A degradable polydopamine coating based on disulfide-exchange reaction
Although the programmed degradation of biocompatible films finds applications in various fields including biomedical and bionanotechnological areas, coating methods have generally been limited to be substrate-specific, not applicable to any kinds of substrates. In this paper, we report a dopamine de...
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| Veröffentlicht in: | Nanoscale 2015-12, Vol.7 (47), p.20149-20154 |
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| container_end_page | 20154 |
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| container_issue | 47 |
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| container_title | Nanoscale |
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| creator | Hong, Daewha Lee, Hojae Kim, Beom Jin Park, Taegyun Choi, Ji Yu Park, Matthew Lee, Juno Cho, Hyeoncheol Hong, Seok-Pyo Yang, Sung Ho Jung, Sun Ho Ko, Sung-Bo Choi, Insung S |
| description | Although the programmed degradation of biocompatible films finds applications in various fields including biomedical and bionanotechnological areas, coating methods have generally been limited to be substrate-specific, not applicable to any kinds of substrates. In this paper, we report a dopamine derivative, which allows for both universal coating of various substrates and stimuli-responsive film degradation, inspired by mussel-adhesive proteins. Two dopamine moieties are linked together by the disulfide bond, the cleavage of which enables the programmed film degradation. Mechanistic analysis of the degradable films indicates that the initial cleavage of the disulfide linkage causes rapid uptake of water molecules, hydrating the films, which leads to rapid degradation. Our substrate-independent coating of degradable films provides an advanced tool for drug delivery systems, tissue engineering, and anti-fouling strategies. |
| doi_str_mv | 10.1039/c5nr06460k |
| format | Article |
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In this paper, we report a dopamine derivative, which allows for both universal coating of various substrates and stimuli-responsive film degradation, inspired by mussel-adhesive proteins. Two dopamine moieties are linked together by the disulfide bond, the cleavage of which enables the programmed film degradation. Mechanistic analysis of the degradable films indicates that the initial cleavage of the disulfide linkage causes rapid uptake of water molecules, hydrating the films, which leads to rapid degradation. Our substrate-independent coating of degradable films provides an advanced tool for drug delivery systems, tissue engineering, and anti-fouling strategies.</description><identifier>ISSN: 2040-3364</identifier><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/c5nr06460k</identifier><identifier>PMID: 26572596</identifier><language>eng</language><publisher>England</publisher><subject>Adhesives - chemistry ; Animals ; Biocompatible Materials - chemistry ; Bivalvia ; Buffers ; Cleavage ; Coated Materials, Biocompatible - chemistry ; Coating ; Degradation ; Derivatives ; Disulfides ; Disulfides - chemistry ; Dopamine ; Dopamine - chemistry ; Doxorubicin - chemistry ; Drug Delivery Systems ; Glutathione - chemistry ; Indoles - chemistry ; Levodopa - chemistry ; Nanotechnology - methods ; Polymers - chemistry ; Proteins - chemistry ; Spectroscopy, Fourier Transform Infrared ; Strategy ; Substrates ; Surface Properties ; Tissue Engineering - methods ; Water - chemistry</subject><ispartof>Nanoscale, 2015-12, Vol.7 (47), p.20149-20154</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-b4befd2e412916890cbc941b4d70d9acdc0848124f607fe8614235365159975e3</citedby><cites>FETCH-LOGICAL-c357t-b4befd2e412916890cbc941b4d70d9acdc0848124f607fe8614235365159975e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26572596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Daewha</creatorcontrib><creatorcontrib>Lee, Hojae</creatorcontrib><creatorcontrib>Kim, Beom Jin</creatorcontrib><creatorcontrib>Park, Taegyun</creatorcontrib><creatorcontrib>Choi, Ji Yu</creatorcontrib><creatorcontrib>Park, Matthew</creatorcontrib><creatorcontrib>Lee, Juno</creatorcontrib><creatorcontrib>Cho, Hyeoncheol</creatorcontrib><creatorcontrib>Hong, Seok-Pyo</creatorcontrib><creatorcontrib>Yang, Sung Ho</creatorcontrib><creatorcontrib>Jung, Sun Ho</creatorcontrib><creatorcontrib>Ko, Sung-Bo</creatorcontrib><creatorcontrib>Choi, Insung S</creatorcontrib><title>A degradable polydopamine coating based on disulfide-exchange reaction</title><title>Nanoscale</title><addtitle>Nanoscale</addtitle><description>Although the programmed degradation of biocompatible films finds applications in various fields including biomedical and bionanotechnological areas, coating methods have generally been limited to be substrate-specific, not applicable to any kinds of substrates. 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Our substrate-independent coating of degradable films provides an advanced tool for drug delivery systems, tissue engineering, and anti-fouling strategies.</description><subject>Adhesives - chemistry</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Bivalvia</subject><subject>Buffers</subject><subject>Cleavage</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coating</subject><subject>Degradation</subject><subject>Derivatives</subject><subject>Disulfides</subject><subject>Disulfides - chemistry</subject><subject>Dopamine</subject><subject>Dopamine - chemistry</subject><subject>Doxorubicin - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Glutathione - chemistry</subject><subject>Indoles - chemistry</subject><subject>Levodopa - chemistry</subject><subject>Nanotechnology - methods</subject><subject>Polymers - chemistry</subject><subject>Proteins - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Strategy</subject><subject>Substrates</subject><subject>Surface Properties</subject><subject>Tissue Engineering - methods</subject><subject>Water - chemistry</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E9LwzAYx_EgipvTiy9AehShmv9pjmM4FYeC6LmkydNZbZuatODevZubu3p6nsOH3-GL0DnB1wQzfWNFG7DkEn8eoDHFHKeMKXq4_yUfoZMYPzCWmkl2jEZUCkWFlmM0nyYOlsE4U9SQdL5eOd-Zpmohsd70VbtMChPBJb5NXBWHuqwcpPBt3027hCSAsX3l21N0VJo6wtnuTtDb_PZ1dp8unu8eZtNFaplQfVrwAkpHgROqicw0toXVnBTcKey0sc7ijGeE8lJiVUImCadMMCmI0FoJYBN0ud3tgv8aIPZ5U0ULdW1a8EPMSbaRlKjsf6qY4hkmgq7p1Zba4GMMUOZdqBoTVjnB-SZxPhNPL7-JH9f4Yrc7FA24Pf1ryn4A28J1Lw</recordid><startdate>20151221</startdate><enddate>20151221</enddate><creator>Hong, Daewha</creator><creator>Lee, Hojae</creator><creator>Kim, Beom Jin</creator><creator>Park, Taegyun</creator><creator>Choi, Ji Yu</creator><creator>Park, Matthew</creator><creator>Lee, Juno</creator><creator>Cho, Hyeoncheol</creator><creator>Hong, Seok-Pyo</creator><creator>Yang, Sung Ho</creator><creator>Jung, Sun Ho</creator><creator>Ko, Sung-Bo</creator><creator>Choi, Insung S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20151221</creationdate><title>A degradable polydopamine coating based on disulfide-exchange reaction</title><author>Hong, Daewha ; Lee, Hojae ; Kim, Beom Jin ; Park, Taegyun ; Choi, Ji Yu ; Park, Matthew ; Lee, Juno ; Cho, Hyeoncheol ; Hong, Seok-Pyo ; Yang, Sung Ho ; Jung, Sun Ho ; Ko, Sung-Bo ; Choi, Insung S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-b4befd2e412916890cbc941b4d70d9acdc0848124f607fe8614235365159975e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adhesives - chemistry</topic><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Bivalvia</topic><topic>Buffers</topic><topic>Cleavage</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Coating</topic><topic>Degradation</topic><topic>Derivatives</topic><topic>Disulfides</topic><topic>Disulfides - chemistry</topic><topic>Dopamine</topic><topic>Dopamine - chemistry</topic><topic>Doxorubicin - chemistry</topic><topic>Drug Delivery Systems</topic><topic>Glutathione - chemistry</topic><topic>Indoles - chemistry</topic><topic>Levodopa - chemistry</topic><topic>Nanotechnology - methods</topic><topic>Polymers - chemistry</topic><topic>Proteins - chemistry</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Strategy</topic><topic>Substrates</topic><topic>Surface Properties</topic><topic>Tissue Engineering - methods</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Daewha</creatorcontrib><creatorcontrib>Lee, Hojae</creatorcontrib><creatorcontrib>Kim, Beom Jin</creatorcontrib><creatorcontrib>Park, Taegyun</creatorcontrib><creatorcontrib>Choi, Ji Yu</creatorcontrib><creatorcontrib>Park, Matthew</creatorcontrib><creatorcontrib>Lee, Juno</creatorcontrib><creatorcontrib>Cho, Hyeoncheol</creatorcontrib><creatorcontrib>Hong, Seok-Pyo</creatorcontrib><creatorcontrib>Yang, Sung Ho</creatorcontrib><creatorcontrib>Jung, Sun Ho</creatorcontrib><creatorcontrib>Ko, Sung-Bo</creatorcontrib><creatorcontrib>Choi, Insung S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Daewha</au><au>Lee, Hojae</au><au>Kim, Beom Jin</au><au>Park, Taegyun</au><au>Choi, Ji Yu</au><au>Park, Matthew</au><au>Lee, Juno</au><au>Cho, Hyeoncheol</au><au>Hong, Seok-Pyo</au><au>Yang, Sung Ho</au><au>Jung, Sun Ho</au><au>Ko, Sung-Bo</au><au>Choi, Insung S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A degradable polydopamine coating based on disulfide-exchange reaction</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2015-12-21</date><risdate>2015</risdate><volume>7</volume><issue>47</issue><spage>20149</spage><epage>20154</epage><pages>20149-20154</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Although the programmed degradation of biocompatible films finds applications in various fields including biomedical and bionanotechnological areas, coating methods have generally been limited to be substrate-specific, not applicable to any kinds of substrates. 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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Adhesives - chemistry Animals Biocompatible Materials - chemistry Bivalvia Buffers Cleavage Coated Materials, Biocompatible - chemistry Coating Degradation Derivatives Disulfides Disulfides - chemistry Dopamine Dopamine - chemistry Doxorubicin - chemistry Drug Delivery Systems Glutathione - chemistry Indoles - chemistry Levodopa - chemistry Nanotechnology - methods Polymers - chemistry Proteins - chemistry Spectroscopy, Fourier Transform Infrared Strategy Substrates Surface Properties Tissue Engineering - methods Water - chemistry |
| title | A degradable polydopamine coating based on disulfide-exchange reaction |
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