwqJQFL2F7MwbNzWTjEmmdT350c267R4Ec0kgz-_hffkh9JySE0oIOzU-nTAqFX-EDhlpWSM61T7ev6U4QMc535B6OOWcyqfogElGFVP8EP2-uDV-NsXFgKPFBod4Cx4HU-ZkPB5SnLCNCZcEpowQypbq1ykG1-O0diFmF-bsisv4zpV1nEsN5xqdot9M-U1VVuKbB7zyLgw4mTDE0f2CoTqd8c_QE2t8huP7-wh9vrz4dP6uWX68en9-tmz6VlDecM6I6Imy1CgzMMYtJ-1iBa2yEnoLrRioYKL-0rpi3Q-AdIpZNoDtOt4vjtCrnXdK8ccMuejR5R68NwHinDVVVBLe0q6r6Mt_0Js4p1Cn21JCUCKVqtTrHdWnmHMCq6fkRpM2mhK9bUbXZvTfZir74t44r0YY9uRDDxU43QF3zsPm_yZ9trx-UDa7hMsFfu4TJn3XQi4k118-XOll-_Xy7TVnWi7-ACEDp5E</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Vazifehkah, Shima</creator><creator>Shams-Ardekani, Mohammad Reza</creator><creator>Kamalinejad, Mohammad</creator><creator>Saderhossein, Seyed Mousa</creator><creator>Hosseini, Hamed</creator><creator>Shams, Seyed Mohammad</creator><creator>Abbassi, Shirin</creator><creator>Eghtesad, Sareh</creator><creator>Saedi, Babak</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial</title><author>Vazifehkah, Shima ; Shams-Ardekani, Mohammad Reza ; Kamalinejad, Mohammad ; Saderhossein, Seyed Mousa ; Hosseini, Hamed ; Shams, Seyed Mohammad ; Abbassi, Shirin ; Eghtesad, Sareh ; Saedi, Babak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4615-55206c08f1a8ad225f5043be48f7ecfe46d16261a81517272ee0982f2def995c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Chronic Disease</topic><topic>clinical trial</topic><topic>Female</topic><topic>Fluticasone - therapeutic use</topic><topic>herbal medicine</topic><topic>Humans</topic><topic>Iran</topic><topic>Male</topic><topic>Medicine, Traditional</topic><topic>Middle Aged</topic><topic>Paranasal Sinuses - diagnostic imaging</topic><topic>Pimpinella</topic><topic>Pimpinella anisum</topic><topic>Plant Extracts - adverse effects</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Oils - adverse effects</topic><topic>Plant Oils - therapeutic use</topic><topic>Rhinitis - diagnostic imaging</topic><topic>Rhinitis - drug therapy</topic><topic>Seeds</topic><topic>Single-Blind Method</topic><topic>sinusitis</topic><topic>Sinusitis - diagnostic imaging</topic><topic>Sinusitis - drug therapy</topic><topic>SNOT-22</topic><topic>Tomography, X-Ray Computed</topic><topic>treatment</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vazifehkah, Shima</creatorcontrib><creatorcontrib>Shams-Ardekani, Mohammad Reza</creatorcontrib><creatorcontrib>Kamalinejad, Mohammad</creatorcontrib><creatorcontrib>Saderhossein, Seyed Mousa</creatorcontrib><creatorcontrib>Hosseini, Hamed</creatorcontrib><creatorcontrib>Shams, Seyed Mohammad</creatorcontrib><creatorcontrib>Abbassi, Shirin</creatorcontrib><creatorcontrib>Eghtesad, Sareh</creatorcontrib><creatorcontrib>Saedi, Babak</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International forum of allergy & rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vazifehkah, Shima</au><au>Shams-Ardekani, Mohammad Reza</au><au>Kamalinejad, Mohammad</au><au>Saderhossein, Seyed Mousa</au><au>Hosseini, Hamed</au><au>Shams, Seyed Mohammad</au><au>Abbassi, Shirin</au><au>Eghtesad, Sareh</au><au>Saedi, Babak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial</atitle><jtitle>International forum of allergy & rhinology</jtitle><addtitle>Int Forum Allergy Rhinol</addtitle><date>2016-09</date><risdate>2016</risdate><volume>6</volume><issue>9</issue><spage>943</spage><epage>949</epage><pages>943-949</pages><issn>2042-6976</issn><eissn>2042-6984</eissn><abstract>Background
The present study investigated the effectiveness of a Pimpinella anisum–based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single‐blinded randomized trial.
Methods
Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops of a P. anisum–based herbal medicine (Sinupim) in each nostril every 12 hours, while those in the second group (n = 22) received 2 puffs of fluticasone nasal spray in each nostril every 12 hours. Both groups used their designated treatments for 4 weeks. Patients were evaluated by the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) at the start of the trial and after the completion of their treatment.
Results
Although both treatments were effective in reducing patients’ symptoms, there were significantly better results in the Sinupim group based on the SNOT‐22 evaluation. Mean changes in computed tomography (CT) scan scoring in Sinupim and fluticasone groups before and after treatment were 2.22 ± 2.94 and 0.76 ± 1.39, respectively, which was significant within both groups (p < 0.05). Postnasal drip and nasal obstruction were more significantly improved in the Sinupim group.
Conclusion
A P. anisum–based herbal medicine may be an effective treatment for sinusitis without polyps. However, its wide acceptance needs further investigation.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27218285</pmid><doi>10.1002/alr.21785</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6976 |
| ispartof | International forum of allergy & rhinology, 2016-09, Vol.6 (9), p.943-949 |
| issn | 2042-6976 2042-6984 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1817054199 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Chronic Disease clinical trial Female Fluticasone - therapeutic use herbal medicine Humans Iran Male Medicine, Traditional Middle Aged Paranasal Sinuses - diagnostic imaging Pimpinella Pimpinella anisum Plant Extracts - adverse effects Plant Extracts - therapeutic use Plant Oils - adverse effects Plant Oils - therapeutic use Rhinitis - diagnostic imaging Rhinitis - drug therapy Seeds Single-Blind Method sinusitis Sinusitis - diagnostic imaging Sinusitis - drug therapy SNOT-22 Tomography, X-Ray Computed treatment Treatment Outcome Young Adult |
| title | Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T13%3A15%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20a%20novel%20natural%20drop%20for%20treatment%20of%20chronic%20rhinosinusitis%20without%20nasal%20polyps:%20a%20single%20blind%20randomized%20trial&rft.jtitle=International%20forum%20of%20allergy%20&%20rhinology&rft.au=Vazifehkah,%20Shima&rft.date=2016-09&rft.volume=6&rft.issue=9&rft.spage=943&rft.epage=949&rft.pages=943-949&rft.issn=2042-6976&rft.eissn=2042-6984&rft_id=info:doi/10.1002/alr.21785&rft_dat=%3Cproquest_cross%3E4170587031%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1816610788&rft_id=info:pmid/27218285&rfr_iscdi=true |