Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats

Highlights • GL prevents oxidative stress after status epilepticus in the hippocampus and olfactory bulb. • Pretreatment with GL increases antioxidant enzyme activity in the hippocampus. • GL preserves enzyme activities in the olfactory bulb. • GL decreases inflammation in the hippocampus and olfact...

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Veröffentlicht in:Epilepsy research 2016-10, Vol.126, p.126-133
Hauptverfasser: González-Reyes, Susana, Santillán-Cigales, Juan Jair, Jiménez-Osorio, Angélica Saraí, Pedraza-Chaverri, José, Guevara-Guzmán, Rosalinda
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container_end_page 133
container_issue
container_start_page 126
container_title Epilepsy research
container_volume 126
creator González-Reyes, Susana
Santillán-Cigales, Juan Jair
Jiménez-Osorio, Angélica Saraí
Pedraza-Chaverri, José
Guevara-Guzmán, Rosalinda
description Highlights • GL prevents oxidative stress after status epilepticus in the hippocampus and olfactory bulb. • Pretreatment with GL increases antioxidant enzyme activity in the hippocampus. • GL preserves enzyme activities in the olfactory bulb. • GL decreases inflammation in the hippocampus and olfactory bulb after status epilepticus.
doi_str_mv 10.1016/j.eplepsyres.2016.07.007
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subjects Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antioxidants - chemistry
Antioxidants - pharmacology
Disease Models, Animal
Fluorometry
Glycyrrhizic Acid - chemistry
Glycyrrhizic Acid - pharmacology
Glycyrrhizin
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Hippocampus - pathology
Inflammation
Inflammation - drug therapy
Inflammation - metabolism
Inflammation - pathology
Lithium Compounds
Male
Neurology
Olfactory bulb
Olfactory Bulb - drug effects
Olfactory Bulb - metabolism
Olfactory Bulb - pathology
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Pilocarpine
Rats, Wistar
Status epilepticus
Status Epilepticus - drug therapy
Status Epilepticus - metabolism
Status Epilepticus - pathology
Stereoisomerism
title Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats
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