Synthesis of novel imidazo[1,2-a]pyridine-4-hydroxy-2H-coumarins by Groebke–Blackburn–Bienaymé multicomponent reaction as potential NS5B inhibitors

A new series of imidazo[1,2-a]pyridine-coumarin hybrid has been developed by combining two biologically active pharmacophores coumarin and imidazo[1,2-a]pyridine following a Groebke–Blackburn–Bienaymé multicomponent reaction (MCR). Molecular docking studies of these novel compounds with nonstructura...

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Veröffentlicht in:	Tetrahedron 2016-03, Vol.72 (10), p.1293-1300
Hauptverfasser:	Manvar, Parth, Shaikh, Faraz, Kakadiya, Rajesh, Mehariya, Krunal, Khunt, Ranjan, Pandey, Bipin, Shah, Anamik
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxy-3-Formylcoumarin Binding Bonding Contact Docking Groebke–Blackburn–Bienaymé reaction Hepatitis C virus Hydrogen bonds Imidazo[1,2-a]pyridine Molecular docking Multicomponent reaction (MCR) NS5B inhibitors Pharmacology Proteins Tetrahedrons
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