Apolipoprotein A-I Directly Interacts with Amyloid Precursor Protein and Inhibits Aβ Aggregation and Toxicity

Amyloid precursor protein (APP) is the source of the neurotoxic amyloid β (Aβ) peptide associated with Alzheimer's disease. Apolipoprotein A-I (apoA-I), a constituent of high-density lipoprotein complexes, was identified by a yeast two-hybrid system as a strong and specific binding partner of f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2001-03, Vol.40 (12), p.3553-3560
Hauptverfasser:	Koldamova, Radosveta P, Lefterov, Iliya M, Lefterova, Martina I, Lazo, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - toxicity Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Apolipoprotein A-I - metabolism Apolipoprotein A-I - pharmacology apolipoprotein AI Enzyme-Linked Immunosorbent Assay Extracellular Space - metabolism Humans Mutagenesis, Site-Directed Oxidation-Reduction PC12 Cells - drug effects PC12 Cells - metabolism Protein Structure, Tertiary - genetics Rats Sodium Dodecyl Sulfate Tetrazolium Salts - metabolism Thiazoles - metabolism Two-Hybrid System Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!