Proglucagons in vertebrates: Expression and processing of multiple genes in a bony fish

In contrast to mammals, where a single proglucagon (PG) gene encodes three peptides: glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 (GLP-1; GLP-2), many non-mammalian vertebrates carry multiple PG genes. Here, we investigate proglucagon mRNA sequences, their tissue expression and proc...

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Veröffentlicht in:	Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2016-09, Vol.199, p.58-66
Hauptverfasser:	Busby, Ellen R., Mommsen, Thomas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Amino Acid Sequence Animals Base Sequence Differential expression Endocrine pancreas Fishes - genetics Fishes - metabolism Gene Expression Regulation Intestine Organ Specificity Proglucagon Proglucagon - biosynthesis Proglucagon - chemistry Proglucagon - genetics Proglucagon - metabolism Protein Transport RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Nucleic Acid Teleost
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