Evaluation of a Silicone Membrane as an Alternative to Human Skin for Determining Skin Permeation Parameters of Chemical Compounds

We evaluated the effectiveness of a silicone membrane as an alternative to human skin using the skin permeation parameters of chemical compounds. An in vitro permeation study using 15 model compounds was conducted, and permeation parameters comprising permeability coefficient (P), diffusion paramete...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2016/09/01, Vol.64(9), pp.1338-1346
Hauptverfasser:	Uchida, Takashi, Yakumaru, Masafumi, Nishioka, Keisuke, Higashi, Yoshihiro, Sano, Tomohiko, Todo, Hiroaki, Sugibayashi, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative membrane Antipyrine Caffeine Chemical compounds Chromatography, High Pressure Liquid Cosmetics industry Flurbiprofen Humans Lipophilic Lipophilicity Mathematical models membrane permeation Models, Biological Organic chemistry Parameters Penetration Permeability Permeability coefficient Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry silicone membrane Silicones Silicones - chemistry Skin Skin - chemistry Skin Absorption Solubility
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