Depletion of cathepsin D by transglutaminase 2 through protein cross-linking promotes cell survival

Transglutaminase 2 (TGase 2) promotes nuclear factor-κB (NF-κB) activity through depletion of the inhibitory subunit of NF-κB (I-κBα) via protein cross-linking, leading to resolution of inflammation. Increased expression of TGase 2 contributes to inflammatory disease pathogenesis via constitutive NF...

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Veröffentlicht in:	Amino acids 2013-01, Vol.44 (1), p.73-80
Hauptverfasser:	Kim, Se-Jin, Kim, Kyung-Hee, Ahn, Eu-Ree, Yoo, Byong Chul, Kim, Soo-Youl
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analytical Chemistry Animals Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - chemistry bcl-2-Associated X Protein - isolation & purification Biochemical Engineering Biochemistry Biomedical and Life Sciences Caspase 3 - metabolism Cathepsin D Cathepsin D - chemistry Cathepsin D - isolation & purification Cathepsin D - metabolism Cell Survival Cells, Cultured Chromatography, Affinity Crosslinking Cycloheximide - pharmacology Depletion Enzymes, Immobilized Gene Knockout Techniques GTP-Binding Proteins - chemistry GTP-Binding Proteins - metabolism Guinea Pigs Humans Life Sciences Mathematical models Mice Neurobiology Original Article Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - metabolism Protein Binding Protein Interaction Mapping Protein Multimerization Proteins Proteomics Tandem Mass Spectrometry Transglutaminases - chemistry Transglutaminases - metabolism Tumor Necrosis Factor-alpha - pharmacology
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