Effects of hypocretin–saporin injections into the medial septum on sleep and hippocampal theta

Neurons containing the peptide hypocretin, also known as orexin, were recently implicated in the human sleep disorder narcolepsy. Hypocretin neurons are located only in the lateral hypothalamus from where they innervate virtually the entire brain and spinal cord. This peptide is believed to be invol...

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Veröffentlicht in:	Brain research 2001-09, Vol.913 (1), p.106-115
Hauptverfasser:	Gerashchenko, Dmitry, Salin-Pascual, Rafael, Shiromani, Priyattam J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Choline O-Acetyltransferase - metabolism Cholinergic Agents - pharmacology Cholinergic Fibers - drug effects Cholinergic Fibers - metabolism Cholinergic Fibers - ultrastructure Delta Rhythm - drug effects Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Hypocretin hypocretins Hypothalamic Area, Lateral - cytology Hypothalamic Area, Lateral - drug effects Hypothalamic Area, Lateral - metabolism Immunohistochemistry Immunotoxins - pharmacology Intracellular Signaling Peptides and Proteins Male Medial septum N-Glycosyl Hydrolases Narcolepsy - metabolism Narcolepsy - pathology Narcolepsy - physiopathology Nerve Tissue Proteins - pharmacology Neural Pathways - cytology Neural Pathways - drug effects Neural Pathways - metabolism Neurons - cytology Neurons - drug effects Neurons - metabolism Neuropeptides - metabolism Neurotoxins - pharmacology Orexin Receptors Orexins Parvalbumins - metabolism Plant Proteins - pharmacology Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled Receptors, Neuropeptide - drug effects Receptors, Neuropeptide - metabolism Ribosome Inactivating Proteins, Type 1 saporin Saporins Septal Nuclei - cytology Septal Nuclei - drug effects Septal Nuclei - metabolism Sleep Sleep - drug effects Sleep - physiology Sleep Deprivation - metabolism Sleep Deprivation - physiopathology Sleep. Vigilance Theta rhythm Theta Rhythm - drug effects Toxins, Biological Vertebrates: nervous system and sense organs
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