Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1

Ryanodine receptors (RyRs) are a class of giant ion channels with molecular mass over 2.2 mega-Daltons. These channels mediate calcium signaling in a variety of cells. Since more than 80% of the RyR protein is folded into the cytoplasmic assembly and the remaining residues form the transmembrane dom...

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Veröffentlicht in:	Cell research 2016-09, Vol.26 (9), p.977-994
Hauptverfasser:	Wei, Risheng, Wang, Xue, Zhang, Yan, Mukherjee, Saptarshi, Zhang, Lei, Chen, Qiang, Huang, Xinrui, Jing, Shan, Liu, Congcong, Li, Shuang, Wang, Guangyu, Xu, Yaofang, Zhu, Sujie, Williams, Alan J, Sun, Fei, Yin, Chang-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Animals Calcium - pharmacology EF Hand Motifs Ion Channel Gating - drug effects Models, Molecular Protein Domains Rabbits Ryanodine Receptor Calcium Release Channel - chemistry Ryanodine Receptor Calcium Release Channel - metabolism Ryanodine Receptor Calcium Release Channel - ultrastructure Structure-Activity Relationship
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