Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage

This study aims to evaluate two proteins derived from the seeds of the plants Cajanus cajan (Leguminosae) and Caesalpinia gilliesii (Leguminosae) for their abilities to ameliorate the toxic effects of chronic doses of acetoaminphen (APAP) through the determination of certain biochemical parameters i...

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Veröffentlicht in:	Toxicology and industrial health 2016-05, Vol.32 (5), p.877-907
Hauptverfasser:	Rizk, Maha Z, Aly, Hanan F, Abo-Elmatty, Dina M, Desoky, MM, Ibrahim, N, Younis, Eman A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - toxicity Adenosine Triphosphatases - metabolism Alanine Transaminase - metabolism Alkaline Phosphatase - metabolism Animals Aspartate Aminotransferases - metabolism Bilirubin - metabolism Biochemistry Caesalpinia - chemistry Caesalpinia gilliesii Cajanus - chemistry Cajanus cajan Chemical and Drug Induced Liver Injury - drug therapy Congestion Damage Disease Models, Animal Dose-Response Relationship, Drug Enzymes Glutathione - metabolism Interleukin-6 - metabolism L-Lactate Dehydrogenase - metabolism Liver Liver - drug effects Liver - metabolism Male Markers Nitric Oxide - metabolism Peroxidase - metabolism Phosphates Plant Extracts - pharmacology Plant Proteins - pharmacology Proteins Rats Rats, Wistar Tumor Necrosis Factor-alpha - metabolism
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