Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche

Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche

Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs a...

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Veröffentlicht in:Cell stem cell 2016-09, Vol.19 (3), p.284-286
Hauptverfasser: Di Scala, Marianna, Hidalgo, Andrés
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Sprache:eng
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Cell Differentiation
Hematopoietic Stem Cells
Humans
Regeneration
Stem Cell Niche
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container_title Cell stem cell
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creator Di Scala, Marianna
Hidalgo, Andrés
description Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs and proliferation of myeloid progenitors and dramatically enhances hematopoietic recovery after HSC transplantation. Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs and proliferation of myeloid progenitors and dramatically enhances hematopoietic recovery after HSC transplantation.
doi_str_mv 10.1016/j.stem.2016.08.017
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subjects Cell Differentiation
Hematopoietic Stem Cells
Humans
Regeneration
Stem Cell Niche
title Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche
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