Palladium-Catalyzed Norbornene-Mediated Tandem Amination/Cyanation Reaction: A Method for the Synthesis of ortho-Aminated Benzonitriles
A palladium-catalyzed, norbornene-mediated tandem amination/cyanation reaction via Catellani-type C–H functionalization was developed using N-benzoyloxyamines as the amination reagent and Zn(CN)2 as the terminating agent. This transformation, in which one C–N bond and one C–C bond are formed, provi...
Gespeichert in:
| Veröffentlicht in: | Organic letters 2016-09, Vol.18 (17), p.4166-4169 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | A palladium-catalyzed, norbornene-mediated tandem amination/cyanation reaction via Catellani-type C–H functionalization was developed using N-benzoyloxyamines as the amination reagent and Zn(CN)2 as the terminating agent. This transformation, in which one C–N bond and one C–C bond are formed, provides an efficient approach for the synthesis of ortho-aminated benzonitriles in one pot from easily accessible starting materials. |
|---|---|
| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/acs.orglett.6b02249 |