Myocardial dysfunction identified by three-dimensional speckle tracking echocardiography in type 2 diabetes patients relates to complications of microangiopathy
Abstract Background The clinical effect of diabetic microangiopathy on left ventricular (LV) function is still uncertain. The purpose of this study was to assess the relation between diabetic microvascular complications and comprehensive myocardial deformation measurements using three-dimensional (3...
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| Veröffentlicht in: | Journal of cardiology 2016-10, Vol.68 (4), p.282-287 |
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| creator | Enomoto, Mami, MD Ishizu, Tomoko, MD, PhD, FJCC Seo, Yoshihiro, MD, PhD, FJCC Kameda, Yuri, BSc Suzuki, Hiroaki, MD, PhD Shimano, Hiroshi, MD, PhD Kawakami, Yasushi, MD, PhD Aonuma, Kazutaka, MD, PhD, FJCC |
| description | Abstract Background The clinical effect of diabetic microangiopathy on left ventricular (LV) function is still uncertain. The purpose of this study was to assess the relation between diabetic microvascular complications and comprehensive myocardial deformation measurements using three-dimensional (3D) speckle tracking echocardiography. Methods Seventy-seven asymptomatic patients with type 2 diabetes mellitus (DM) and 35 age-matched healthy control subjects underwent 3D echocardiography. Patients with coronary artery disease or LV ejection fraction |
| doi_str_mv | 10.1016/j.jjcc.2016.03.007 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1816864794</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0914508716300260</els_id><sourcerecordid>1816864794</sourcerecordid><originalsourceid>FETCH-LOGICAL-c545t-ca1af85a1597d0219791c5f321405e0051ad35846168b95125cd7487420c67c23</originalsourceid><addsrcrecordid>eNp9ksGO1SAUhhujce6MvoALw9JNr0ALtIkxMRN1TMa4UNeEezi9l962VKAmfRsfVZo7unDhCgL__8M53ymKF4zuGWXydb_ve4A9z_s9rfaUqkfFjjVKlrWqmsfFjrasLgVt1FVxHWNPqaRtI58WV1yxWlZS7opfn1cPJlhnBmLX2C0TJOcn4ixOyXUOLTmsJJ0CYmndiFPMt1kbZ4TzgCQFA2c3HQnC6RLkj8HMp5W4iaR1RsJJDj9gwkhmk1yOjSTgYLaD5An4cR4cmO3VSHxHRgfBm-nofJaf1mfFk84MEZ8_rDfF9w_vv93elfdfPn66fXdfgqhFKsEw0zXCMNEqSzlrVctAdBVnNRVIqWDGVqKpJZPNoRWMC7CqblTNKUgFvLopXl1y5-B_LBiTHl0EHAYzoV-iZk12ylq1dZbyizR_NMaAnZ6DG01YNaN6I6N7vZHRGxlNK53JZNPLh_zlMKL9a_mDIgveXASYq_zpMOgIuVuA1gWEpK13_89_-48dBjflxg5nXDH2fgmZW65DR66p_rrNxjYaTFaUckmr32z_t3E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1816864794</pqid></control><display><type>article</type><title>Myocardial dysfunction identified by three-dimensional speckle tracking echocardiography in type 2 diabetes patients relates to complications of microangiopathy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Enomoto, Mami, MD ; Ishizu, Tomoko, MD, PhD, FJCC ; Seo, Yoshihiro, MD, PhD, FJCC ; Kameda, Yuri, BSc ; Suzuki, Hiroaki, MD, PhD ; Shimano, Hiroshi, MD, PhD ; Kawakami, Yasushi, MD, PhD ; Aonuma, Kazutaka, MD, PhD, FJCC</creator><creatorcontrib>Enomoto, Mami, MD ; Ishizu, Tomoko, MD, PhD, FJCC ; Seo, Yoshihiro, MD, PhD, FJCC ; Kameda, Yuri, BSc ; Suzuki, Hiroaki, MD, PhD ; Shimano, Hiroshi, MD, PhD ; Kawakami, Yasushi, MD, PhD ; Aonuma, Kazutaka, MD, PhD, FJCC</creatorcontrib><description>Abstract Background The clinical effect of diabetic microangiopathy on left ventricular (LV) function is still uncertain. The purpose of this study was to assess the relation between diabetic microvascular complications and comprehensive myocardial deformation measurements using three-dimensional (3D) speckle tracking echocardiography. Methods Seventy-seven asymptomatic patients with type 2 diabetes mellitus (DM) and 35 age-matched healthy control subjects underwent 3D echocardiography. Patients with coronary artery disease or LV ejection fraction <50% were excluded. Presence of proliferative retinopathy, microalbuminuria as nephropathy, and decreased coefficient of variation of R-R intervals (CVRR) <3% as cardiac autonomic neuropathy were defined as diabetic microvascular complications. Results LV ejection fraction, LV mass index, and global radial strain did not differ between control and DM patients. However, global longitudinal and circumferential strain and endocardial area change ratio were lower in patients with DM than in the controls (−12.0 ± 3.0% vs. −16.2 ± 1.9%, −27.7 ± 7.1% vs. 32.2 ± 5.7%, −37.6 ± 7.6% vs. 44.0 ± 6.2%, respectively, p < 0.001). In DM patients, longitudinal strain is related to CVRR ( R = 0.58, p < 0.001), retinopathy stage, and nephropathy stage. Conclusions Diabetic microangiopathy and its accumulated effects significantly related to subclinical LV dysfunction are characterized by impaired longitudinal shortening.</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2016.03.007</identifier><identifier>PMID: 27146366</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Cardiovascular ; Case-Control Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetic Angiopathies - complications ; Diabetic cardiomyopathy ; Echocardiography, Three-Dimensional - methods ; Female ; Humans ; Male ; Middle Aged ; Myocardial Contraction - physiology ; Myocardial strain ; Three-dimensional echocardiography ; Vascular Stiffness - physiology ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - etiology</subject><ispartof>Journal of cardiology, 2016-10, Vol.68 (4), p.282-287</ispartof><rights>Japanese College of Cardiology</rights><rights>2016 Japanese College of Cardiology</rights><rights>Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-ca1af85a1597d0219791c5f321405e0051ad35846168b95125cd7487420c67c23</citedby><cites>FETCH-LOGICAL-c545t-ca1af85a1597d0219791c5f321405e0051ad35846168b95125cd7487420c67c23</cites><orcidid>0000-0003-3794-899X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0914508716300260$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27146366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Enomoto, Mami, MD</creatorcontrib><creatorcontrib>Ishizu, Tomoko, MD, PhD, FJCC</creatorcontrib><creatorcontrib>Seo, Yoshihiro, MD, PhD, FJCC</creatorcontrib><creatorcontrib>Kameda, Yuri, BSc</creatorcontrib><creatorcontrib>Suzuki, Hiroaki, MD, PhD</creatorcontrib><creatorcontrib>Shimano, Hiroshi, MD, PhD</creatorcontrib><creatorcontrib>Kawakami, Yasushi, MD, PhD</creatorcontrib><creatorcontrib>Aonuma, Kazutaka, MD, PhD, FJCC</creatorcontrib><title>Myocardial dysfunction identified by three-dimensional speckle tracking echocardiography in type 2 diabetes patients relates to complications of microangiopathy</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description>Abstract Background The clinical effect of diabetic microangiopathy on left ventricular (LV) function is still uncertain. The purpose of this study was to assess the relation between diabetic microvascular complications and comprehensive myocardial deformation measurements using three-dimensional (3D) speckle tracking echocardiography. Methods Seventy-seven asymptomatic patients with type 2 diabetes mellitus (DM) and 35 age-matched healthy control subjects underwent 3D echocardiography. Patients with coronary artery disease or LV ejection fraction <50% were excluded. Presence of proliferative retinopathy, microalbuminuria as nephropathy, and decreased coefficient of variation of R-R intervals (CVRR) <3% as cardiac autonomic neuropathy were defined as diabetic microvascular complications. Results LV ejection fraction, LV mass index, and global radial strain did not differ between control and DM patients. However, global longitudinal and circumferential strain and endocardial area change ratio were lower in patients with DM than in the controls (−12.0 ± 3.0% vs. −16.2 ± 1.9%, −27.7 ± 7.1% vs. 32.2 ± 5.7%, −37.6 ± 7.6% vs. 44.0 ± 6.2%, respectively, p < 0.001). In DM patients, longitudinal strain is related to CVRR ( R = 0.58, p < 0.001), retinopathy stage, and nephropathy stage. Conclusions Diabetic microangiopathy and its accumulated effects significantly related to subclinical LV dysfunction are characterized by impaired longitudinal shortening.</description><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Angiopathies - complications</subject><subject>Diabetic cardiomyopathy</subject><subject>Echocardiography, Three-Dimensional - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardial strain</subject><subject>Three-dimensional echocardiography</subject><subject>Vascular Stiffness - physiology</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - etiology</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ksGO1SAUhhujce6MvoALw9JNr0ALtIkxMRN1TMa4UNeEezi9l962VKAmfRsfVZo7unDhCgL__8M53ymKF4zuGWXydb_ve4A9z_s9rfaUqkfFjjVKlrWqmsfFjrasLgVt1FVxHWNPqaRtI58WV1yxWlZS7opfn1cPJlhnBmLX2C0TJOcn4ixOyXUOLTmsJJ0CYmndiFPMt1kbZ4TzgCQFA2c3HQnC6RLkj8HMp5W4iaR1RsJJDj9gwkhmk1yOjSTgYLaD5An4cR4cmO3VSHxHRgfBm-nofJaf1mfFk84MEZ8_rDfF9w_vv93elfdfPn66fXdfgqhFKsEw0zXCMNEqSzlrVctAdBVnNRVIqWDGVqKpJZPNoRWMC7CqblTNKUgFvLopXl1y5-B_LBiTHl0EHAYzoV-iZk12ylq1dZbyizR_NMaAnZ6DG01YNaN6I6N7vZHRGxlNK53JZNPLh_zlMKL9a_mDIgveXASYq_zpMOgIuVuA1gWEpK13_89_-48dBjflxg5nXDH2fgmZW65DR66p_rrNxjYaTFaUckmr32z_t3E</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Enomoto, Mami, MD</creator><creator>Ishizu, Tomoko, MD, PhD, FJCC</creator><creator>Seo, Yoshihiro, MD, PhD, FJCC</creator><creator>Kameda, Yuri, BSc</creator><creator>Suzuki, Hiroaki, MD, PhD</creator><creator>Shimano, Hiroshi, MD, PhD</creator><creator>Kawakami, Yasushi, MD, PhD</creator><creator>Aonuma, Kazutaka, MD, PhD, FJCC</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3794-899X</orcidid></search><sort><creationdate>20161001</creationdate><title>Myocardial dysfunction identified by three-dimensional speckle tracking echocardiography in type 2 diabetes patients relates to complications of microangiopathy</title><author>Enomoto, Mami, MD ; Ishizu, Tomoko, MD, PhD, FJCC ; Seo, Yoshihiro, MD, PhD, FJCC ; Kameda, Yuri, BSc ; Suzuki, Hiroaki, MD, PhD ; Shimano, Hiroshi, MD, PhD ; Kawakami, Yasushi, MD, PhD ; Aonuma, Kazutaka, MD, PhD, FJCC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-ca1af85a1597d0219791c5f321405e0051ad35846168b95125cd7487420c67c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiovascular</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Angiopathies - complications</topic><topic>Diabetic cardiomyopathy</topic><topic>Echocardiography, Three-Dimensional - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Contraction - physiology</topic><topic>Myocardial strain</topic><topic>Three-dimensional echocardiography</topic><topic>Vascular Stiffness - physiology</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Enomoto, Mami, MD</creatorcontrib><creatorcontrib>Ishizu, Tomoko, MD, PhD, FJCC</creatorcontrib><creatorcontrib>Seo, Yoshihiro, MD, PhD, FJCC</creatorcontrib><creatorcontrib>Kameda, Yuri, BSc</creatorcontrib><creatorcontrib>Suzuki, Hiroaki, MD, PhD</creatorcontrib><creatorcontrib>Shimano, Hiroshi, MD, PhD</creatorcontrib><creatorcontrib>Kawakami, Yasushi, MD, PhD</creatorcontrib><creatorcontrib>Aonuma, Kazutaka, MD, PhD, FJCC</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enomoto, Mami, MD</au><au>Ishizu, Tomoko, MD, PhD, FJCC</au><au>Seo, Yoshihiro, MD, PhD, FJCC</au><au>Kameda, Yuri, BSc</au><au>Suzuki, Hiroaki, MD, PhD</au><au>Shimano, Hiroshi, MD, PhD</au><au>Kawakami, Yasushi, MD, PhD</au><au>Aonuma, Kazutaka, MD, PhD, FJCC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial dysfunction identified by three-dimensional speckle tracking echocardiography in type 2 diabetes patients relates to complications of microangiopathy</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>68</volume><issue>4</issue><spage>282</spage><epage>287</epage><pages>282-287</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Abstract Background The clinical effect of diabetic microangiopathy on left ventricular (LV) function is still uncertain. The purpose of this study was to assess the relation between diabetic microvascular complications and comprehensive myocardial deformation measurements using three-dimensional (3D) speckle tracking echocardiography. Methods Seventy-seven asymptomatic patients with type 2 diabetes mellitus (DM) and 35 age-matched healthy control subjects underwent 3D echocardiography. Patients with coronary artery disease or LV ejection fraction <50% were excluded. Presence of proliferative retinopathy, microalbuminuria as nephropathy, and decreased coefficient of variation of R-R intervals (CVRR) <3% as cardiac autonomic neuropathy were defined as diabetic microvascular complications. Results LV ejection fraction, LV mass index, and global radial strain did not differ between control and DM patients. However, global longitudinal and circumferential strain and endocardial area change ratio were lower in patients with DM than in the controls (−12.0 ± 3.0% vs. −16.2 ± 1.9%, −27.7 ± 7.1% vs. 32.2 ± 5.7%, −37.6 ± 7.6% vs. 44.0 ± 6.2%, respectively, p < 0.001). In DM patients, longitudinal strain is related to CVRR ( R = 0.58, p < 0.001), retinopathy stage, and nephropathy stage. Conclusions Diabetic microangiopathy and its accumulated effects significantly related to subclinical LV dysfunction are characterized by impaired longitudinal shortening.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>27146366</pmid><doi>10.1016/j.jjcc.2016.03.007</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3794-899X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiovascular Case-Control Studies Diabetes Mellitus, Type 2 - complications Diabetic Angiopathies - complications Diabetic cardiomyopathy Echocardiography, Three-Dimensional - methods Female Humans Male Middle Aged Myocardial Contraction - physiology Myocardial strain Three-dimensional echocardiography Vascular Stiffness - physiology Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology |
| title | Myocardial dysfunction identified by three-dimensional speckle tracking echocardiography in type 2 diabetes patients relates to complications of microangiopathy |
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