Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo

Panax notoginseng saponins (PNS) extracted from a traditional Chinese herbal medicine, Panax notoginseng (Burkill) F.H. Chen (Araliaceae), which has been extensively used in treating coronary heart disease, ischemic cerebrovascular disease and hemorrhagic disorders in China over hundreds of years. T...

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Veröffentlicht in:	Journal of ethnopharmacology 2016-08, Vol.190, p.301-312
Hauptverfasser:	Shi, Xiaowei, Yu, Wenjing, Yang, Tiantian, Liu, Wei, Zhao, Yizhou, Sun, Yikun, Chai, Limin, Gao, Yonghong, Dong, Bin, Zhu, Lingqun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - enzymology Brain - pathology Cell Hypoxia Cell Line, Tumor Cerebral infarction Disease Models, Animal Gene Expression Regulation, Enzymologic Glucose - deficiency Humans Infarction, Middle Cerebral Artery - enzymology Infarction, Middle Cerebral Artery - genetics Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - prevention & control Male NEP1-40 Neurons - drug effects Neurons - enzymology Neurons - pathology Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology NgR1 Nogo Receptor 1 - genetics Nogo Receptor 1 - metabolism Panax notoginseng - chemistry Panax notoginseng saponins Phytotherapy Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal Rats, Sprague-Dawley rho-Associated Kinases - genetics rho-Associated Kinases - metabolism RhoA rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism ROCK2 Saponins - isolation & purification Saponins - pharmacology Signal Transduction - drug effects Time Factors
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