Acid-mediated topological control in a functionalized foldamer

Acid-mediated topological control in a functionalized foldamer

Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helica...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (39), p.6521-6524
Hauptverfasser: Knipe, Peter C, Thompson, Sam, Hamilton, Andrew D
Format: Artikel
Sprache:eng
Schlagworte:
Helical
Molecular structure
Pyridines
Synthesis
Topology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies. Protonation mediates the transition between linear and helical foldamer topologies giving rise to a dynamic, functionalized molecular surface.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc01496h