Remodeling of the Major Pig Xenoantigen by N-Acetylglucosaminyltransferase III in Transgenic Pig

We have been successful in generating several lines of transgenic mice and pigs that contain the human β-d-mannoside β-1,4-N-acetylglucosaminyltransferase III (GnT-III) gene. The overexpression of the GnT-III gene in mice and pigs reduced their antigenicity to human natural antibodies, especially th...

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Veröffentlicht in:	The Journal of biological chemistry 2001-10, Vol.276 (42), p.39310-39319
Hauptverfasser:	Miyagawa, Shuji, Murakami, Hiroshi, Takahagi, Yoichi, Nakai, Rie, Yamada, Mako, Murase, Ayako, Koyota, Souichi, Koma, Masaru, Matsunami, Katsuyoshi, Fukuta, Daisuke, Fujimura, Tatsuya, Shigehisa, Tamotsu, Okabe, Masaru, Nagashima, Hiroshi, Shirakura, Ryota, Taniguchi, Naoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Antigens, Heterophile - chemistry Antigens, Heterophile - genetics Cell Line Down-Regulation Female Flow Cytometry Glycosyltransferases - metabolism GnT-III gene Heart Transplantation Humans Immunohistochemistry L-Lactate Dehydrogenase - metabolism Macaca fascicularis Male Mice N-acetylglucosaminyltransferase III N-Acetylglucosaminyltransferases - metabolism Promoter Regions, Genetic Swine Tissue Distribution Transplantation, Heterologous xenoantigens
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