The next generation of positron emission tomography radiopharmaceuticals labeled with non-conventional radionuclides

The next generation of positron emission tomography radiopharmaceuticals labeled with non-conventional radionuclides

The nuclear and chemical properties of ‘non-traditional’ positron emission tomography (PET) radionuclides, i.e.44Sc, 61,64Cu, 68Ga, 86Y, 89Zr, as well as their production routes are discussed. The bio-conjugation of these radionuclides with various vectors for target delivery to tumor cells using bi...

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Veröffentlicht in:Mendeleev communications 2016-03, Vol.26 (2), p.85-94
Hauptverfasser: Krasikova, Raisa N., Aliev, Ramiz A., Kalmykov, Stepan N.
Format: Artikel
Sprache:eng
Schlagworte:
Chelating
Chemical properties
Mathematical analysis
Positron emission
Tomography
Tumors
Vectors (mathematics)
Visualization
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Zusammenfassung:The nuclear and chemical properties of ‘non-traditional’ positron emission tomography (PET) radionuclides, i.e.44Sc, 61,64Cu, 68Ga, 86Y, 89Zr, as well as their production routes are discussed. The bio-conjugation of these radionuclides with various vectors for target delivery to tumor cells using bifunctional chelating agents is reviewed. The applications of various radiopharmaceuticals with ‘non-traditional’ PET radionuclides for molecular visualization of various tumors are summarized.
ISSN:0959-9436
DOI:10.1016/j.mencom.2016.03.001