Transketolase catalysed upgrading of l -arabinose: the one-step stereoselective synthesis of l -gluco-heptulose
Conversion of biomass using biocatalysis is likely to become a technology that contributes significantly to the future production of chemical building blocks, materials and transport fuels. Here the synthesis of a value-added chemical from l-arabinose, a major component of the carbohydrates in sugar...
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| Veröffentlicht in: | Green chemistry : an international journal and green chemistry resource : GC 2016-01, Vol.18 (10), p.3158-3165 |
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| container_title | Green chemistry : an international journal and green chemistry resource : GC |
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| creator | Subrizi, Fabiana Cardenas-Fernandez, Max Lye, Gary J Ward, John M Dalby, Paul A Sheppard, Tom D Hailes, Helen C |
| description | Conversion of biomass using biocatalysis is likely to become a technology that contributes significantly to the future production of chemical building blocks, materials and transport fuels. Here the synthesis of a value-added chemical from l-arabinose, a major component of the carbohydrates in sugar beet pulp (SBP), in a concise and sustainable manner has been investigated. Biocatalytic conversions using transketolase variants have been developed for the efficient, scalable synthesis of a rare naturally occurring ketoheptose, l-gluco-heptulose, from l-arabinose. New active E. coli TK mutants that readily accept l-arabinose were identified using a versatile colorimetric screening assay and the reaction was performed on a preparative scale. |
| doi_str_mv | 10.1039/c5gc02660a |
| format | Article |
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| identifier | ISSN: 1463-9262 |
| ispartof | Green chemistry : an international journal and green chemistry resource : GC, 2016-01, Vol.18 (10), p.3158-3165 |
| issn | 1463-9262 1463-9270 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Carbohydrates Colorimetry Conversion Screening Sustainability Synthesis Transport Upgrading |
| title | Transketolase catalysed upgrading of l -arabinose: the one-step stereoselective synthesis of l -gluco-heptulose |
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