Tramadol hydrochloride/acetaminophen combination versus non-steroidal anti-inflammatory drug for the treatment of perioperative pain after total knee arthroplasty: A prospective, randomized, open-label clinical trial
While many of the commonly used treatments for perioperative pain after total knee arthroplasty (TKA) have been recognized as effective, there is still insufficient evidence for oral medication. In orthopedics, non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used for perioperative...
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| Veröffentlicht in: | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2016-09, Vol.21 (5), p.625-629 |
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| container_title | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association |
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| creator | Mochizuki, Takeshi Yano, Koichiro Ikari, Katsunori Hiroshima, Ryo Takaoka, Hiromitsu Kawakami, Kosei Koenuma, Naoko Ishibashi, Mina Shirahata, Toshikatsu Momohara, Shigeki |
| description | While many of the commonly used treatments for perioperative pain after total knee arthroplasty (TKA) have been recognized as effective, there is still insufficient evidence for oral medication. In orthopedics, non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used for perioperative pain; however, serious adverse events have been reported. Conversely, tramadol hydrochloride/acetaminophen combination (TRAM/APAP) therapy has been shown to reduce pain, particularly for chronic pain in Japan. This study aimed to determine TRAM/APAP efficacy in comparison with NSAIDs for perioperative pain after TKA.
Two hundred eighty patients were enrolled in this study; 137 patients were treated with TRAM/APAP, and 143 patients were treated with NSAID from postoperative (PO) day 2. The primary endpoint was a comparison between the pain visual analog scale (VAS) change from baseline (PO day 2) and PO day 4, day 7, day 10, and day 14. The second endpoint was the number of days until the patient achieved independence from cane walking.
Analysis of endpoints included 130 and 139 patients in the TRAM/APAP and NSAID groups, respectively. The pain VAS change in the TRAM/APAP group on any of the measurement days was significantly improved compared with the NSAID group (P |
| doi_str_mv | 10.1016/j.jos.2016.07.011 |
| format | Article |
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Two hundred eighty patients were enrolled in this study; 137 patients were treated with TRAM/APAP, and 143 patients were treated with NSAID from postoperative (PO) day 2. The primary endpoint was a comparison between the pain visual analog scale (VAS) change from baseline (PO day 2) and PO day 4, day 7, day 10, and day 14. The second endpoint was the number of days until the patient achieved independence from cane walking.
Analysis of endpoints included 130 and 139 patients in the TRAM/APAP and NSAID groups, respectively. The pain VAS change in the TRAM/APAP group on any of the measurement days was significantly improved compared with the NSAID group (P < 0.01). Similarly, the TRAM/APAP group achieved cane-walking independence significantly faster than the NSAID group (P < 0.01).
Efficacy for perioperative pain management after TKA of TRAM/APAP was shown to be superior to that of NSAID; TRAM/APAP was also effective in improving the progress of rehabilitation.</description><identifier>ISSN: 0949-2658</identifier><identifier>EISSN: 1436-2023</identifier><identifier>DOI: 10.1016/j.jos.2016.07.011</identifier><identifier>PMID: 27531573</identifier><language>eng</language><publisher>Japan: Elsevier B.V</publisher><subject>Acetaminophen - administration & dosage ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Arthroplasty, Replacement, Knee - adverse effects ; Arthroplasty, Replacement, Knee - methods ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Combinations ; Female ; Humans ; Male ; Osteoarthritis, Knee - surgery ; Pain Measurement ; Pain, Postoperative - diagnosis ; Pain, Postoperative - drug therapy ; Patient Satisfaction - statistics & numerical data ; Prospective Studies ; Severity of Illness Index ; Statistics, Nonparametric ; Tramadol - administration & dosage ; Treatment Outcome</subject><ispartof>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2016-09, Vol.21 (5), p.625-629</ispartof><rights>2016 The Japanese Orthopaedic Association</rights><rights>Copyright © 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-ed9e91fed7c6dc52feca8c077931a3768c45e63c86c8a903191c53db9684cf593</citedby><cites>FETCH-LOGICAL-c469t-ed9e91fed7c6dc52feca8c077931a3768c45e63c86c8a903191c53db9684cf593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27531573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mochizuki, Takeshi</creatorcontrib><creatorcontrib>Yano, Koichiro</creatorcontrib><creatorcontrib>Ikari, Katsunori</creatorcontrib><creatorcontrib>Hiroshima, Ryo</creatorcontrib><creatorcontrib>Takaoka, Hiromitsu</creatorcontrib><creatorcontrib>Kawakami, Kosei</creatorcontrib><creatorcontrib>Koenuma, Naoko</creatorcontrib><creatorcontrib>Ishibashi, Mina</creatorcontrib><creatorcontrib>Shirahata, Toshikatsu</creatorcontrib><creatorcontrib>Momohara, Shigeki</creatorcontrib><title>Tramadol hydrochloride/acetaminophen combination versus non-steroidal anti-inflammatory drug for the treatment of perioperative pain after total knee arthroplasty: A prospective, randomized, open-label clinical trial</title><title>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</title><addtitle>J Orthop Sci</addtitle><description>While many of the commonly used treatments for perioperative pain after total knee arthroplasty (TKA) have been recognized as effective, there is still insufficient evidence for oral medication. In orthopedics, non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used for perioperative pain; however, serious adverse events have been reported. Conversely, tramadol hydrochloride/acetaminophen combination (TRAM/APAP) therapy has been shown to reduce pain, particularly for chronic pain in Japan. This study aimed to determine TRAM/APAP efficacy in comparison with NSAIDs for perioperative pain after TKA.
Two hundred eighty patients were enrolled in this study; 137 patients were treated with TRAM/APAP, and 143 patients were treated with NSAID from postoperative (PO) day 2. The primary endpoint was a comparison between the pain visual analog scale (VAS) change from baseline (PO day 2) and PO day 4, day 7, day 10, and day 14. The second endpoint was the number of days until the patient achieved independence from cane walking.
Analysis of endpoints included 130 and 139 patients in the TRAM/APAP and NSAID groups, respectively. The pain VAS change in the TRAM/APAP group on any of the measurement days was significantly improved compared with the NSAID group (P < 0.01). Similarly, the TRAM/APAP group achieved cane-walking independence significantly faster than the NSAID group (P < 0.01).
Efficacy for perioperative pain management after TKA of TRAM/APAP was shown to be superior to that of NSAID; TRAM/APAP was also effective in improving the progress of rehabilitation.</description><subject>Acetaminophen - administration & dosage</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Arthroplasty, Replacement, Knee - adverse effects</subject><subject>Arthroplasty, Replacement, Knee - methods</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Osteoarthritis, Knee - surgery</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - diagnosis</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Patient Satisfaction - statistics & numerical data</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Tramadol - administration & dosage</subject><subject>Treatment Outcome</subject><issn>0949-2658</issn><issn>1436-2023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQRiMEYpqBA7BBXrKY9Nhx4sSwGo34k0ZiM6ytartC3Dh2sJ2WmtNwFm7BbXCrB5ZsbC--78lVr6peMrpllInr_XYf0rYpzy3tt5SxR9WGtVzUDW3442pDZSvrRnTDRfUspT2lrO9k97S6aPqOs67nm-r3fYQZTHBkOpoY9ORCtAavQWOG2fqwTOiJDvPOesg2eHLAmNZEfPB1yhiDNeAI-Gxr60cH8ww5xCMxcf1KxhBJnpDkiJBn9JmE8dfPBaMN5Si8A5IFrCcwFhTJIRfWN49IIOYphsVBysc35IYsMaQF9alxRSJ4E2b7A80VKSBfO9ihI9pZb3Uh5GjBPa-ejOASvni4L6sv79_d336s7z5_-HR7c1frVshco5Eo2Yim18LorhlRw6Bp30vOgPdi0G2HgutB6AEk5Uwy3XGzk2Jo9dhJflm9PnPLF7-vmLKabdLoHHgMa1JsYGIQ7dDwEmXnqC7TpIijWqKdIR4Vo-pkVO1VMapORhXtVTFaOq8e8OtuRvOv8VdhCbw9B7AMebAYVdIWvUZjY1mYMsH-B_8H1lK6Gw</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Mochizuki, Takeshi</creator><creator>Yano, Koichiro</creator><creator>Ikari, Katsunori</creator><creator>Hiroshima, Ryo</creator><creator>Takaoka, Hiromitsu</creator><creator>Kawakami, Kosei</creator><creator>Koenuma, Naoko</creator><creator>Ishibashi, Mina</creator><creator>Shirahata, Toshikatsu</creator><creator>Momohara, Shigeki</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Tramadol hydrochloride/acetaminophen combination versus non-steroidal anti-inflammatory drug for the treatment of perioperative pain after total knee arthroplasty: A prospective, randomized, open-label clinical trial</title><author>Mochizuki, Takeshi ; Yano, Koichiro ; Ikari, Katsunori ; Hiroshima, Ryo ; Takaoka, Hiromitsu ; Kawakami, Kosei ; Koenuma, Naoko ; Ishibashi, Mina ; Shirahata, Toshikatsu ; Momohara, Shigeki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-ed9e91fed7c6dc52feca8c077931a3768c45e63c86c8a903191c53db9684cf593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acetaminophen - administration & dosage</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Arthroplasty, Replacement, Knee - adverse effects</topic><topic>Arthroplasty, Replacement, Knee - methods</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Osteoarthritis, Knee - surgery</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - diagnosis</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Patient Satisfaction - statistics & numerical data</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Tramadol - administration & dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mochizuki, Takeshi</creatorcontrib><creatorcontrib>Yano, Koichiro</creatorcontrib><creatorcontrib>Ikari, Katsunori</creatorcontrib><creatorcontrib>Hiroshima, Ryo</creatorcontrib><creatorcontrib>Takaoka, Hiromitsu</creatorcontrib><creatorcontrib>Kawakami, Kosei</creatorcontrib><creatorcontrib>Koenuma, Naoko</creatorcontrib><creatorcontrib>Ishibashi, Mina</creatorcontrib><creatorcontrib>Shirahata, Toshikatsu</creatorcontrib><creatorcontrib>Momohara, Shigeki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mochizuki, Takeshi</au><au>Yano, Koichiro</au><au>Ikari, Katsunori</au><au>Hiroshima, Ryo</au><au>Takaoka, Hiromitsu</au><au>Kawakami, Kosei</au><au>Koenuma, Naoko</au><au>Ishibashi, Mina</au><au>Shirahata, Toshikatsu</au><au>Momohara, Shigeki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tramadol hydrochloride/acetaminophen combination versus non-steroidal anti-inflammatory drug for the treatment of perioperative pain after total knee arthroplasty: A prospective, randomized, open-label clinical trial</atitle><jtitle>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</jtitle><addtitle>J Orthop Sci</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>21</volume><issue>5</issue><spage>625</spage><epage>629</epage><pages>625-629</pages><issn>0949-2658</issn><eissn>1436-2023</eissn><abstract>While many of the commonly used treatments for perioperative pain after total knee arthroplasty (TKA) have been recognized as effective, there is still insufficient evidence for oral medication. In orthopedics, non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used for perioperative pain; however, serious adverse events have been reported. Conversely, tramadol hydrochloride/acetaminophen combination (TRAM/APAP) therapy has been shown to reduce pain, particularly for chronic pain in Japan. This study aimed to determine TRAM/APAP efficacy in comparison with NSAIDs for perioperative pain after TKA.
Two hundred eighty patients were enrolled in this study; 137 patients were treated with TRAM/APAP, and 143 patients were treated with NSAID from postoperative (PO) day 2. The primary endpoint was a comparison between the pain visual analog scale (VAS) change from baseline (PO day 2) and PO day 4, day 7, day 10, and day 14. The second endpoint was the number of days until the patient achieved independence from cane walking.
Analysis of endpoints included 130 and 139 patients in the TRAM/APAP and NSAID groups, respectively. The pain VAS change in the TRAM/APAP group on any of the measurement days was significantly improved compared with the NSAID group (P < 0.01). Similarly, the TRAM/APAP group achieved cane-walking independence significantly faster than the NSAID group (P < 0.01).
Efficacy for perioperative pain management after TKA of TRAM/APAP was shown to be superior to that of NSAID; TRAM/APAP was also effective in improving the progress of rehabilitation.</abstract><cop>Japan</cop><pub>Elsevier B.V</pub><pmid>27531573</pmid><doi>10.1016/j.jos.2016.07.011</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2016-09, Vol.21 (5), p.625-629 |
| issn | 0949-2658 1436-2023 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acetaminophen - administration & dosage Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Arthroplasty, Replacement, Knee - adverse effects Arthroplasty, Replacement, Knee - methods Dose-Response Relationship, Drug Drug Administration Schedule Drug Combinations Female Humans Male Osteoarthritis, Knee - surgery Pain Measurement Pain, Postoperative - diagnosis Pain, Postoperative - drug therapy Patient Satisfaction - statistics & numerical data Prospective Studies Severity of Illness Index Statistics, Nonparametric Tramadol - administration & dosage Treatment Outcome |
| title | Tramadol hydrochloride/acetaminophen combination versus non-steroidal anti-inflammatory drug for the treatment of perioperative pain after total knee arthroplasty: A prospective, randomized, open-label clinical trial |
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