Si Photomultipliers for Bio-Sensing Applications
In this paper, silicon photomultipliers (SiPM) are proposed as optical detectors for bio sensing. Optical transduction is the most used detection mechanism in many biosensor applications, such as DNA microarray and real-time polymerase chain reaction. The performances of a 25 pixels device used for...
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| Veröffentlicht in: | IEEE journal of selected topics in quantum electronics 2016-05, Vol.22 (3), p.335-341 |
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| container_title | IEEE journal of selected topics in quantum electronics |
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| creator | Santangelo, Maria Francesca Sciuto, Emanuele Luigi Lombardo, Salvatore A. Busacca, Alessandro C. Petralia, Salvatore Conoci, Sabrina Libertino, Sebania |
| description | In this paper, silicon photomultipliers (SiPM) are proposed as optical detectors for bio sensing. Optical transduction is the most used detection mechanism in many biosensor applications, such as DNA microarray and real-time polymerase chain reaction. The performances of a 25 pixels device used for both applications are studied. The results confirm that the SiPM is more sensitive than the traditionally employed detectors. In fact, it is able to experimentally detect 1 nM and 100 fM of fluorophore concentrations in dried samples and solutions, respectively. We present and discuss in details the detector configuration and its characterization as fluorescence detector for bio sensing. |
| doi_str_mv | 10.1109/JSTQE.2015.2504979 |
| format | Article |
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We present and discuss in details the detector configuration and its characterization as fluorescence detector for bio sensing.</description><subject>Biomedical measurement</subject><subject>Biomedical optical imaging</subject><subject>Chemical compounds</subject><subject>Detection</subject><subject>Detectors</subject><subject>DNA</subject><subject>DNA microarray</subject><subject>Fluorescence</subject><subject>Multiplier phototubes</subject><subject>Optical biosensor system</subject><subject>Optical sensors</subject><subject>Photomultipliers</subject><subject>Probes</subject><subject>Quantum electronics</subject><subject>RT PCR</subject><subject>Silicon</subject><subject>Silicon Photomultipliers</subject><subject>Temperature measurement</subject><issn>1077-260X</issn><issn>1558-4542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNpdkE1LAzEQhhdRsFb_gF4WvHjZOvnabI5V6hcFlVbwFtJsoinbzZrsHvz3prZ48DQD87zDy5Nl5wgmCIG4flosX2cTDIhNMAMquDjIRoixqqCM4sO0A-cFLuH9ODuJcQ0AFa1glMHC5S-fvveboeld1zgTYm59yG-cLxamja79yKddOmjVO9_G0-zIqiaas_0cZ293s-XtQzF_vn-8nc4LTXDVF0ZX1FhikGbU1krTFV2ldlhDjbCyhPJSqdIKooRAqlTVyhqUCIHrWiBWk3F2tfvbBf81mNjLjYvaNI1qjR-iRBUqARDgMqGX_9C1H0Kb2knEq1JwYJwnCu8oHXyMwVjZBbdR4VsikFuJ8lei3EqUe4kpdLELOWPMX4ATSjgR5AeaRm0x</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Santangelo, Maria Francesca</creator><creator>Sciuto, Emanuele Luigi</creator><creator>Lombardo, Salvatore A.</creator><creator>Busacca, Alessandro C.</creator><creator>Petralia, Salvatore</creator><creator>Conoci, Sabrina</creator><creator>Libertino, Sebania</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. 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| source | IEEE Electronic Library (IEL) |
| subjects | Biomedical measurement Biomedical optical imaging Chemical compounds Detection Detectors DNA DNA microarray Fluorescence Multiplier phototubes Optical biosensor system Optical sensors Photomultipliers Probes Quantum electronics RT PCR Silicon Silicon Photomultipliers Temperature measurement |
| title | Si Photomultipliers for Bio-Sensing Applications |
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