Exposure of preimplantation embryos to low-dose bisphenol A impairs testes development and suppresses histone acetylation of StAR promoter to reduce production of testosterone in mice

Previous studies have shown that bisphenol A (BPA) is a potential endocrine disruptor and testicular toxicant. The present study focused on exploring the impact of exposure to low dose of BPA on male reproductive development during the early embryo stage and the underlying mechanisms. BPA (20 μg/kg/...

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Veröffentlicht in:	Molecular and cellular endocrinology 2016-05, Vol.427, p.101-111
Hauptverfasser:	Hong, Juan, Chen, Fang, Wang, Xiaoli, Bai, Yinyang, Zhou, Rong, Li, Yingchun, Chen, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Benzhydryl Compounds - pharmacology Bisphenol A Blastocyst - drug effects Body Weight - drug effects Embryos Estrogens, Non-Steroidal - pharmacology Exposure Female Gonadal Steroid Hormones - metabolism Histone acetylation Histones Histones - metabolism Male Mice Mice, Inbred ICR Phenols - pharmacology Phosphoproteins - genetics Preimplantation embryo Promoter Regions, Genetic - drug effects Sertoli Cells - drug effects Sex Differentiation - drug effects Sex Differentiation - genetics StAR Stars Testes Testis - drug effects Testis - embryology Testis - metabolism Testosterone Testosterone - biosynthesis
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