Metabolomic Approach for Discrimination of Four- and Six-Year-Old Red Ginseng (Panax ginseng) Using UPLC-QToF-MS
Panax ginseng C.A. MEYER is one of the most popular medicinal herbs in Asia and the chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discrimination of four- and six-year-old red ginseng using ultra-performan...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2016/09/01, Vol.64(9), pp.1298-1303 |
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| creator | Shin, Jung-Sub Park, Hee-Won In, Gyo Seo, Hyun Kyu Won, Tae Hyung Jang, Kyoung Hwa Cho, Byung-Goo Han, Chang Kyun Shin, Jongheon |
| description | Panax ginseng C.A. MEYER is one of the most popular medicinal herbs in Asia and the chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discrimination of four- and six-year-old red ginseng using ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component analysis (PCA) showed clear discrimination between extracts of red ginseng of different ages and suggest totally six discrimination markers (two for four-year-old and four for six-year-old red ginseng). Among these, one marker was isolated and the structure determined by NMR spectroscopic analysis was 13-cis-docosenamide (marker 6-1) from six-year-old red ginseng. This is the first report of a metabolomic study regarding the age differentiation of red ginseng using UPLC-QToF-MS and determination of the structure of the marker. These results will contribute to the quality control and standardization as well as provide a scientific basis for pharmacological research on red ginseng. |
| doi_str_mv | 10.1248/cpb.c16-00240 |
| format | Article |
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MEYER is one of the most popular medicinal herbs in Asia and the chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discrimination of four- and six-year-old red ginseng using ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component analysis (PCA) showed clear discrimination between extracts of red ginseng of different ages and suggest totally six discrimination markers (two for four-year-old and four for six-year-old red ginseng). Among these, one marker was isolated and the structure determined by NMR spectroscopic analysis was 13-cis-docosenamide (marker 6-1) from six-year-old red ginseng. This is the first report of a metabolomic study regarding the age differentiation of red ginseng using UPLC-QToF-MS and determination of the structure of the marker. These results will contribute to the quality control and standardization as well as provide a scientific basis for pharmacological research on red ginseng.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.c16-00240</identifier><identifier>PMID: 27383266</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>13-cis-docosenamide ; Chromatography, High Pressure Liquid ; Drying ; Ginseng ; Herbal medicine ; Liquid chromatography ; Mass Spectrometry ; Mass spectroscopy ; Medicinal herbs ; Medicinal plants ; Metabolomics ; multivariate analysis ; Multivariate statistical analysis ; NMR ; Nuclear magnetic resonance ; Organic chemistry ; Panax - chemistry ; Panax - metabolism ; Panax ginseng ; Pharmacology ; Principal components analysis ; Quality control ; red ginseng ; Republic of Korea ; Standardization ; Statistical analysis ; Steaming ; Time Factors ; ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS)</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2016/09/01, Vol.64(9), pp.1298-1303</ispartof><rights>2016 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-832c746f270f3597ce12323b25fefe098995ec42beceab295a2a5be7dc375f383</citedby><cites>FETCH-LOGICAL-c702t-832c746f270f3597ce12323b25fefe098995ec42beceab295a2a5be7dc375f383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27383266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Jung-Sub</creatorcontrib><creatorcontrib>Park, Hee-Won</creatorcontrib><creatorcontrib>In, Gyo</creatorcontrib><creatorcontrib>Seo, Hyun Kyu</creatorcontrib><creatorcontrib>Won, Tae Hyung</creatorcontrib><creatorcontrib>Jang, Kyoung Hwa</creatorcontrib><creatorcontrib>Cho, Byung-Goo</creatorcontrib><creatorcontrib>Han, Chang Kyun</creatorcontrib><creatorcontrib>Shin, Jongheon</creatorcontrib><creatorcontrib>aKorea Ginseng Research Institute</creatorcontrib><creatorcontrib>College of Pharmacy</creatorcontrib><creatorcontrib>Korea Ginseng Corporation</creatorcontrib><creatorcontrib>Seoul National University</creatorcontrib><creatorcontrib>bNatural Products Research Institute</creatorcontrib><title>Metabolomic Approach for Discrimination of Four- and Six-Year-Old Red Ginseng (Panax ginseng) Using UPLC-QToF-MS</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Panax ginseng C.A. MEYER is one of the most popular medicinal herbs in Asia and the chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discrimination of four- and six-year-old red ginseng using ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component analysis (PCA) showed clear discrimination between extracts of red ginseng of different ages and suggest totally six discrimination markers (two for four-year-old and four for six-year-old red ginseng). Among these, one marker was isolated and the structure determined by NMR spectroscopic analysis was 13-cis-docosenamide (marker 6-1) from six-year-old red ginseng. This is the first report of a metabolomic study regarding the age differentiation of red ginseng using UPLC-QToF-MS and determination of the structure of the marker. These results will contribute to the quality control and standardization as well as provide a scientific basis for pharmacological research on red ginseng.</description><subject>13-cis-docosenamide</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drying</subject><subject>Ginseng</subject><subject>Herbal medicine</subject><subject>Liquid chromatography</subject><subject>Mass Spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicinal herbs</subject><subject>Medicinal plants</subject><subject>Metabolomics</subject><subject>multivariate analysis</subject><subject>Multivariate statistical analysis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic chemistry</subject><subject>Panax - chemistry</subject><subject>Panax - metabolism</subject><subject>Panax ginseng</subject><subject>Pharmacology</subject><subject>Principal components analysis</subject><subject>Quality control</subject><subject>red ginseng</subject><subject>Republic of Korea</subject><subject>Standardization</subject><subject>Statistical analysis</subject><subject>Steaming</subject><subject>Time Factors</subject><subject>ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS)</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdFv0zAQxiMEYmXwyCuyxMt48HDsxI4fp0ILUqcNtj7wZDnOpXWV2iFOpfHfc2tGJ_FyJ_t--u67uyx7n7PLnBfVZ9fXly6XlDFesBfZLBeFoiXn4mU2Y4xpyoUUZ9mblHaIlEyJ19kZV6ISXMpZ1l_DaOvYxb135Krvh2jdlrRxIF98coPf-2BHHwOJLVnEw0CJDQ258w_0F9iB3nQN-QkNWfqQIGzIxa0N9oFspucnsk4ef9e3qzn9cR8X9PrubfaqtV2Cd0_5PFsvvt7Pv9HVzfL7_GpFnWJ8pGjPqUK2XLFWlFo5yLngouZlCy0wXWldgit4DQ5szXVpuS1rUI0TqmxxuvPsYtLFkX4fII1mjwNB19kA8ZBMXuVSiqosOaIf_0N3OGlAdwb3yIs811IgRSfKDTGlAVrT43rs8MfkzDyewuApDJ7CHE-B_Icn1UO9h-ZE_9s9AssJwKp3touh8wGee7uk3Bb23nB2FJUF05gqbKYxCCa44hJXgUrzSWmXRruBUys7jN51cDQmC6Mfw8ngc3VrBwNB_AUAR7CJ</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Shin, Jung-Sub</creator><creator>Park, Hee-Won</creator><creator>In, Gyo</creator><creator>Seo, Hyun Kyu</creator><creator>Won, Tae Hyung</creator><creator>Jang, Kyoung Hwa</creator><creator>Cho, Byung-Goo</creator><creator>Han, Chang Kyun</creator><creator>Shin, Jongheon</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Metabolomic Approach for Discrimination of Four- and Six-Year-Old Red Ginseng (Panax ginseng) Using UPLC-QToF-MS</title><author>Shin, Jung-Sub ; Park, Hee-Won ; In, Gyo ; Seo, Hyun Kyu ; Won, Tae Hyung ; Jang, Kyoung Hwa ; Cho, Byung-Goo ; Han, Chang Kyun ; Shin, Jongheon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-832c746f270f3597ce12323b25fefe098995ec42beceab295a2a5be7dc375f383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>13-cis-docosenamide</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drying</topic><topic>Ginseng</topic><topic>Herbal medicine</topic><topic>Liquid chromatography</topic><topic>Mass Spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medicinal herbs</topic><topic>Medicinal plants</topic><topic>Metabolomics</topic><topic>multivariate analysis</topic><topic>Multivariate statistical analysis</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic chemistry</topic><topic>Panax - chemistry</topic><topic>Panax - metabolism</topic><topic>Panax ginseng</topic><topic>Pharmacology</topic><topic>Principal components analysis</topic><topic>Quality control</topic><topic>red ginseng</topic><topic>Republic of Korea</topic><topic>Standardization</topic><topic>Statistical analysis</topic><topic>Steaming</topic><topic>Time Factors</topic><topic>ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Jung-Sub</creatorcontrib><creatorcontrib>Park, Hee-Won</creatorcontrib><creatorcontrib>In, Gyo</creatorcontrib><creatorcontrib>Seo, Hyun Kyu</creatorcontrib><creatorcontrib>Won, Tae Hyung</creatorcontrib><creatorcontrib>Jang, Kyoung Hwa</creatorcontrib><creatorcontrib>Cho, Byung-Goo</creatorcontrib><creatorcontrib>Han, Chang Kyun</creatorcontrib><creatorcontrib>Shin, Jongheon</creatorcontrib><creatorcontrib>aKorea Ginseng Research Institute</creatorcontrib><creatorcontrib>College of Pharmacy</creatorcontrib><creatorcontrib>Korea Ginseng Corporation</creatorcontrib><creatorcontrib>Seoul National University</creatorcontrib><creatorcontrib>bNatural Products Research Institute</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Jung-Sub</au><au>Park, Hee-Won</au><au>In, Gyo</au><au>Seo, Hyun Kyu</au><au>Won, Tae Hyung</au><au>Jang, Kyoung Hwa</au><au>Cho, Byung-Goo</au><au>Han, Chang Kyun</au><au>Shin, Jongheon</au><aucorp>aKorea Ginseng Research Institute</aucorp><aucorp>College of Pharmacy</aucorp><aucorp>Korea Ginseng Corporation</aucorp><aucorp>Seoul National University</aucorp><aucorp>bNatural Products Research Institute</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolomic Approach for Discrimination of Four- and Six-Year-Old Red Ginseng (Panax ginseng) Using UPLC-QToF-MS</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>64</volume><issue>9</issue><spage>1298</spage><epage>1303</epage><pages>1298-1303</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Panax ginseng C.A. MEYER is one of the most popular medicinal herbs in Asia and the chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discrimination of four- and six-year-old red ginseng using ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component analysis (PCA) showed clear discrimination between extracts of red ginseng of different ages and suggest totally six discrimination markers (two for four-year-old and four for six-year-old red ginseng). Among these, one marker was isolated and the structure determined by NMR spectroscopic analysis was 13-cis-docosenamide (marker 6-1) from six-year-old red ginseng. This is the first report of a metabolomic study regarding the age differentiation of red ginseng using UPLC-QToF-MS and determination of the structure of the marker. These results will contribute to the quality control and standardization as well as provide a scientific basis for pharmacological research on red ginseng.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>27383266</pmid><doi>10.1248/cpb.c16-00240</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 13-cis-docosenamide Chromatography, High Pressure Liquid Drying Ginseng Herbal medicine Liquid chromatography Mass Spectrometry Mass spectroscopy Medicinal herbs Medicinal plants Metabolomics multivariate analysis Multivariate statistical analysis NMR Nuclear magnetic resonance Organic chemistry Panax - chemistry Panax - metabolism Panax ginseng Pharmacology Principal components analysis Quality control red ginseng Republic of Korea Standardization Statistical analysis Steaming Time Factors ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS) |
| title | Metabolomic Approach for Discrimination of Four- and Six-Year-Old Red Ginseng (Panax ginseng) Using UPLC-QToF-MS |
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