Design and Syntheses of Novel Fluoroporphyrin–Anthraquinone Complexes as Antitumor Agents

A novel fluoroporphyrin–anthraquinone hybrid with dipeptide link and its metal complexes were synthesized and evaluated for anti-proliferation activity in human cancer cell line HeLa. The preliminary results demonstrated that all the compounds showed moderate to excellent antitumor activities. Among...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2016/09/01, Vol.64(9), pp.1310-1314
Hauptverfasser:	Yang, Gu-Liang, Zhao, Sheng-Fang, Chen, Nian-You, Li, Shiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinone Anthraquinones - chemical synthesis Anthraquinones - chemistry Anthraquinones - pharmacology Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology antitumor activity Antitumor agents Cell Proliferation - drug effects Coordination compounds Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Fluorination HeLa Cells Humans Metal complexes microwave synthesis Molecular Structure Porphyrins - chemical synthesis Porphyrins - chemistry Porphyrins - pharmacology porphyrin–anthraquinone spectral characterization Structure-Activity Relationship Zinc
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