In vitro neurotoxic hazard characterisation of dinitrophenolic herbicides

Dinitrophenolic compounds are powerful toxicants with a long history of use in agriculture and industry. While (high) human exposure levels are not uncommon, in particular for agricultural workers during the spraying season, the neurotoxic mechanism(s) that underlie the human health effects are larg...

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Veröffentlicht in:	Toxicology letters 2016-06, Vol.252, p.62-69
Hauptverfasser:	Heusinkveld, Harm J., van Vliet, Arie C., Nijssen, Peter C.G., Westerink, Remco H.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4-Dinitrophenol - analogs & derivatives 2,4-Dinitrophenol - toxicity Activation alpha-Synuclein - metabolism Animals Apoptosis - drug effects Calcium - metabolism Calcium Signaling - drug effects Caspase-mediated apoptosis Caspases - metabolism Cell Survival - drug effects Dinitrocresols - toxicity Dinitrophenolic herbicides Dose-Response Relationship, Drug Endoplasmic reticulum Enzyme Activation Exposure Fluorescence Herbicides Herbicides - toxicity Human In vitro neurotoxicology In vitro testing Labelling Mitochondria - drug effects Mitochondria - metabolism Neurons - drug effects Neurons - metabolism Neurons - pathology Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology Oxidative Stress - drug effects Pathways PC12 Cells Rats Reactive Oxygen Species - metabolism Risk Assessment Single cell Fura-2 Ca2+-imaging Time Factors Up-Regulation α-Synuclein
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